Results 51 to 60 of about 28,592 (236)

Calpain inhibitor PD150606 attenuates glutamate induced spiral ganglion neuron apoptosis through apoptosis inducing factor pathway in vitro. [PDF]

PLoS ONE, 2015
This research aimed to investigate whether glutamate induced spiral ganglion neurons (SGNs) apoptosis through apoptosis inducing factor (AIF) pathway.
Zhong-Jia Ding, Xin Chen, Xiao-Xu Tang, Xi Wang, Yong-Li Song, Xiao-Dong Chen, Wen-Juan Mi, Jian Wang, Ying Lin, Fu-Quan Chen, Jian-Hua Qiu   +10 more
doaj   +1 more source

A calpain inhibitor protects against fractalkine production in lipopolysaccharide-treated endothelial cells

Kidney Research and Clinical Practice, 2017
Background: Fractalkine (CX3CL1) is a chemokine with a unique CX3C motif and is produced by endothelial cells stimulated with lipopolysaccharide (LPS), tumor necrosis factor (TNF)-α, interleukin (IL)-1, and interferon-γ.
Jaewoong Jang, Yoosik Yoon, Dong-Jin Oh
doaj   +1 more source

Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens

BMC Neuroscience, 2006
Background Glutamate, a major excitatory amino acid neurotransmitter, causes apoptotic neuronal cell death at high concentrations. Our previous studies have shown that depending on the neuronal cell type, glutamate-induced apoptotic cell death was ...
Bhavnani Bhagu R, Zhang YueMei
doaj   +1 more source

Expression and localization of calpain 3 in the submandibular gland of mice

Archives of Oral Biology, 2016
Calpains comprise a family of intracellular Ca2+-dependent cysteine proteases and are considered to play roles in various physiological phenomena with limited proteolytic activities against specific substrates. We herein revealed the expression and localization of calpain 3, the muscle-type calpain, in the submandibular gland (SMG) of mice.The ...
Tewarat Kumchantuek, Hiroki Nakata, Natthiya Sakulsak, Miyuki Yamamoto, Shoichi Iseki   +4 more
openaire   +2 more sources

Similar to spironolactone, oxymatrine is protective in aldosterone-induced cardiomyocyte injury via inhibition of calpain and apoptosis-inducing factor signaling.

PLoS ONE, 2014
Accumulating evidence indicates that oxymatrine (OMT) possesses variously pharmacological properties, especially on the cardiovascular system. We previously demonstrated that activated calpain/apoptosis-inducing factor (AIF)-mediated pathway was the key ...
Ting-Ting Xiao, Yuan-Yuan Wang, Yan Zhang, Cong-Hui Bai, Xiang-Chun Shen   +4 more
doaj   +1 more source

Clinical severity of β-thalassaemia/Hb E disease is associated with differential activities of the calpain-calpastatin proteolytic system. [PDF]

PLoS ONE, 2012
Earlier observations in the literature suggest that proteolytic degradation of excess unmatched α-globin chains reduces their accumulation and precipitation in β-thalassaemia erythroid precursor cells and have linked this proteolytic degradation to the ...
Suriyan Sukati, Saovaros Svasti, Roberto Stifanese, Monica Averna, Nantika Panutdaporn, Tipparat Penglong, Edon Melloni, Suthat Fucharoen, Gerd Katzenmeier   +8 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2

Scientific Reports, 2016
Cholinergic impairments and tau accumulation are hallmark pathologies in sporadic Alzheimer’s disease (AD), however, the intrinsic link between tau accumulation and cholinergic deficits is missing.
Yaling Yin, Yali Wang, Di Gao, Jinwang Ye, Xin Wang, Lin Fang, Dongqin Wu, Guilin Pi, Chengbiao Lu, Xin-Wen Zhou, Ying Yang, Jian-Zhi Wang   +11 more
doaj   +1 more source

Traumatic mechanical injury to the hippocampus in vitro causes regional caspase-3 and calpain activation that is influenced by NMDA receptor subunit composition

Neurobiology of Disease, 2006
Apoptotic or necrotic cell death in the hippocampus is a major factor underlying the cognitive impairments following traumatic brain injury. In this study, we examined if traumatic mechanical injury would produce regional activation of calpain and ...
Michael N. DeRidder, Melissa J. Simon, Robert Siman, Yves P. Auberson, Ramesh Raghupathi, David F. Meaney   +5 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source