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Trends in Pharmacological Sciences, 1998 1993 represents the 100th anniversary of William Coley's first report of tumor regressions induced by immune system activation in response to bacterial toxins. While many subsequent cancer vaccine trials have yielded tantalizing results, active immunotherapy has not yet become an established modality of cancer therapy.
Drew M. Pardoll
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Hematology/Oncology Clinics of North America, 2001 Attempts to generate an anticancer immune response in vivo in patients with cancer have taken several forms. Although to date there have been relatively few published studies describing the effects of the approach in hematologic malignancy, that circumstance is expected to change rapidly during the next few years. In solid tumors, it is not known which,
Raphaël F. Rousseau +3 more
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Cancer Cell, 2022 Given the renewed interest in vaccine development sparked by the COVID-19 pandemic, we are revisiting the current state of vaccine development for cancer prevention and treatment. Experts discuss different vaccine types, their antigens and modes of action, and where we stand on their clinical development, plus the challenges we need to overcome for ...
Schiller, John T +13 more
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OncoImmunology, 2021 Human microbiota influence the response of malignancies to treatment with immune checkpoint blockade; however, their impact on other forms of immunotherapy is poorly understood.
Duo Yang +12 more
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Viruses, 2022 Human T-cell Leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATLL), HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and other inflammatory diseases.
Cynthia A. Pise-Masison +1 more
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Aging, cancer, and cancer vaccines [PDF]
Immunity & Ageing, 2012 AbstractWorld population has experienced continuous growth since 1400 A.D. Current projections show a continued increase - but a steady decline in the population growth rate - with the number expected to reach between 8 and 10.5 billion people within 40 years.
Marjorie R. Jenkins +9 more
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Nature Communications, 2023 HIV vaccine development can be aided by knowledge of correlates of protection. Here the authors identify engagement and reprogramming of tolerogenic CD14+ myeloid cells mediating a spatiotemporal balance of pro- and anti-inflammatory responses, as ...
Massimiliano Bissa +34 more
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Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation
Nature Communications, 2020 Currently there is neither a vaccine nor an effective treatment strategy available for COVID19. Here, Hurlburt et al. provide the crystal structure of a patient-derived monoclonal antibody neutralizing SARS-CoV-2 via shedding of the S1 subunit and ...
Nicholas K. Hurlburt +9 more
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Vaccines, 2023 At the heart of the DNA/ALVAC/gp120/alum vaccine’s efficacy in the absence of neutralizing antibodies is a delicate balance of pro- and anti-inflammatory immune responses that effectively decreases the risk of SIVmac251 acquisition in macaques.
Massimiliano Bissa +23 more
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Stochastic and parameter analysis for an integrative cancer model [PDF]
, 2022 In a previous work, we presented a model that integrates cancer cell differentiation and immunotherapy, analysing a particular therapy against cancer stem cells by cytotoxic cell vaccines. As every biological system is exposed to random fluctuations, it is important to study its stochasticity.
arxiv +1 more source