The Canakinumab Antiinflammatory Thrombosis Outcome Study trial-the starting gun has fired [PDF]
, 2017 Authors work in the area has been supported by UK Medical Research Council Experimental Medicine Grant (G0502131), the National Institute for Health Research and a UK Medical Research Council Clinical Research Training Fellowship (AR -MR/K002406/1).
Crossman, David, Rothman, Alexander
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Canakinumab and cardiovascular outcomes: results of the CANTOS trial
Journal of Community Hospital Internal Medicine Perspectives, 2018 IL-1 cytokines are mainly responsible for controlling a series of pro-inflammatory reactions induced in response to pathogen mediated tissue injury. Among the IL-1 cytokine family, IL-1 β results in upregulation of genes responsible for boosting immune ...
Syed Raza Shah +6 more
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Canakinumab reverses overexpression of inflammatory response genes in tumour necrosis factor receptor-associated periodic syndrome [PDF]
, 2017 OBJECTIVE: To explore whether gene expression profiling can identify a molecular mechanism for the clinical benefit of canakinumab treatment in patents with tumour necrosis factor receptor-associated periodic syndrome (TRAPS). METHODS: Blood samples were
Abrams, K +11 more
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Treatment of adult-onset Still's disease: a review [PDF]
, 2014 Adult-onset Still's disease (AOSD) is a rare inflammatory disorder that has been recently classified as a polygenic autoinflammatory disorder. The former classification, based on the disease course, seems to be quite dated.
Gerfaud-Valentin, M. +3 more
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Post-Marketing Pharmacovigilance of Canakinumab from the FDA Adverse Event Reporting System (FAERS)
PharmaceuticalsBackground: Canakinumab, a humanized anti-IL-1β monoclonal antibody, is known for its ability to suppress IL-1β-mediated inflammation. However, continuous monitoring of its safety remains essential.
Weidong Zhang +5 more
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Педиатрическая фармакология, 2016 The article shows the observation of rare NLPC4-associated autoinflammatory syndrome with enterocolitis and familial cold urticaria. Diagnosis is confirmed molecularly-genetically: previously not described mutation c.928C>T in the heterozygous state ...
T. V. Sleptsova +9 more
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POS1376 LONG-TERM EFFICACY AND SAFETY OF CANAKINUMAB IN PATIENTS WITH HIDS (HYPER-IgD SYNDROME) - INTERIM ANALYSIS OF THE RELIANCE REGISTRY [PDF]
, 2022 Prasad T. Oommen +5 more
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Immune-mediated mechanisms of atherosclerosis and implications for the clinic. [PDF]
, 2016 A large body of evidence supports the inflammatory hypothesis of atherosclerosis, and both innate and adaptive immune responses play important roles in all disease stages.
Mallat, Ziad, Nus, Meritxell
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Schnitzler Syndrome as an Autoinflammatory Disease Driven by B‐Cell‐Specific Somatic MYD88 Mutation
Allergy, EarlyView.
Yuyi Zhou +10 more
wiley +1 more source