Results 41 to 50 of about 247,999 (295)

Targeting cannabinoid CB2 receptors in the Central Nervous System. Medicinal chemistry approaches with focus on neurodegenerative disorders

Frontiers in Neuroscience, 2016
Endocannabinoids activate two types of specific receptors, namely cannabinoid CB1 and CB2. Contrary to the psychotropic actions of agonists of CB1 receptors, and serious side effects of the selective antagonists of this receptor, drugs acting on CB2 ...
Gema Navarro, Paula Morales, Carmen Rodríguez-Cueto, Javier Fernández-Ruiz, Nadine Jagerovic, Rafael Franco   +5 more
doaj   +1 more source

Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CB2R)

Frontiers in Chemistry, 2022
It is well known that G protein–coupled receptors (GPCRs) assume multiple active states. Orthosteric ligands and/or allosteric modulators can preferentially stabilize specific conformations, giving rise to pathway-biased signaling.
Rebecca Ferrisi, Francesca Gado, Francesca Gado, Beatrice Polini, Caterina Ricardi, Kawthar A. Mohamed, Lesley A. Stevenson, Gabriella Ortore, Simona Rapposelli, Giuseppe Saccomanni, Roger G. Pertwee, Robert B. Laprairie, Robert B. Laprairie, Clementina Manera, Clementina Manera, Grazia Chiellini, Grazia Chiellini   +16 more
doaj   +1 more source

Genetic Background Can Result in a Marked or Minimal Effect of Gene Knockout (GPR55 and CB2 Receptor) in Experimental Autoimmune Encephalomyelitis Models of Multiple Sclerosis [PDF]

, 2013
PMCID ...
A Compston, A Shetty, A Zimmer, AC Howlett, AE Bygrave, C Bolton, C Delarasse, C Delarasse, C Teuscher, Carolyn Tanner, CS Wu, CS Wu, D Baker, D Baker, D Baker, D Baker, D Baker, D Baker, D Baker, D McHugh, David Baker, David L. Selwood, DL Smith-Bouvier, E de Lago, E Kozela, E Montero, E Zurita, F Docagne, F Wu, G Disanto, G Musumeci, G Paltser, G Pryce, G Pryce, G Wotherspoon, Gareth Pryce, Gavin Giovannoni, Gregory J. Michael, H Kataoka, HM Vesterinen, I Mendel, J Corey-Bloom, J Karlsson, J Palazuelos, JA Encinas, JB Davis, JH Slingsby, JK O'Neill, JL Croxford, JL Croxford, JM Coquet, JP Zajicek, K Li, K Maresz, KM Spach, L Cristino, LM Olsson, LS Whyte, M Sundvall, M Webb, MF Festing, NA Balenga, NE Buckley, O Ofek, PC Staton, PD Fillmore, PM Hoi, RA Ross, RA Ross, RC Axtell, RG Pertwee, RG Pertwee, RJ Butterfield, Roberto Furlan, RS Graves, Ruth A. Ross, S Al-Izki, S Al-Izki, S Amor, S Amor, S Amor, S Katona, S Levine, S Levine, S Rossi, S Saadoun, Samuel J. Jackson, SC Landis, SJ Allen, Sofia Sisay, V Devonshire, Y Okuda, ZY Lou   +92 more
core   +3 more sources

Experimental Cannabinoid 2 Receptor-Mediated Immune Modulation in Sepsis [PDF]

Mediators of Inflammation, 2014
Sepsis is a complex condition that results from a dysregulated immune system in response to a systemic infection. Current treatments lack effectiveness in reducing the incidence and mortality associated with this disease. The endocannabinoid system offers great promise in managing sepsis pathogenesis due to its unique characteristics. The present study
J. Sardinha, M. E. M. Kelly, J. Zhou, C. Lehmann   +3 more
openaire   +3 more sources

The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg

IBRO Neuroscience Reports, 2022
Childhood absence epilepsy (CAE) is a non-convulsive seizure disorder primarily in children characterized by absence seizures. Absence seizures consist of 2.5–5 Hz spike-and-wave discharges (SWDs) detectable using electroencephalography (EEG).
Dan L. McElroy, Andrew J. Roebuck, Quentin Greba, Sumanta Garai, Asher L. Brandt, Orhan Yilmaz, Stuart M. Cain, Terrance P. Snutch, Ganesh A. Thakur, Robert B. Laprairie, John G. Howland   +10 more
doaj   +1 more source

