Results 41 to 50 of about 28,592 (236)
Human μ-calpain: Simple isolation from erythrocytes and characterization of autolysis fragments [PDF]
, 2001 Heterodimeric μ-calpain, consisting of the large (80 kDa) and the small (30 kDa) subunit, was isolated and purified from human erythrocytes by a highly reproducible four-step purification procedure.
Mentele, Reinhard +7 more
core +1 more source
Cellular Physiology and Biochemistry, 2015 Aims: The aim of this study was to determine whether calpain is involved in Cl- -induced myocardial ischemia/reperfusion (I/R) injury. Methods: Isolated rat hearts were subjected to either 45 min of global no-flow ischemia followed by reperfusion or ...
Jian-Ying Zhang +7 more
doaj +1 more source
Arthritis Research & Therapy, 2022 Background Calpains are a family of calcium-dependent thiol proteases that participate in a wide variety of biological activities. In our recent study, calpain is increased in the sera of scleroderma or systemic sclerosis (SSc).
Li Zhang +8 more
doaj +1 more source
Frontiers in Neurology, 2021 We present a patient who had two allogeneic bone marrow transplantations for acute lymphocytic leukemia. She developed slowly progressive limb-girdle weakness in the context of other symptoms of graft-vs.-host disease (GVHD).
Kristina Martens +6 more
doaj +1 more source
Reduction of myocardial infarction by postischemic administration of the calpain inhibitor A-705253 in comparison to the Na(+)/H(+) exchange inhibitor Cariporide (R) in isolated perfused rabbit hearts [PDF]
, 2008 The calpain inhibitor A-705253 and the Na(+)/H(+) exchange inhibitor Cariporide (R) were studied in isolated perfused rabbit hearts subjected to 60 min occlusion of the ramus interventricularis of the left coronary artery (below the origin of the first ...
Speth, Maria +7 more
core +1 more source
Effects of Yam and Diosgenin on Calpain Systems in Skeletal Muscle of Ovariectomized Rats
Taiwanese Journal of Obstetrics & Gynecology, 2008 Objective: Yam or diosgenin (extracted from the root of wild yam) is traditionally used for hormone replacement in menopausal women. Calpains are crucially related to the degradation of myofibrillar proteins in skeletal muscle.
Kung-Hao Hsu +4 more
doaj +1 more source
Autolytic activation of calpain 3 proteinase is facilitated by calmodulin protein. [PDF]
J Biol Chem, 2015 Calpains are broadly distributed, calcium-dependent enzymes that induce limited proteolysis in a wide range of substrates. Mutations in the gene encoding the muscle-specific family member calpain 3 (CAPN3) underlie limb-girdle muscular dystrophy 2A.
Ermolova N, Kramerova I, Spencer MJ.
europepmc +6 more sources
ASN Neuro, 2010 Axonally specific microtubule-associated protein tau is an important component of neurofibrillary tangles found in AD (Alzheimer's disease) and other tauopathy diseases such as CTE (chronic traumatic encephalopathy).
Ming Cheng Liu +5 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2015 Background: Previous studies have shown that inflammation is associated with excessive activation of calpains. Acetylcholine (ACh) has been reported to inhibit pro-inflammatory cytokine release and protect against cardiomyocyte injury.
Ming Zhao +6 more
doaj +1 more source
Calpain inhibition ameliorates scald burn-induced acute lung injury in rats
Burns & Trauma, 2018 Background The molecular pattern of severe burn-induced acute lung injury, characterized by cell structure damage and leukocyte infiltration, remains unknown.
Peng-Ran Du +8 more
doaj +1 more source