Entomological consequences and toxicological detection of synthetic cannabinoid receptor agonists (SCRAs) in necrophagous larvae (Diptera: Calliphoridae). [PDF]
Blavier CAK +6 more
europepmc +1 more source
Plant‐Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two‐Component System
Plant‐derived melatonin is sensed by CpxAE48/T51, which inhibits the phosphorylation cascade transmission from CpxAH240 to CpxRD52, resulting in the inhibition of DNA‐binding capacity of CpxR and subsequent T3SS genes expression in Pst DC3000. ABSTRACT In defending against pathogens, plants deploy diverse secondary metabolites and signaling molecules ...
Jin‐Wei Wei +7 more
wiley +1 more source
Synthesis and Pharmacological Characterization of a Novel Cannabinoid Receptor 1 Antagonist. [PDF]
Bengoetxea de Tena I +13 more
europepmc +1 more source
Effect of plant population on crop growth, floral biomass, and cannabinoid yield in field‐grown hemp
Abstract Hemp (Cannabis sativa L.) was recently re‐legalized in the United States and cultivated for various purposes, including floral cannabidiol (CBD), grain, and fiber. Due to prohibition of hemp for a century, research supporting production guidelines, including plant density effects on CBD production, remains limited.
Richard J. Roseberg +2 more
wiley +1 more source
Crystal structures of agonist-bound human cannabinoid receptor CB<sub>1</sub>. [PDF]
Hua T +18 more
europepmc +1 more source
Channel Dysfunction as the Basis for Comorbidities in Multiple Sclerosis and Depression
Ion channel remodelling induced by neuroinflammation in multiple sclerosis alters neuronal excitability and immune signalling, creating shared molecular pathways that link multiple sclerosis pathology to depression and reveal novel pharmacological targets.
Nicole Rychlik +4 more
wiley +1 more source
Cannabinoid Receptor 2 (CB2) in Macrophages: A Promising Clinical Target for Immune Disorders. [PDF]
Yoon HH, Grimsey NL.
europepmc +1 more source
Abstract Aims Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...
Andriy A. Gorbenko +9 more
wiley +1 more source
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale +5 more
wiley +1 more source
Naringin Alleviates Autistic-Like Behaviors in BTBR Mice Through Cannabinoid Receptor Type 1-Mediated Restoration of Hippocampal Neurogenesis. [PDF]
Liu Y +12 more
europepmc +1 more source

