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Candidate genes for behavioural ecology
Trends in Ecology & Evolution, 2005In spite of millions of years of evolutionary divergence, the conservation of gene function is common across distant lineages. As such, genes that are known to influence behaviour in one organism are likely to influence similar behaviours in other organisms.
Fitzpatrick, M.J. +5 more
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Candidate Gene Association Studies
2010Candidate gene association studies aim to establish or characterise association between the genetic -variation occurring within a specific gene or locus and a phenotype. If the phenotype is quantitative, then the effect size is often measured as the difference between the genotype specific means or a per allele effect.
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Candidate Genes in Eating Disorders
Current Drug Target -CNS & Neurological Disorders, 2003Environmental influences, as well as biological and genetic factors influence risk for eating disorders. Family and twin studies have shown that eating disorders are familial and suggest the influence of genetic factors on their etiology. Positive associations have been observed for some candidate genes that have been studied (such as 5HT2A receptor ...
Federica, Tozzi, Cynthia M, Bulik
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Candidate gene case-control studies
Pharmacogenomics, 2003Two main approaches to the identification of genes are involved in polygenic diseases. Use of family studies has generally been the preferred approach up until recently, but this is only feasible if the genetic component of the disease is relatively strong and DNA samples are available from other family members.
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Candidate gene prioritization.
Molecular genetics and genomics : MGG, 2012Candidate gene identification is typically labour intensive, involving laboratory experiments required to corroborate or disprove any hypothesis for a nominated candidate gene being considered the causative gene. The traditional approach to reduce the number of candidate genes entails fine-mapping studies using markers and pedigrees.
Ali, Masoudi-Nejad +3 more
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
exaly
Testing Candidate Gene Associations
2004Abstract Suppose that by linkage analysis we have localized the chromosomal region where we believe a disease gene is located. Association studies can then be used for three main purposes: To further localize the region where the gene might be found by looking for additional markers that are in strong LD with the ...
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