Results 81 to 90 of about 16,238 (237)

Patient and Disease-Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics. [PDF]

, 2020
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for regenerative therapy, disease modeling, and drug discovery.
Chandy, Mark, Paik, David T, Wu, Joseph C   +2 more
core  

Feasibility randomised multicentre, double-blind, double-dummy controlled trial of anakinra, an interleukin-1 receptor antagonist versus intramuscular methylprednisolone for acute gout attacks in patients with chronic kidney disease (ASGARD): protocol study [PDF]

, 2017
Introduction: Acute gout occurs in people with chronic kidney disease, who are commonly older people with comorbidities such as hypertension, heart disease and diabetes.
Ahmed, Khalid, Almond, Mike, Balasubramaniam, Gowrie, Bhagat, Sweta, Dasgupta, Bhaskar, Harnett, Patrick, Harrison, Michael, Mallen, Christian, Marianayagam, Thiraupathy, Parker, Mike, Parker, Trisha, Pitzalis, Costantino, Roddy, Edward, Scales, Jonathan, Turner, David   +14 more
core   +2 more sources

Noise‐Induced Hearing Loss: From Pathological Mechanisms to Therapeutic Interventions

Sensory Neuroscience, EarlyView.
ABSTRACT Noise‐induced hearing loss (NIHL), a significant non‐genetic form of hearing impairment, is primarily managed through the use of hearing aids and cochlear implants. However, the fundamental pathological mechanisms underlying NIHL remain inadequately addressed.
Shiqi Huang, Yu Xiao, Jiaxin Liu, Wen Jiang, Weiwei Shi, Hanbing Zhang, Xiaolong Fu, Yunhao Wu   +7 more
wiley   +1 more source

Systematic literature review of efficacy/effectiveness and safety of current therapies for the treatment of cryopyrin-associated periodic syndrome, hyperimmunoglobulin D syndrome and tumour necrosis factor receptor-associated periodic syndrome

RMD Open, 2020
Objectives Several therapies are used for the treatment of rareautoinflammatory conditions like cryopyrin-associated periodic fever syndromes (CAPS), hyperimmunoglobulin Dsyndrome (HIDS)/mevalonate kinase deficiency (MKD) and tumour necrosis factor ...
Peter Hur, Syed Raza, Jasmin Beate Kuemmerle-Deschner, Raju Gautam, Aneesh Thomas George, Kathleen Graham Lomax   +5 more
doaj   +1 more source

Concurrent Oral 1 - Therapy of rheumatic disease: OP4. Effectiveness of Rituximab in Rheumatoid Arthritis: Results from the British Society for Rheumatology Biologics Register (BSRBR) [PDF]

, 2017
Background: Rituximab (RTX) in combination with methotrexate (MTX) has been licensed since 2006 for the management of severe active rheumatoid arthritis (RA) in patients who have failed at least one anti-tumour necrosis factor (anti-TNF) therapy ...
's Vernon, Emma, Arulmani, U., Ashcroft, Darren M., Bodalia, B., Cartwright, R., Chakravarty, Kuntal, Choy, Ernest, Christidis, Dimitrios, Cooper, Robert G., Danko, Katalin, Dasgupta, Bhaskar, De Meulemeester, M., Foeldvari, I., Gattorno, M., Genovese, Mark C., Gordon, Patrick, Griffiths, Bridget, Hachulla, E., Hakim, Alan, Hassan, Nada, Hawkins, P. N., Hoyer, J., Hyrich, Kimme L., Ibrahim, Fowzia, Incera, E., Isenberg, David, Kerrane, J., Kitas, George, Kone-Paut, I., Kowalczyk, Anna, Krammer, G., Kuemmerle-Deschner, J. B., Lachmann, H. J., Lecky, Bryan, Lepore, L., Leslie, K., Lunt, Mark, Mapplebeck, Sarah, Murphy, V., Pikhlak, A., Preiss, R., Quartier, P., Ramos, E., Richard, D., Rubbert-Roth, Andrea, Sallstig, P., Scali, Juan, Schlesinger, N., Scott, David L., Sebba, Anthony, So, Alexander, Soliman, Moetaza M., Symmons, Deborah, Vollenhoven, Ronald, Watson, Kath D., Weisbarth-Riedel, E., White-Alao, Beverley, Winer, John, Yücel, A. E., Zilberstein, Moshe, Zulian, F.   +60 more
core  

