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Candidate gene prioritization.
Molecular genetics and genomics : MGG, 2012Candidate gene identification is typically labour intensive, involving laboratory experiments required to corroborate or disprove any hypothesis for a nominated candidate gene being considered the causative gene. The traditional approach to reduce the number of candidate genes entails fine-mapping studies using markers and pedigrees.
Ali, Masoudi-Nejad +3 more
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Testing Candidate Gene Associations
2004Abstract Suppose that by linkage analysis we have localized the chromosomal region where we believe a disease gene is located. Association studies can then be used for three main purposes: To further localize the region where the gene might be found by looking for additional markers that are in strong LD with the ...
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