Results 181 to 190 of about 74,377 (332)

Defining the Intestinal eCBome and Oxylipin Signaling Systems in a TDP‐43 Mouse Model of Frontotemporal Dementia

open access: yesThe FASEB Journal, Volume 40, Issue 2, 31 January 2026.
TDP‐43 overexpressing mice, a genetic model of frontotemporal dementia, exhibit dramatic changes in their small intestinal endocannabinoidome members, in terms of both altered concentrations of lipid mediators and expression of some of their receptors (Cnr1, Gpr119, Gpr55, Pparg) and metabolic enzymes (Napepld, Faah). Also, the levels of some oxylipins
Hayatte‐Dounia Mir   +9 more
wiley   +1 more source

Type-1 Cannabinoid Receptor Promiscuous Coupling: Computational Insights into Receptor-G Protein Interaction Dynamics. [PDF]

open access: yesInt J Mol Sci
Berghella A   +7 more
europepmc   +1 more source

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing

open access: yesAdvanced Science, Volume 13, Issue 2, 9 January 2026.
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen   +5 more
wiley   +1 more source

Efficacy and safety of a selective partial agonist for nociception/orphanin‐FQ peptide (NOP) receptors in patients with insomnia disorder

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 172-185, January 2026.
Aims Insomnia is a common sleep disorder, affecting up to 20% of the world population and adversely impacting productivity, health, and overall well‐being. Although pharmacologic options exist to treat insomnia, the health‐related quality of life for patients who are prescribed hypnotics is no higher than for those who are not, revealing a significant ...
Garth T. Whiteside   +5 more
wiley   +1 more source

Naringin Alleviates Autistic-Like Behaviors in BTBR Mice Through Cannabinoid Receptor Type 1-Mediated Restoration of Hippocampal Neurogenesis. [PDF]

open access: yesCNS Neurosci Ther
Liu Y   +12 more
europepmc   +1 more source

Stress Switches Cannabinoid Type-1 (CB1) Receptor-Dependent Plasticity from LTD to LTP in the Bed Nucleus of the Stria Terminalis [PDF]

open access: bronze, 2013
Christelle Glangetas   +5 more
openalex   +1 more source

Scent Goes Digital: The Role of Insect Odorant Binding Proteins in Modern Technology

open access: yesBioFactors, Volume 52, Issue 1, January/February 2026.
This review delves into bioinspired olfactory biosensors, focusing on insect odorant binding proteins (OBPs) as core elements of hybrid bionic platforms for volatile compound detection. Highlighting the development of the biological electronic nose (BE‐NOSE), it examines current prototypes, outlines advantages over conventional methods, and explores ...
Maddalena Ventura   +5 more
wiley   +1 more source

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