Results 31 to 40 of about 26,568 (204)

Dual Vulnerability of Tau to Calpains and Caspase-3 Proteolysis Under Neurotoxic and Neurodegenerative Conditions

ASN Neuro, 2010
Axonally specific microtubule-associated protein tau is an important component of neurofibrillary tangles found in AD (Alzheimer's disease) and other tauopathy diseases such as CTE (chronic traumatic encephalopathy).
Ming Cheng Liu, Firas Kobeissy, Wenrong Zheng, Zhiqun Zhang, Ronald L Hayes, Kevin K.W Wang   +5 more
doaj   +1 more source

Calpain inhibition ameliorates scald burn-induced acute lung injury in rats

Burns & Trauma, 2018
Background The molecular pattern of severe burn-induced acute lung injury, characterized by cell structure damage and leukocyte infiltration, remains unknown.
Peng-Ran Du, Hong-Ting Lu, Xi-Xiang Lin, Li-Feng Wang, Yan-Xia Wang, Xiao-Ming Gu, Xiao-Zhi Bai, Ke Tao, Jing-Jun Zhou   +8 more
doaj   +1 more source

Calpain inhibitor PD150606 attenuates glutamate induced spiral ganglion neuron apoptosis through apoptosis inducing factor pathway in vitro. [PDF]

PLoS ONE, 2015
This research aimed to investigate whether glutamate induced spiral ganglion neurons (SGNs) apoptosis through apoptosis inducing factor (AIF) pathway.
Zhong-Jia Ding, Xin Chen, Xiao-Xu Tang, Xi Wang, Yong-Li Song, Xiao-Dong Chen, Wen-Juan Mi, Jian Wang, Ying Lin, Fu-Quan Chen, Jian-Hua Qiu   +10 more
doaj   +1 more source

Acetylcholine Attenuated TNF-α-Induced Apoptosis in H9c2 Cells: Role of Calpain and the p38-MAPK Pathway

Cellular Physiology and Biochemistry, 2015
Background: Previous studies have shown that inflammation is associated with excessive activation of calpains. Acetylcholine (ACh) has been reported to inhibit pro-inflammatory cytokine release and protect against cardiomyocyte injury.
Ming Zhao, Yang Yang, Xueyuan Bi, Xiaojiang Yu, Hanghuan Jia, Huanle Fang, Weijin Zang   +6 more
doaj   +1 more source

A calpain inhibitor protects against fractalkine production in lipopolysaccharide-treated endothelial cells

Kidney Research and Clinical Practice, 2017
Background: Fractalkine (CX3CL1) is a chemokine with a unique CX3C motif and is produced by endothelial cells stimulated with lipopolysaccharide (LPS), tumor necrosis factor (TNF)-α, interleukin (IL)-1, and interferon-γ.
Jaewoong Jang, Yoosik Yoon, Dong-Jin Oh
doaj   +1 more source

Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens

BMC Neuroscience, 2006
Background Glutamate, a major excitatory amino acid neurotransmitter, causes apoptotic neuronal cell death at high concentrations. Our previous studies have shown that depending on the neuronal cell type, glutamate-induced apoptotic cell death was ...
Bhavnani Bhagu R, Zhang YueMei
doaj   +1 more source

Similar to spironolactone, oxymatrine is protective in aldosterone-induced cardiomyocyte injury via inhibition of calpain and apoptosis-inducing factor signaling.

PLoS ONE, 2014
Accumulating evidence indicates that oxymatrine (OMT) possesses variously pharmacological properties, especially on the cardiovascular system. We previously demonstrated that activated calpain/apoptosis-inducing factor (AIF)-mediated pathway was the key ...
Ting-Ting Xiao, Yuan-Yuan Wang, Yan Zhang, Cong-Hui Bai, Xiang-Chun Shen   +4 more
doaj   +1 more source

Expression and localization of calpain 3 in the submandibular gland of mice

Archives of Oral Biology, 2016
Calpains comprise a family of intracellular Ca2+-dependent cysteine proteases and are considered to play roles in various physiological phenomena with limited proteolytic activities against specific substrates. We herein revealed the expression and localization of calpain 3, the muscle-type calpain, in the submandibular gland (SMG) of mice.The ...
Tewarat Kumchantuek, Hiroki Nakata, Natthiya Sakulsak, Miyuki Yamamoto, Shoichi Iseki   +4 more
openaire   +2 more sources

Clinical severity of β-thalassaemia/Hb E disease is associated with differential activities of the calpain-calpastatin proteolytic system. [PDF]

PLoS ONE, 2012
Earlier observations in the literature suggest that proteolytic degradation of excess unmatched α-globin chains reduces their accumulation and precipitation in β-thalassaemia erythroid precursor cells and have linked this proteolytic degradation to the ...
Suriyan Sukati, Saovaros Svasti, Roberto Stifanese, Monica Averna, Nantika Panutdaporn, Tipparat Penglong, Edon Melloni, Suthat Fucharoen, Gerd Katzenmeier   +8 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source