Results 51 to 60 of about 247,999 (295)
Pharmacological Or Genetic Targeting Of Transient Receptor Potential (TRP) Channels Can Disrupt The Planarian Escape Response [PDF]
, 2019 In response to noxious stimuli, planarians cease their typical ciliary gliding and exhibit an oscillatory type of locomotion called scrunching. We have previously characterized the biomechanics of scrunching and shown that it is induced by specific ...
Cochet-Escartin, O. +5 more
core +3 more sources
The development and therapeutic potential of classical and next-generation cannabinoid ligands
Pharmacological ResearchThe endogenous cannabinoid system (ECS) is a complex network that plays a crucial role in various physiological processes, and its modulation through cannabinoid ligands has garnered significant interest in pharmacological research. Cannabinoid receptors,
Verónica Muñoz-Canales +4 more
doaj +1 more source
Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling
Frontiers in Molecular Neuroscience, 2019 In addition to its known actions as a non-selective cyclooxygenase (COX) 1 and 2 inhibitor, we hypothesized that indomethacin can act as an allosteric modulator of the type 1 cannabinoid receptor (CB1R) because of its shared structural features with the ...
Robert B. Laprairie +9 more
doaj +1 more source
Frontiers in Behavioral Neuroscience, 2021 Anxiety disorder is a well-recognized condition observed in subjects submitted to acute stress. Although the brain mechanisms underlying this disorder remain unclear, the available evidence indicates that oxidative stress and GABAergic dysfunction ...
Waldo Lucas Luz +14 more
doaj +1 more source
Endocannabinoids and the Processing of Value-Related Signals [PDF]
, 2012 Endocannabinoids serve as retrograde signaling molecules at many synapses within the CNS, particularly GABAergic and glutamatergic synapses. Synapses onto midbrain dopamine (DA) neurons in the ventral tegmental area (VTA) make no exception to this rule ...
Miriam eMelis +6 more
core +2 more sources
Allosteric Modulation of Cannabinoid Receptor 1—Current Challenges and Future Opportunities
International Journal of Molecular Sciences, 2019 The cannabinoid receptor type 1 (CB1R), a G protein-coupled receptor (GPCR), plays an essential role in the control of many physiological processes such as hunger, memory loss, gastrointestinal activity, catalepsy, fear, depression, and chronic pain ...
S. Hryhorowicz +6 more
semanticscholar +1 more source
What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel? [PDF]
, 2013 Transient receptor potential (TRP) ion channels are emerging as a new set of membrane proteins involved in a vast array of cellular processes and regulated by a large number of physical and chemical stimuli, which involves them with sensory cell ...
Doñate-Macian, Pau +2 more
core +1 more source
A patent update on cannabinoid receptor 1 antagonists (2015-2018)
Expert Opinion on Therapeutic Patents, 2019 Introduction: The endocannabinoid system is an important regulator of various physiological processes. Preclinical and clinical studies indicate that attenuation of the endocannabinoid system via antagonism of the type 1 cannabinoid receptor (CB1) is an ...
G. Amato, N. Khan, Rangan Maitra
semanticscholar +1 more source
Polyunsaturated fatty acid-derived lipid mediators and T cell function [PDF]
, 2014 Copyright © 2014 Nicolaou, Mauro, Urquhart and Marelli-Berg . This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY) .
Marelli-Berg, F +3 more
core +3 more sources
Current Topics in Medicinal Chemistry, 2019 The cannabinoid receptor 1 (CBR1) is involved in a variety of physiological pathways and has long been considered a golden target for therapeutic manipulation.
Thuy-Ai T Nguyen, B. Thomas, Yanan Zhang
semanticscholar +1 more source