Results 61 to 70 of about 28,592 (236)

CD28‐Targeted Enzyme‐Responsive Conformation‐Switching Peptide Self‐Assembly for Selective T‐Cell Acute Lymphoblastic Leukemia (T‐ALL) Therapy

Advanced Science, EarlyView.
We developed the enzyme‐responsive peptide SAp‐CD28 to selectively target CD28‐overexpressing T‐ALL cells. Following phosphatase‐mediated activation, SAp‐CD28 undergoes conformational switching and nanooligomerization, resulting in the disruption of CD28 downstream signaling.
Jun Li, Ziyu Jia, Dekun Li, Zhi‐Wen Hu, Yinghao Ding, Shengyi Zhang, Shengkun Tuo, Zhimou Yang, Huisheng Fu, Ling Wang, Man‐Di Wang   +10 more
wiley   +1 more source

Characterisation and expression of calpain family members in relation to nutritional status, diet composition and flesh texture in gilthead sea bream (Sparus aurata).

, 2013
Calpains are non-lysosomal calcium-activated neutral proteases involved in a wide range of cellular processes including muscle proteolysis linked to post-mortem flesh softening.
Encarnación Capilla (462852), Fontanillas, Ramon, Navarro Álvarez, Isabel, Salmerón Salvador, Cristina, Salmeron, Cristina, Navarro Isabel, Gutierrez, Joaquim, Isabel Navarro (462849), Daniel García de la serrana (5656525), Ramón Fontanillas (462847), García de la serrana Daniel, Jiménez-Amilburu Vanesa, García de la Serrana Castillo, Daniel, Vanesa Jiménez-Amilburu, Fontanillas Ramón, Jimenez-Amilburu, Vanesa, Ian A. Johnston, Gutiérrez Joaquim, Joaquim Gutiérrez, Capilla, Encarnacion, Ramón Fontanillas, Cristina Salmerón (462843), Gutiérrez Fruitós, Joaquín, Navarro, Isabel, Encarnación Capilla, Salmerón Cristina, Capilla Campos, Encarnación, Ian A. Johnston (39412), Johnston, Ian A., Isabel Navarro, Vanesa Jiménez-Amilburu (462845), Cristina Salmerón, Capilla Encarnación, Johnston Ian A., Jiménez-Amilburu, V., Daniel García de la serrana, Joaquim Gutiérrez (368250), Ian A Johnston, Cristina Salmerón   +38 more
core   +1 more source

Reprogramming the Immune Landscape of Inflammatory Breast Cancer

Advanced Science, EarlyView.
Inflammatory breast cancer is the most lethal subtype of breast cancer and is characterized by an immunosuppressive tumor microenvironment (TME) driven by a complex network of immune cells and inflammatory cytokines, contributing to its aggressiveness and treatment challenges. Immune checkpoint inhibitors, either alone or in combination, show potential
Verena Martinez‐Rodriguez, Suguru Ogata, Xiaoping Wang, Naoto T. Ueno   +3 more
wiley   +1 more source

Calpain inhibition promotes the rescue of F(508)del-CFTR in PBMC from cystic fibrosis patients.

PLoS ONE, 2013
A basal calpain activity promotes the limited proteolysis of wild type (WT) cystic fibrosis conductance regulator (CFTR), inducing the internalization of the split channel. This process contributes to the regulation in the level of the active CFTR at the
Monica Averna, Marco Pedrazzi, Laura Minicucci, Roberta De Tullio, Federico Cresta, Franca Salamino, Sandro Pontremoli, Edon Melloni   +7 more
doaj   +1 more source

Regulation of Cell Adhesion and Migration by Kindlin-3 Cleavage by Calpain [PDF]

Journal of Biological Chemistry, 2012
Integrin activation on hematopoietic cells is essential for platelet aggregation, leukocyte adhesion, and transmigration through endothelium and extracellular matrix into inflamed tissues. To migrate through matrix, leukocyte integrin adhesion complexes undergo dynamic changes.
Yongzhong, Zhao, Nikolay L, Malinin, Julia, Meller, Yi, Ma, Xiaoxia Z, West, Kamila, Bledzka, Jun, Qin, Eugene A, Podrez, Tatiana V, Byzova   +8 more
openaire   +2 more sources

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Calcium-dependent plasma membrane repair requires m- or μ-calpain, but not calpain-3, the proteasome, or caspases

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009
Mechanically damaged plasma membrane undergoes rapid calcium-dependent resealing that appears to depend, at least in part, on calpain-mediated cortical cytoskeletal remodeling. Cells null for Capns1, the non-catalytic small subunit present in both m- and mu-calpains, do not undergo calcium-mediated resealing.
Mellgren, Ronald L., Miyake, Katsuya, Kramerova, Irina, Spencer, Melissa J., Bourg, Nathalie, Bartoli, Marc, Richard, Isabelle, Greer, Peter A., McNeil, Paul L.   +8 more
openaire   +2 more sources

Evaluation of quantitative muscle MRI and an intelligent phenotyping housing system as advanced phenotyping methods in a mouse model of calpain 3‐deficient muscular dystrophy

Animal Models and Experimental Medicine, EarlyView.
We applied quantitative MRI of the lower limb and automated home‐cage phenotyping to a mouse model of calpainopathy to detect early disease changes. At 15 months, calpain 3‐deficient mice showed increased water T2 values correlating with immune cell infiltration in the soleus and gastrocnemius muscles, while assessment of motor activity revealed only ...
Nicolina Südkamp, Marlena Rohm, Gabriele Russo, Xavier Helluy, Abdulhadi Kocabas, Martijn Froeling, Felix Kleefeld, Denise Manahan‐Vaughan, Tobias Ruck, Frank Jacobsen, Matthias Vorgerd, Johannes Forsting, Lara Schlaffke   +12 more
wiley   +1 more source

Identification and neuroprotective properties of NA‐184, a calpain‐2 inhibitor

Pharmacology Research & Perspectives
Our laboratory has shown that calpain‐2 activation in the brain following acute injury is directly related to neuronal damage and the long‐term functional consequences of the injury, while calpain‐1 activation is generally neuroprotective and calpain‐1 ...
Michel Baudry, Yubin Wang, Xiaoning Bi, Yun Lyna Luo, Zhijun Wang, Zeechan Kamal, Alexander Shirokov, Ed Sullivan, Dennis Lagasca, Hany Khalil, Gary Lee, Kathy Fosnaugh, Philippe Bey, Shujaath Mehdi, Greg Coulter   +14 more
doaj   +1 more source