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Journal of Animal Breeding and Genetics, 2010
Lehden pääkirjoitus ; v ; 2011 ...
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Lehden pääkirjoitus ; v ; 2011 ...
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SNPing Away at Candidate Genes
Genetic Epidemiology, 2001We develop regression methodology to identify subsets of single nucleotide polymorphisms (SNPs) within candidate genes related to quantitative traits and apply our methods to the simulated Genetic Analysis Workshop (GAW) 12 data set. In the data set we find 694 SNP loci with minimum allele frequencies of at least 0.01.
M A, Suchard +3 more
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Candidate Genes for Osteoporosis
American Journal of PharmacoGenomics, 2001Osteoporosis, which afflicts 10 million Americans, is a complex disease characterized by decreased bone mass, microarchitectural deterioration of bone tissue, and an increase in fracture risk. Family and twin studies have established a genetic contribution to the etiology of osteoporosis.
T, Niu, X, Xu
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Candidate Genes for Insulin Resistance
Diabetes Care, 1996Insulin resistance confers increased susceptibility to NIDDM, atherosclerotic cardiovascular disease, ovarian hyperandrogenism, and possibly hypertension. Insulin resistance is largely inherited, in rare cases as a monogenic disorder or more commonly as a complex trait.
D E, Moller, C, Bjørbaek, A, Vidal-Puig
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Pharmacogenetic Candidate Genes for Melanoma
Pharmacogenomics, 2003The incidence of melanoma is rising at an alarming rate and has become an important public health concern. If detected early, melanoma carries an excellent prognosis after appropriate surgical resection. Unfortunately, advanced melanoma has a poor prognosis and is notoriously resistant to radiation and chemotherapy.
Christopher, Hull +2 more
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Candidate Gene Association Analysis
2009Candidate gene association study is the most common method for associating human genetic variations with the phenotypes they produce, due to the relative simplicity of acquiring patient samples and genotype data. The study design begins with identifying appropriate DNA samples and an appropriate phenotype for analysis.
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Polymorphisms in Candidate Asthma Genes
The American Journal of the Medical Sciences, 2001The triad of reversible airway obstruction, bronchial hyperresponsiveness, and airway inflammation characterizes asthma. The etiology of asthma is complex and involves the interaction of multiple genetic foci and a variety of environmental factors, such as protein allergens, chemical sensitizers, and viral or bacterial proteins.
U, Nanavaty, A D, Goldstein, S J, Levine
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