Results 71 to 80 of about 16,238 (237)

Canakinumab in the treatment of systemic juvenile idiopathic arthritis: a retrospective single center study in China

Frontiers in Pediatrics
ObjectiveSystemic juvenile idiopathic arthritis (sJIA) is characterized by excessive production of proinflammatory cytokines. As an anti-IL-1 agent, canakinumab has been approved in the USA and Europe for the treatment of sJIA patients aged ≥2 years ...
Xiaona Zhu, Ruohang Weng, Yanyan Huang, Yongbin Xu, Jun Yang, Tingyan He   +5 more
doaj   +1 more source

Increasing the Interval of Canakinumab Administration Effectively Supports the Remission of Schnitzler’s Syndrome

Case Reports in Rheumatology, 2018
Schnitzler’s syndrome (SchS) is a rare, disabling, autoinflammatory disorder characterized by recurrent urticarial rash and monoclonal IgM gammopathy. Interleukin-1 beta (IL-1β) plays an important role in the pathophysiology of SchS.
Vadim R. Gorodetskiy, Svetlana O. Salugina, Evgeny S. Fedorov   +2 more
doaj   +1 more source

Similar Clinical Outcomes in Patients with Systemic Juvenile Idiopathic Arthritis and Adult-Onset Still’s Disease Treated with Canakinumab: Bayesian and Population Model-Based Analyses [PDF]

, 2022
Cornelia Dunger‐Baldauf, Priscila Nakasato, Stephanie Noviello, Sarah Whelan, Bruno Bieth   +4 more
openalex   +1 more source

Severe Inflammation Following Vaccination Against Streptococcus pneumoniae in Patients With Cryopyrin-Associated Periodic Syndromes [PDF]

, 2016
OBJECTIVE: Pneumococcal vaccination is recommended for patients receiving immunosuppressive drugs. We describe unusually severe adverse reactions to pneumococcal vaccination in each of 7 consecutive patients with cryopyrin-associated periodic ...
Hawkins, PN, Hoffman, HM, Kuemmerle-Deschner, J, Walker, UA, Williams, R   +4 more
core  

Gene-expression analysis of adult-onset Still’s disease and systemic juvenile idiopathic arthritis is consistent with a continuum of a single disease entity [PDF]

, 2015
Background: Adult-onset Still’s disease (AOSD), a rare autoinflammatory disorder, resembles systemic juvenile idiopathic arthritis (SJIA). The superimposable systemic clinical features of AOSD and SJIA suggest both clinical phenotypes represent the same ...
Blank, Norbert, Brachat, Arndt, Feist, Eugen, Junge, Guido, Martini, Alberto, Nirmala, Nanguneri, Specker, Christof, Witt, Matthias, Zernicke, Jan   +8 more
core   +3 more sources

Inflammation, Immunity, and Cardiovascular Diseases

Med Research, EarlyView.
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo, Yan Liao, Rui Zhao, Zhaoyu Li, Kaikai Wang, Haoling Zhang, Pingxin Sun, Yadong Guo, Wangzheqi Zhang   +8 more
wiley   +1 more source

Long-Term Safety and Effectiveness of Canakinumab in Patients with MKD/HIDS: Interim Analysis of the RELIANCE Registry

Rheumatology and Therapy
Introduction Interim analysis of the long-term safety and effectiveness of canakinumab, at a patient level, in the mevalonate kinase deficiency/hyperimmunoglobulin-D syndrome (MKD/HIDS) cohort of the RELIANCE registry.
Prasad T. Oommen, Tilmann Kallinich, Juergen Rech, Norbert Blank, Julia Weber-Arden, Jasmin B. Kuemmerle-Deschner   +5 more
doaj   +1 more source

Failure of anti Interleukin-1 β monoclonal antibody in the treatment of recurrent pericarditis in two children

Pediatric Rheumatology Online Journal, 2020
Background Recurrent pericarditis (RP) is a complication (15–30%) of acute pericarditis with an unknown etiology. Treatment regimen consists of a combination of non-steroidal anti-inflammatory drugs (NSAIDs) and colchicine, with the addition of ...
Sara Signa, Matteo D’Alessandro, Rita Consolini, Angela Miniaci, Marta Bustaffa, Chiara Longo, Maria A. Tosca, Martina Bizzi, Roberta Caorsi, Leonardo Oliveira Mendonça, Andrea Pession, Angelo Ravelli, Marco Gattorno   +12 more
doaj   +1 more source

Severe Immediate and Delayed Hypersensitivity Reactions to Biologics in a Toddler With Systemic Juvenile Idiopathic Arthritis

Journal of Investigative Medicine High Impact Case Reports, 2022
Many pediatric rheumatic diseases can be safely managed with biologic therapy. Severe allergic reactions to these medications are uncommon. We report the case of a 2-year-old male with systemic-onset juvenile idiopathic arthritis and secondary macrophage
D. Sofia Villacis-Nunez MD, Kassahun Bilcha MD, Mary Spraker MD, Kelly Rouster-Stevens MD, Anthony Cooley MD   +4 more
doaj   +1 more source

Metabolic and crystal arthropathies: 112. Rapid Improvement in Health-Related Quality of Life in Gouty Arthritis Patients Treated with Canakinumab (ACZ885) Compared to Triamcinolone Acetonide [PDF]

, 2017
Background: Canakinumab, a fully human anti-IL-1β antibody has been shown to control inflammation in gouty arthritis. This study evaluated changes in health-related quality of life (HRQoL) in patients treated with canakinumab or triamcinolone acetonide ...
Arulmani, U., Arulmani, U., Balfour, A., Bodalia, B., De Meulemeester, M., De Meulemeester, M., Ferreira, A., Kerrane, J., Krammer, G., Lin, H., Murphy, V., Mysler, E., Nasonov, E., Pikhlak, A., Richard, D., Richard, D., Rovensky, J., Sallstig, P., Sallstig, P., Schlesinger, N., Schlesinger, N., So, Alexander, So, Alexander, Stricker, K., Yücel, A. E.   +24 more
core