Canakinumab treatment real world evidence in 3 monogenic periodic fever syndromes in 2009–2022: an interim analysis using the French JIR cohort database

Arthritis Research & Therapy
Background Our study aimed to provide real-world evidence on the treatment patterns, effectiveness and safety of canakinumab in France in Familial Mediterranean Fever (FMF), Mevalonate Kinase Deficiency (MKD), and Tumor necrosis factor Receptor ...
Isabelle Koné-Paut, Sophie Georgin-Lavialle, Alexandre Belot, Magali Jover, Mathilde Pouriel, Laure Lacoin, Pascal Pillet, Véronique Hentgen   +7 more
doaj   +1 more source

CLINICAL CASE OF CANAKINUMAB USE IN A PATIENT WITH SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS

Педиатрическая фармакология, 2013
The article presents a case of successful use of therapeutic monoclonal antibodies to interleukin 1 (canakinumab) at severe systemic juvenile idiopathic arthritis.
R. V. Denisova, E. I. Alexeeva, T. V. Sleptsova   +2 more
doaj   +1 more source

POS0221 LONG-TERM EFFICACY AND SAFETY OF CANAKINUMAB IN PATIENTS WITH TRAPS (TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PERIODIC SYNDROME) – INTERIM ANALYSIS OF THE RELIANCE REGISTRY [PDF]

, 2022
Norbert Blank, C. Schuetz, J. Henes, T. Kallinich, P. Oommen, M. Borte, M. Hufnagel, Anita Janda, J. Weber-Arden, J. B. Kuemmerle‐Deschner   +9 more
openalex   +1 more source

Cytokines and Inflammatory Mediators [30-39]: 30. The LPS Stimulated Production of Interleukin-10 is not Associated with -819C/T and -592C/A Promoter Polymorphisms in Healthy Indian Subjects [PDF]

, 2017
Background: Interleukin-10 is a pivotal immunoregulatory cytokine with pleiotropic effects on the immune system. IL-10 promoter polymorphisms have been associated with disease susceptibility and the ability to secrete IL-10 in vitro.
Aggarwal, Amita, Braun, J., Buckley, Christopher, Buckley, Christopher D., Church, Leigh D., Collins, David A., Dawes, Peter, Douglas, Karen, Douglas, Karen M., Evans, Hayley G., Filer, Andrew D., Filer, Andrew D., Gasparyan, Armen Y., Govindan, Jyothish, Gullick, Nicola J., Hachulla, E., Hashizume, M., Hawkins, P. N., Hildago, Ester, Howlett, Katherine, Hoyer, J., Jayaraj, David, Juarez, Maria, Judah, Sunita M., Kirkham, Bruce W., Kitas, George D., Kitas, George D., Koike, N., Kolasinski, James, Kone-Paut, I., Koutedakis, Yiannis, Kuemmerle-Deschner, J. B., Lachmann, H. J., Lawrence, Able, Leslie, K., Mattey, Derek L., Metsios, Giorgos S., Mihara, M., Naik, Sita, Nixon, Nicola, Panoulas, Vasileios F., Patel, N., Preiss, R., Price, Elizabeth J., Quilter, Annette, Rapecki, Stephen, Raza, Karim, Raza, Karim, Salmon, Mike, Scheel-Toellner, Dagmar, Scheel-Toellner, Dagmar, Schmutz, Caroline, Shukla, Skanda, Smith, J., Stavropoulos-Kalinoglou, Antonios, Stavropoulos-Kalinoglou, Antonios, Suzuki, M., Taams, Leonie S., Thomas, Andrew, Toellner, Kai-Michael, Toms, Tracey E., Widmer, A., Williamson, Lyn, Yeo, Lorraine, Yoshida, H.   +64 more
core  

Dermatologic Findings of RELA‐Associated Autoinflammatory Disease

Pediatric Dermatology, EarlyView.
ABSTRACT Variants in the gene RELA have been implicated in a monogenic, hereditary form of Behcet's‐like syndrome. This case series describes the dermatologic manifestations of three patients with identified RELA‐associated autoinflammatory disease.
Elizabeth Nourse, Vidya Sivaraman, Catherine G. Chung, Shoghik Akoghlanian, Esteban Fernandez Faith   +4 more
wiley   +1 more source