Results 11 to 20 of about 1,018,827 (204)
Intra-tumour signalling entropy determines clinical outcome in breast and lung cancer. [PDF]
, 2015 The cancer stem cell hypothesis, that a small population of tumour cells are responsible for tumorigenesis and cancer progression, is becoming widely accepted and recent evidence has suggested a prognostic and predictive role for such cells. Intra-tumour
Banerji, CR +3 more
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Stemness, cancer, and cancer stem cells [PDF]
Cell Cycle, 2008 The ability of cancers to grow indefinitely has fueled the idea that cancer and stem cells may have common underlying mechanisms. Detailed gene expression maps have now shown the diversity and distinctiveness in gene expression programs associated with stemness in embryonic and adult stem cells. These maps have further revealed a shared transcriptional
David J, Wong +2 more
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Colorectal Cancer Stem Cells [PDF]
Diseases of the Colon & Rectum, 2009 The cancer stem cell hypothesis predicts that only a subpopulation of cells within a tumor is responsible for driving growth. If this hypothesis were true, it would have a significant impact on our current treatment of cancer because conventional chemotherapy and radiotherapy target rapidly proliferating cells making up the bulk of the tumor, not ...
Yeung, T, Mortensen, N
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WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics [PDF]
, 2009 Prostate cancer cells with stem cell characteristics were identified in human prostate cancer cell lines by their ability to form from single cells self-renewing prostaspheres in non-adherent cultures.
A de la Taille +82 more
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Cells, Stem Cells, and Cancer Stem Cells [PDF]
Seminars in Reproductive Medicine, 2013 The stem cell field owes a great deal to the previous work conducted by embryologists and researchers devoted to reproductive medicine. The time is coming when this emerging field will pay off in the reproductive sciences by offering new avenues of understanding gametogenesis and early embryonic development.
Aguilar-Gallardo, C, Simon, C
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Genome Biology, 2021 Background Deregulated gene expression is a hallmark of cancer; however, most studies to date have analyzed short-read RNA sequencing data with inherent limitations.
Kie Kyon Huang +13 more
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Lack of correlation of stem cell markers in breast cancer stem cells [PDF]
, 2014 BACKGROUND: Various markers are used to identify the unique sub-population of breast cancer cells with stem cell properties. Whether these markers are expressed in all breast cancers, identify the same population of cells, or equate to therapeutic ...
A M Thompson +49 more
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Stemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment [PDF]
Stem Cells International, 2017 Stemness combines the ability of a cell to perpetuate its lineage, to give rise to differentiated cells, and to interact with its environment to maintain a balance between quiescence, proliferation, and regeneration. While adult Stem Cells display these properties when participating in tissue homeostasis, Cancer Stem Cells (CSCs) behave as their ...
Pedro M. Aponte, Andrés Caicedo
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Cell Communication and Signaling, 2019 Background ErbB2 overexpression identifies a subset of breast cancer as ErbB2-positive and is frequently associated with poor clinical outcomes. As a membrane-embedded receptor tyrosine kinase, cell surface levels of ErbB2 are regulated dynamically by ...
Jinrui Zhang +16 more
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Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy [PDF]
, 2018 Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging.
Fabbrizi, Maria Rita +6 more
core +3 more sources