Results 41 to 50 of about 728,220 (269)

Identification of Key Genes Associated with Lycopene Accumulation in Red Carrot Taproots Based on WGCNA

Agronomy
Lycopene (carotenoid) is a natural pigment with strong antioxidant properties. The taproots of red carrots (Daucus carota L.) exhibit red coloration due to the presence of high levels of lycopene.
Xiaoning An, Yanan Zhang, Hang Zhang, Xinyu Zhang, Lixia Li, Dan Luo, Zhe Wu   +6 more
doaj   +1 more source

Association of NOS3 gene polymorphisms with essential hypertension in Sudanese patients: a case control study

BMC Medical Genetics, 2017
Background Essential hypertension (EH) is influenced by various environmental and genetic factors. Nitric oxide is important for the functional integrity of the vascular endothelium and is produced in endothelial cells by the enzyme endothelial nitric ...
Sahar Gamil, Jeanette Erdmann, Ihab B. Abdalrahman, Abdelrahim O. Mohamed   +3 more
doaj   +1 more source

Genetic Dissection of Phosphorous Uptake and Utilization Efficiency Traits Using GWAS in Mungbean

Agronomy, 2021
Mungbean (Vignaradiata L. Wilczek) is an early maturing legume grown predominantly in Asia for its protein-rich seeds. P deficiency can lead to several physiological disorders which ultimately result in a low grain yield in mungbean.
Venkata Ravi Prakash Reddy, Shouvik Das, Harsh Kumar Dikshit, Gyan Prakash Mishra, Muraleedhar S. Aski, Akanksha Singh, Kuldeep Tripathi, Renu Pandey, Ruchi Bansal, Madan Pal Singh, Padmavati Ganpat Gore, Manjunatha P. B., Deepali Kothari, Neha Rai, RamaKrishnan M. Nair   +14 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Integrating transcriptomics and proteomics to analyze new regulatory genes related to rice grain development

Food Chemistry: Molecular Sciences
The regulation of seed size in rice represents a significant concern within the domain of developmental biology. Nevertheless, our understanding of the mechanisms by which plants determine seed size remains limited, despite its critical importance.
Zhixuan Du, Qitao Su, Haihui Fu, Dahu Zhou, Linjuan Ouyang, Junru Fu, Haohua He   +6 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Cross-Disorder Analysis of De Novo Variants Increases the Power of Prioritising Candidate Genes

Life, 2021
De novo variants (DNVs) are critical to the treatment of neurodevelopmental disorders (NDDs). However, effectively identifying candidate genes in small cohorts is challenging in most NDDs because of high genetic heterogeneity.
Kuokuo Li, Zhengbao Ling, Tengfei Luo, Guihu Zhao, Qiao Zhou, Xiaomeng Wang, Kun Xia, Jinchen Li, Bin Li   +8 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source