Results 181 to 190 of about 41,551 (306)

LIPID RAFTS, CB2 RECEPTOR SIGNALING AND METABOLISM OF 2-ARACHIDONOYL-GLYCEROL IN HUMAN IMMUNE CELLS

, 2006
Recently we have shown that treatment of rat C6 glioma cells with the membrane cholesterol depletor and raft disruptor methyl-β-cyclodextrin (MCD) doubles the binding of anandamide (AEA) to type-1 cannabinoid receptors (CB1R), followed by CB1R-dependent ...
ODDI, Sergio, Finazzi Agrò A, Fezza F, Gasperi V, Spagnuolo P, Maccarrone M., Bari M, Pasquariello N   +7 more
core  

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Activation of Cannabinoid Receptor 1 Enhances Wound Healing by Promoting the Proliferative Phase. [PDF]

Int J Mol Sci
Cui HS, Zheng YX, Cho YS, Jung YG, Kwak IS, Ro YM, Joo SY, Kim JB, Seo CH.   +8 more
europepmc   +1 more source

Maternal Deaths Due to Suicide, Accidental Poisoning and Undetermined Intent Within 5 Years Following Childbirth: A Population‐Based Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 8, Page 1581-1591, July 2026.
ABSTRACT Objectives Investigate the incidence of maternal deaths by suicide, accidental poisoning and undetermined intent within 5 years following childbirth. Design Linked population‐level data. Setting New South Wales, Australia. Population All women who gave birth from 2002 to 2020. Methods Sociodemographic characteristics, diagnostic and healthcare
Louise Makarious, Ju Lee Oei, Andrew Page, Sadia Hossain, Mithilesh Dronavalli, Hannah Uebel, Evelyn Lee, Michelle Dickson, Lucinda Burns, Barbara Bajuk, John Eastwood, Sithum Munasinghe   +11 more
wiley   +1 more source

Cannabidiphorol (CBDP) acts as a negative allosteric modulator at two distinct sites of cannabinoid receptor 1. [PDF]

Commun Chem
Pandey P, Zagzoog AH, Zaharia T, Chatterjee S, Khan IA, Paris JJ, Laprairie RB, Chittiboyina AG.   +7 more
europepmc   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, Volume 183, Issue 14, Page 3970-3991, July 2026.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Acute metabolic effects of cannabinoid receptor modulators during sequential hyperglycemic, euglycemic-hyperinsulinemic clamps in healthy individuals. [PDF]

Am J Physiol Endocrinol Metab
Chia CW, Tang EY, Cutler RG, You SS, Chen Q, Choo AYM, Melvin DL, Ramsden CE, Kapogiannis D, Egan JM.   +9 more
europepmc   +1 more source

Defining AV2‐1 as a novel pharmacological probe to target human and rodent TRPV2

British Journal of Pharmacology, Volume 183, Issue 13, Page 3538-3557, July 2026.
Abstract Background and Purpose Transient receptor potential vanilloid 2 (TRPV2) is a non‐selective cation channel implicated in immune cell functions. However, progress in understanding TRPV2 has been limited by a lack of potent and selective pharmacological tools, particularly those targeting the human variant. We aimed to identify and characterise a
Andrea Leipe, Julia A. Rocereta, Ruth A. Pumroy, Andreas Leffler, Michael Schaefer, Vera Moiseenkova‐Bell, Kerstin Hill   +6 more
wiley   +1 more source

Targeting mechanosensitive cannabinoid receptor 1 with isoflavone prodrugs attenuates atherosclerotic endothelial dysfunction. [PDF]

J Biomed Sci
Chung DJ, Chen SP, Liu WH, Liu CY, Su NW, Hsu C, Tsai HY, Yang KC, Wu CK, Lin SW, Shie JJ, Zhao MT, Wei TT.   +12 more
europepmc   +1 more source

Health, Social and Recidivism Outcomes Among People Who Have Been Incarcerated in New South Wales, Australia: Study Protocol and Cohort Profile for the Prison Outcomes STudy (POST)

Drug and Alcohol Review, Volume 45, Issue 5, July 2026.
ABSTRACT Introduction We have been funded to examine post‐incarceration health and social outcomes for all people incarcerated in New South Wales, Australia, 2000–2022; assess treatment and services for drug dependence and serious mental illness; and project the impact of expanding intervention coverage. We will use a linked cohort, the Prison Outcomes
Louisa Degenhardt, Michael Farrell, Michael Doyle, Jack Stone, Chrianna Bharat, Matt Hickman, Marianne Martinello, Don Weatherburn, Kimberlie Dean, Joe Coyte, Christel Macdonald, Mary Ellen Harrod, Luke Grant, Gloria Larman, Peter Vickerman, Colette McGrath, Peter Thompson, Alison Churchill, Greg Dore, Thomas Santo Jr   +19 more
wiley   +1 more source