Results 81 to 90 of about 728,220 (269)

Genome-Wide Association Study That Identifies Molecular Markers with Freezing Resistance in Duroc Boar Sperm

Animals
Semen cryopreservation is a crucial technology in the artificial insemination of livestock and poultry. It not only contributes to the conservation of germplasm resources but also facilitates the cross-regional exchange of high-quality breeding stock. In
Jiajun Zhang, Meicheng Li, Guangxiang Chen, Chenyu Tao, Bushe Li, Hejun Zhang, Hongyang Wang, Wenjun Wang   +7 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Aeronautical Mutagenesis and Whole-genome Resequencing Reveal the Genetic Basis of Color Change in Naematelia aurantialba

Mycobiology
Naematelia aurantialba, a rare yellow edible fungus with both nutritional and medicinal properties, is of significant importance in industrial cultivation due to its color-changing characteristics.
Yukang Zeng, Zhenhui Shen, Yao Cao, Xiangying Luo, Linlei Yang, Rongping Li, Qingqing Lu, Rongchun Li   +7 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Exome sequencing of patients with syndromic tall stature reveals four novel candidate genes

Endocrine Connections
This study aimed to evaluate a cohort of patients with syndromic tall stature of unknown etiology via exome sequencing (ES) to identify novel candidate genes for overgrowth conditions.
Gabriela Jeesoo Kim, Edoarda Vasco de Albuquerque Albuquerque, Raissa C Rezende, Laurana De Polli Cellin, Ana Maria Santillan Vasconez, Ana C V Krepischi, Lucas Santana, Antônio Marcondes Lerario, Vinicius de Souza, Renata Scalco, Alexander A L Jorge   +10 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Mining candidate genes for maize plant height based on a GWAS, Meta-QTL, and WGCNA

Frontiers in Plant Science
IntroductionIn maize, plant height (PH) is one of the most important agronomic traits that directly influences planting density and yield. Therefore, identifying candidate genes related to PH will help manipulate maize yield indirectly.MethodsThe present
Fu Qian, Zhanqin Zhang, Shubin Chen, Zhiqin Sang, Weihua Li   +4 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Identification of Biomarkers for Meat Quality in Sichuan Goats Through 4D Label-Free Quantitative Proteomics

Animals
The Nanjiang Yellow Goat (NJYG), Jintang Black Goat (JTBG), and Jianzhou Da’er Goat (JZDEG) are representative local goat breeds for meat production in Sichuan Province, China.
Rui Zhang, Mengling Xu, Rui Xu, Ting Bai, Dayu Liu, Xinhui Wang, Daodong Pan, Yin Zhang, Lin Zhang, Shifeng Pan, Jiamin Zhang   +10 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source