Results 201 to 210 of about 74,377 (332)

Clinical Outcomes and Patient Profiles in the UK Medical Cannabis Registry: A k‐Means Clustering Analysis

The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract There is a paucity of high‐quality evidence on the clinical efficacy of cannabis‐based medicinal products (CBMPs). The objective of this study was to perform trajectory k‐means clustering of health‐related quality of life (HRQoL) outcomes in patients prescribed CBMPs to identify distinct response patterns and baseline predictors of treatment ...
Simon Erridge, Evonne Clarke, Katy McLachlan, Ross Coomber, Sushil Beri, Shaheen Khan, Mark W. Weatherall, Michael W. Platt, James J. Rucker, Pedro A. M. Mediano, Mikael H. Sodergren   +10 more
wiley   +1 more source

Activity of protein kinase C controls the efficacy of cannabinoid receptor type 1 in the medial prefrontal cortex after neuropathic pain. [PDF]

J Neurophysiol
Chao D, Liu Y, Cheng T, Hogan QH, Pan B.
europepmc   +1 more source

Reduced Antinociceptive Effect of Repeated Treatment with a Cannabinoid Receptor Type 2 Agonist in Cannabinoid-Tolerant Rats Following Spinal Nerve Transection

, 2012
Shashank Matthew, Christian Ndong, Russell P. Landry, A.D. Joyce, Eduardo C. Alfonso   +4 more
openalex   +1 more source

Constitutive Activation Drives Compartment-Selective Endocytosis and Axonal Targeting of Type 1 Cannabinoid Receptors [PDF]

, 2006
Christophe Leterrier, Jeanne Lainé, Michèle Darmon, Hélène Boudin, Jean Rossier, Zsolt Lenkei   +5 more
openalex   +1 more source

Lifestyle and Behavioural Intervention Therapy for Enhanced Hippocampal Neuroplasticity

Lifestyle Medicine, Volume 7, Issue 1, January 2026.
ABSTRACT Background The neurogenic and neuroplastic capability of the brain plays a crucial role in mitigating responses to internal and external environmental stimuli. However, this process is inhibited in obesity, neurodegenerative and psychological disorders, the prevalence of which has increased on a global scale.
Ebrahim Samodien, Sylvester Ifeanyi Omoruyi, Brendon Pearce, Melisse Erasmus, Nireshni Chellan   +4 more
wiley   +1 more source

Characterization of binding kinetics and intracellular signaling of new psychoactive substances targeting cannabinoid receptor using transition-based reweighting method. [PDF]

Elife
Dutta S, Shukla D.
europepmc   +1 more source

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source

Opposing Synovial Cannabinoid Receptor Type 2 and Transient Receptor Potential Vanilloid 1 Expression in Painful Osteoarthritis. [PDF]

Cureus
Toups CA, Guillot LG, Redondo K, Jensen S, Klein J, Marrero L.   +5 more
europepmc   +1 more source

Activity‐restoring mutations in the histamine H3 receptor increase constitutive activity and reduce structural stability

Protein Science, Volume 35, Issue 1, January 2026.
Abstract The histamine H3 receptor (H3R) is a class A G protein‐coupled receptor (GPCR) that regulates neurotransmitter release in the central nervous system. Although structures of H3R in both inactive and active states have been elucidated, the functional roles of specific residues remain unclear.
Ami Nakajima, Hiroto Kaneko, Kosuke Oyama, Misumi Kuchiji, Ayane Itakura, Chiaki Arai, Mitsunori Shiroishi   +6 more
wiley   +1 more source

Development of Carborane-Based Benzothiazole Analogues as Cannabinoid Receptor Type 2 (CB₂R) Ligands. [PDF]

ACS Omega
Ueberham L, Kazimir A, Deuther-Conrad W, Hey-Hawkins E.   +3 more
europepmc   +1 more source