Cannabinoids and Dementia: A Review of Clinical and Preclinical Data [PDF]

, 2010
The endocannabinoid system has been shown to be associated with neurodegenerative diseases and dementia. We review the preclinical and clinical data on cannabinoids and four neurodegenerative diseases: Alzheimer’s disease (AD), Huntington’s disease (HD),
Aarsland, Aiken, Allen, Aso, Bal-Price, Bambico, Basavarajappa, Bellocchio, Benito, Benito, Blennow, Breivogel, Campbell, Campillo, Cao, Carroll, Centonze, Cernak, Citron, Consroe, Consroe, Cummings, Curtis, Curtis, Curtis, de Lago, De March, Denovan-Wright, Di Marzo, Di Marzo, Ehrhart, Esposito, Esposito, Esposito, Esposito, Eubanks, Fernandez-Espejo, Fernandez-Ruiz, Ferri, Fox, Gaoni, Garcia-Arencibia, Gerdeman, Gilgun-Sherki, Glass, Glass, Glass, Glass, Grunblatt, Gubellini, Hansen, Hayakawa, Herkenham, Hillard, Howlett, Howlett, Iuvone, Iuvone, Jimenez-Del-Rio, Katona, Katona, Katona, Kelsey, Khaspekov, Kirshner, Krishnan, Kumar, Lastres-Becker, Lastres-Becker, Lastres-Becker, Lastres-Becker, Lastres-Becker, Lastres-Becker, Lastres-Becker, Lees, Leker, Leys, Louw, Maneuf, Mangieri, Marchalant, Marchalant, Maresz, Marsicano, Matsuda, Mauler, McCaw, Meschler, Mesnage, Michael Halpern, Milton, Molina-Holgado, Morgese, Muller-Vahl, Munro, Murillo-Rodriguez, Murillo-Rodriguez, Nagayama, Pacher, Palazuelos, Parmentier-Batteur, Passmore, Pavese, Pellegrini-Giampietro, Pertwee, Price, Ramirez, Richfield, Sapp, Savva, Sebastian Walther, Shen, Shen, Sieradzan, Silverdale, Staekenborg, Tai, Tolon, van der Stelt, van der Stelt, van Vliet, Venderova, Volicer, Walker, Walsh, Walter, Walther, Wegener, Westlake, Wilson, Zani, Zhu, Zuardi   +132 more
core   +2 more sources

The Endocannabinoid System and Oligodendrocytes in Health and Disease

Frontiers in Neuroscience, 2018
Cannabinoid-based interventions are being explored for central nervous system (CNS) pathologies such as neurodegeneration, demyelination, epilepsy, stroke, and trauma. As these disease states involve dysregulation of myelin integrity and/or remyelination,
Alexander A. Ilyasov, Alexander A. Ilyasov, Carolanne E. Milligan, Carolanne E. Milligan, Emily P. Pharr, Emily P. Pharr, Allyn C. Howlett, Allyn C. Howlett   +7 more
doaj   +1 more source

An Autonomous Cannabinoid System in Islets of Langerhans

Frontiers in Endocrinology, 2021
While endocannabinoids (ECs) and cannabis were primarily studied for their nervous system effects, it is now clear that ECs are also produced in the periphery where they regulate several physiological processes, including energy storage, glucose and ...
Kanikkai Raja Aseer, Josephine M. Egan
doaj   +1 more source

Cannabinoid receptor 1 positive allosteric modulator (GAT229) attenuates cisplatin-induced neuropathic pain in mice

Saudi Pharmaceutical Journal, 2023
Chemotherapy-induced peripheral neuropathy (CIPN) is one of chemotherapies’ most often documented side effects. Patients with CIPN experience spontaneous burning, numbness, tingling, and neuropathic pain in their feet and hands.
Amina M. Bagher, Lenah S. Binmahfouz, Rasheed A. Shaik, Basma G. Eid   +3 more
doaj   +1 more source

Phenotype-Based Screening of Synthetic Cannabinoids in a Dravet Syndrome Zebrafish Model. [PDF]

, 2020
Dravet syndrome is a catastrophic epilepsy of childhood, characterized by cognitive impairment, severe seizures, and increased risk for sudden unexplained death in epilepsy (SUDEP).
Anvar, Mana, Baraban, Scott C, Griffin, Aliesha, Hamling, Kyla   +3 more
core   +1 more source