Results 81 to 90 of about 247,999 (295)
Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks
British Journal of Clinical Pharmacology, EarlyView.The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou +2 more
wiley +1 more source
CB1 Receptor Negative Allosteric Modulators as a Potential Tool to Reverse Cannabinoid Toxicity
MoleculesWhile the opioid crisis has justifiably occupied news headlines, emergency rooms are seeing many thousands of visits for another cause: cannabinoid toxicity.
Audrey Flavin +10 more
doaj +1 more source
Emerging therapies for the treatment of osteoporosis
Journal of Mid-Life Health, 2013 Osteoporosis is a chronic disease of the osseous system characterized by decreased bone strength and increased fracture risk. It is due to an imbalance in the dynamic ongoing processes of bone formation and bone resorption.
Garima Bhutani, Mahesh Chander Gupta
doaj +1 more source
The use of a quantitative structure-activity relationship (QSAR) model to predict GABA-A receptor binding of newly emerging benzodiazepines [PDF]
, 2018 The illicit market for new psychoactive substances is forever expanding. Benzodiazepines and their derivatives are one of a number of groups of these substances and thus far their number has grown year upon year.
Haegeman, Caroline +4 more
core +5 more sources
Sentience in cephalopod molluscs: an updated assessment
Biological Reviews, EarlyView.ABSTRACT This article evaluates the evidence for sentience – the capacity to have feelings – in cephalopod molluscs: octopus, cuttlefish, squid, and nautilus. Our framework includes eight criteria, covering both whether the animal's nervous system could support sentience and whether their behaviour indicates sentience.
Alexandra K. Schnell +4 more
wiley +1 more source
Frontiers in Psychiatry, 2014 Over the last decades the endocannabinoid system has been implicated in a large variety of functions, including a crucial modulation of brain reward circuits and the regulation of motivational processes.
George ePanagis +2 more
doaj +1 more source
Calcium-independent inhibitory G-protein signaling induces persistent presynaptic muting of hippocampal synapses [PDF]
, 2011 Adaptive forms of synaptic plasticity that reduce excitatory synaptic transmission in response to prolonged increases in neuronal activity may prevent runaway positive feedback in neuronal circuits.
Chang, Chun Yun +3 more
core +2 more sources
Drug Testing and Analysis, EarlyView.New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley +1 more source
TRPV1 and Endocannabinoids: Emerging Molecular Signals that Modulate Mammalian Vision
Cells, 2014 Transient Receptor Potential Vanilloid 1 (TRPV1) subunits form a polymodal cation channel responsive to capsaicin, heat, acidity and endogenous metabolites of polyunsaturated fatty acids.
Daniel A. Ryskamp +3 more
doaj +1 more source
High hopes for cannabinoid agonists in the treatment of rheumatic diseases [PDF]
, 2014 There are two well-characterised isoforms of cannabinoid receptor; CB(1) and CB(2) and of these CB(2) is under active investigation as a potential target for treatment of the chronic pain associated with widespread and intractable joint diseases ...
Barrett-Jolley, Richard +2 more
core +1 more source