Results 81 to 90 of about 43,946 (263)

Ultra‐refractory epilepsy: The newly described entity

Epilepsia Open, EarlyView.
Abstract Objective Drug‐resistant epilepsy (DRE) is defined as the failure of two antiseizure medications (ASMs) to achieve complete seizure control, affecting approximately 30% of epilepsy patients. In some cases, additional ASMs and surgical approaches are also unsuccessful.
Jan Vinklárek, Petra Búřilová, Mojdeh Raouf Zadeh, Eva Zatloukalová, Jitka Kočvarová, Ondřej Strýček, Martin Pail, Klára Štillová, Jan Chrastina, Eva Brichtová, Andrea Pokorná, Dana Mazánková, Milan Brázdil, Irena Doležalová   +13 more
wiley   +1 more source

Pharmacokinetic Interaction of Kratom and Cannabidiol in Male Rats

Pharmaceutics
Kratom and cannabidiol products are used to self-treat a variety of conditions, including anxiety and pain, and to elevate mood. Research into the individual pharmacokinetic properties of commercially available kratom and cannabidiol products has been ...
Erin C. Berthold, Shyam H. Kamble, Siva Rama Raju Kanumuri, Michelle A. Kuntz, Alexandria S. Senetra, Yi-Hua Chiang, Sushobhan Mukhopadhyay, Christopher R. McCurdy, Abhisheak Sharma   +8 more
doaj   +1 more source

Cannabidiol in autism: Clinical pharmacology priorities for trial design

British Journal of Clinical Pharmacology, EarlyView.
Gislei Frota Aragão, Carla Barbosa Brandão, José Evaldo Leandro Júnior   +2 more
wiley   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

A systematic review and meta-analysis of the haemodynamic effects of cannabidiol [PDF]

, 2017
Despite cannabidiol (CBD) having numerous cardiovascular effects in vitro, its haemodynamic effects in vivo are unclear. Nonetheless, the clinical use of CBD (Epidiolex) is becoming more widespread.
Abati, Adams, Alvarez, Alves, Belgrave, Bergamaschi, Bhattacharyya, Bhattacharyya, Booz, Borgen, Borgwardt, Bright, Bright, Capasso, Chagas, Consroe, Consroe, Crippa, Crippa, Cunha, Devinsky, Durst, Egger, England, Feng, Fusar-Poli, Garberg, Geffrey, Gomes, Gomes, Gonca, Gong, Granjeiro, Hallak, Hayakawa, Hayakawa, Hayakawa, Higgins, Hind, Iuvone, Leweke, Martin-Santos, Mishima, Nadulski, Nadulski, O'Sullivan, Pazos, Pertwee, Pertwee, Rajesh, Rajesh, Resstel, Resstel, Rosenkrantz, Ruiz-Valdepenas, Russo, Stanley, Stanley, Stanley, Stroke Therapy Academic Industry Roundtable, Tambaro, Thomas, Tomida, Walsh, Wheal, Winton-Brown, Zuardi, Zuardi, Zuardi   +68 more
core   +1 more source

Adverse Effects of Oral Cannabidiol: An Updated Systematic Review of Randomized Controlled Trials (2020–2022) [PDF]

, 2022
José Diogo R. Souza, Júlia Cozar Pacheco, Giordano Novak Rossi, Bruno O. de-Paulo, Antônio Waldo Zuardi, Francisco Silveira Guimarães, Jaime E. C. Hallak, José Alexandre S. Crippa, Rafael G. dos Santos   +8 more
openalex   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Cannabidiol binding and negative allosteric modulation at the cannabinoid type 1 receptor in the presence of delta-9-tetrahydrocannabinol: An In Silico study.

PLoS ONE, 2019
Recent evidence has raised in discussion the possibility that cannabidiol can act as a negative allosteric modulator of the cannabinoid type 1 receptor. Here we have used computational methods to study the modulation exerted by cannabidiol on the effects
Hery Chung, Angélica Fierro, C David Pessoa-Mahana   +2 more
doaj   +1 more source

Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models [PDF]

, 2019
Objective Epilepsy is a progressive neurological disease characterized by recurrent seizures and behavioral comorbidities. We investigated the antiseizure effect of cannabidiol (CBD), in a battery of acute seizure models.
Barker-Haliski, Melissa, Bazelot, Michael, Glyn, Sarah, Jones, Nicholas, McNeish, Alister James, Patra, Pabitra H., Sandhu, Haramrit, Whalley, Benjamin J., White, H. Steve, Williams, Claire M.   +9 more
core   +4 more sources

Microfluidic Synthesis of Hyaluronic Acid Microgels in a Coaxial Flow Reactor

Macromolecular Materials and Engineering, EarlyView.
A coaxial flow reactor allows continuous production of hyaluronic microgels with efficient parameter optimisation through Design‐of‐Experiments. ABSTRACT Microgels combine the strengths of hydrogels and microparticles. The multiple advantages of microgels, including control of drug release, excellent loading efficiency, high stability, and ...
Shuting Li, Xinyuan Jia, Duncan Q. M. Craig, Rachael Dickman, Michael T. Cook   +4 more
wiley   +1 more source