Results 31 to 40 of about 247,999 (295)

Is there a potential of misuse for Magnolia officinalis compounds/metabolites? [PDF]

, 2017
© 2017 John Wiley & Sons, Ltd.Objective: Magnolia bark contains magnolol, metabolized to tetrahydromagnolol and honokiol, with both GABA-ergic/cannabimimetic activities, hence of possible attraction to vulnerable individuals/recreational misusers ...
Alexeev, Böhmdorfer, Chiou, Coppola, Fattore, Fuchs, Fuchs, Garrison, Hattori, Kalman, Kao, Kotani, Kuribara, Lee, Lee, Lin, Liu, Mantani, Nakazawa, Oikawa, Papanti, Rempel, Schifano, Schifano, Schifano, Siemann, Sohn, Squires, Tsai, Tsai, Wang, Watanabe, Xu   +32 more
core   +3 more sources

Allosteric modulation of adenosine A1 and cannabinoid 1 receptor signaling by G‐peptides

Pharmacology Research & Perspectives, 2020
While allosteric modulation of GPCR signaling has gained prominence to address the need for receptor specificity, efforts have mainly focused on allosteric sites adjacent to the orthosteric ligand‐binding pocket and lipophilic molecules that target ...
Anja M. Touma, Rabia U. Malik, Tejas Gupte, Sivaraj Sivaramakrishnan   +3 more
doaj   +1 more source

Allosteric Modulation: An Alternate Approach Targeting the Cannabinoid CB1 Receptor [PDF]

Medicinal Research Reviews, 2017
AbstractThe cannabinoid CB1 receptor is a G protein coupled receptor and plays an important role in many biological processes and physiological functions. A variety of CB1 receptor agonists and antagonists, including endocannabinoids, phytocannabinoids, and synthetic cannabinoids, have been discovered or developed over the past 20 years.
Thuy-Ai T Nguyen, Jun-Xu Li, B. Thomas, J. Wiley, T. Kenakin, Yanan Zhang   +5 more
semanticscholar   +3 more sources

On the G-protein-coupled receptor heteromers and their allosteric receptor-receptor interactions in the central nervous system: focus on their role in pain modulation [PDF]

, 2013
The modulatory role of allosteric receptor-receptor interactions in the pain pathways of the Central Nervous System and the peripheral nociceptors has become of increasing interest.
Agnati, Luigi F, Borroto-Escuela, Dasiel O, Fuxe, Kjell, Rivera, Alicia, Romero-Fernandez, Wilber, Tarakanov, Alexander O, Van Craenenbroeck, Kathleen   +6 more
core   +3 more sources

Modulation of Nicotinic Receptors by Cannabinoids

The FASEB Journal, 2018
The legalization of medicinal and recreational use of marijuana by many states in the USA, has resulted in an increase in its use. The two most abundant phytocannabinoids in marijuana Δ 9 ‐Tetrahydrocannabinol (THC) and cannabidiol (CBD) have been shown to have tremendous therapeutic ...
Carla Sofia Rodriguez‐Tirado, Jose Orlando Colon‐Saez, Jose Lasalde‐Dominicci   +2 more
openaire   +1 more source

Cannabinoid Receptor–Interacting Protein 1a Modulates CB1 Receptor Signaling and Regulation [PDF]

Molecular Pharmacology, 2015
Cannabinoid CB1 receptors (CB1Rs) mediate the presynaptic effects of endocannabinoids in the central nervous system (CNS) and most behavioral effects of exogenous cannabinoids. Cannabinoid receptor-interacting protein 1a (CRIP1a) binds to the CB1R C-terminus and can attenuate constitutive CB1R-mediated inhibition of Ca(2+) channel activity.
Smith, TH, Blume, LC, Straiker, A, Cox, JO, David, BG, Mcvoy, JRS, Sayers, KW, Poklis, JL, Abdullah, RA, Egertova, M, Chen, C-K, Mackie, K, Elphick, MR, Howlett, AC, Selley, DE   +14 more
openaire   +3 more sources

The therapeutic potential of allosteric ligands for free fatty acid sensitive GPCRs [PDF]

, 2013
G protein coupled receptors (GPCRs) are the most historically successful therapeutic targets. Despite this success there are many important aspects of GPCR pharmacology and function that have yet to be exploited to their full therapeutic potential.
Hudson, Brian D., Milligan, Graeme, Ulven, Trond   +2 more
core   +1 more source

Allosteric Modulators of the CB1 Cannabinoid Receptor: A Structural Update Review

Cannabis and Cannabinoid Research, 2016
In 2005, the first evidence of an allosteric binding site at the CB1R was provided by the identification of three indoles of the company Organon that were allosteric enhancers of agonist binding affinity and, functionally, allosteric inhibitors of ...
P. Morales, P. Goya, N. Jagerovic, L. Hernández‐Folgado   +3 more
semanticscholar   +1 more source

CB1 Receptor Antagonism Blocks Stress-Potentiated Reinstatement of Cocaine Seeking in Rats [PDF]

, 2015
Rationale Under some conditions, stress, rather than directly triggering cocaine seeking, potentiates reinstatement to other stimuli, including a subthreshold cocaine dose.
Baker, David A., Doncheck, Elizabeth M., Ganzman, Geoffrey S., Hillard, Cecilia J., Mantsch, John R., McReynolds, Jayme R., Vranjkovic, Oliver   +6 more
core   +2 more sources

Enhanced Anandamide Plasma Levels in Patients with Complex Regional Pain Syndrome following Traumatic Injury: A Preliminary Report [PDF]

, 2009
The complex regional pain syndrome (CRPS) is a disabling neuropathic pain condition that may develop following injuries of the extremities. The pathogenesis of this syndrome is not clear; however, it includes complex interactions between the nervous and ...
Campolongo, P., Chouker, A., Hauer, D., Huge, V., Kaufmann, I., Schelling, G., Thiel, M., Vogeser, M.   +7 more
core   +1 more source