Results 271 to 280 of about 11,333,085 (312)

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source

Dual‐Target Nectin‐4/FAP Heterobivalent Probe 68Ga/177Lu‐FZ‐NF‐1 for Triple‐Negative Breast Cancer: Preclinical Theranostic Evaluation and First‐in‐Human Translation

Advanced Science, EarlyView.
A novel hetero‐bivalent agent, 68Ga/177Lu‐FZ‐NF‐1, concurrently targets Nectin‐4 and FAP in triple‐negative breast cancer. It yields significant preclinical tumor regression and clinically identifies additional metastatic lesions missed by 18F‐FDG PET, demonstrating promising theranostic potential for personalized management.
Ye Li, Li Sun, Xiaoyu Pan, Shuyi Lin, Dongliang Wang, Jianping Zhang, Fengshuang Qiu, Bin Zhu, Lingzhou Zhao, Fengsheng Zhang, Liyan Bai, Bingxin Gu, Xiaoping Xu, Shaoli Song   +13 more
wiley   +1 more source

In vitro models of cancer-associated fibroblast heterogeneity uncover subtype-specific effects of CRISPR perturbations. [PDF]

Mol Oncol
Saputra E, Vellarikkal SK, Li L, Sun H, Nguyen K, Montano A, Natarajan S, Piccioni F, Tamburino AM, Yu X, Olow AK.   +10 more
europepmc   +1 more source

Identification of cancer-associated fibroblast subpopulation and construction of an immunotherapy signature for gastric cancer. [PDF]

Transl Cancer Res
Wang K, Xue D, Yin C, Wang G.
europepmc   +1 more source

Cancer-Associated Fibroblast Heterogeneity Shapes Prognosis and Immune Landscapes in Head and Neck Squamous Cell Carcinoma. [PDF]

Cancers (Basel)
Takahashi H, Hagiwara H, Tada H, Uchida M, Matsuyama T, Chikamatsu K.   +5 more
europepmc   +1 more source

A tumor microenvironment integrated (TMI) staging system for pancreatic ductal adenocarcinoma based on cancer-associated fibroblast and molecular consensus signatures. [PDF]

Discov Oncol
Yeo SJ, Sim ITEE, Tay HY, Tai D, Shi R, Chan JY.   +5 more
europepmc   +1 more source

C3⁺ cancer-associated fibroblast-derived GAS6 promotes cervical cancer metastasis via activation of AXL signaling pathway in a syngeneic orthotopic mouse model. [PDF]

J Transl Med
Zhan J, Liu D, Ye J, Peng X, Liu X, Lu W, Li M, Li T, Zhong L, Zhang C.   +9 more
europepmc   +1 more source

Identification of cancer-associated fibroblast signature genes for potential biomarkers in cholangiocarcinoma: a Mendelian randomization study. [PDF]

Discov Oncol
Hu S, Chen L, Liu L, Zhang X, Xia C, Zhu Y, Zou H, Wang T.   +7 more
europepmc   +1 more source

Bulk RNA sequencing deconvolution of pancreatic ductal adenocarcinoma identifies cancer-associated fibroblast subsets associated with survival and tumor microenvironment composition

Dam N, Steketee MF, Strijk G, de Koning W, Hawinkels LJ, Kemp V, van Eijck CH, Kim Y, van Eijck CW, van Os BW.   +9 more
europepmc   +1 more source