Results 1 to 10 of about 396,548 (332)
Stem Cells, 2020 Cardiac differentiation of embryonic stem cells (ESCs) can give rise to de novo chamber cardiomyocytes and nodal pacemaker cells. Compared with our understanding of direct differentiation toward atrial and ventricular myocytes, the mechanisms for nodal ...
W. Liang +8 more
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Multiple Targets of the Canonical WNT/β-Catenin Signaling in Cancers
Frontiers in Oncology, 2019 Canonical WNT/β-catenin signaling is involved in most of the mechanisms that lead to the formation and development of cancer cells. It plays a central role in three cyclic processes, which are the cell division cycle, the immune cycle, and circadian ...
Yves Lecarpentier +4 more
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Canonical Wnt signaling regulates Mbd3 protein stability during neurogenesis [PDF]
Experimental and Molecular MedicineAcquisition of neural progenitor cell (NPC) homeostasis through balancing self-renewal and differentiation is essential for brain development and function.
Nhu Thi Quynh Mai +2 more
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eLife, 2019 Non-canonical Wnt signaling plays a central role for coordinated cell polarization and directed migration in metazoan development. While spatiotemporally restricted activation of non-canonical Wnt-signaling drives cell polarization in epithelial tissues,
Daniel Čapek +5 more
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Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Ovarian cancer is a malignant tumor of the female reproductive system with the highest mortality, and involves the aberrant regulation of multiple molecular signaling pathways.
ZHOU Wanzhen, TENG Yincheng
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Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications
Nature Reviews Cardiology, 2022 WNT signalling comprises a diverse spectrum of receptor-mediated pathways activated by a large family of WNT ligands and influencing fundamental biological processes. WNT signalling includes the β-catenin canonical pathway and the non-canonical pathways,
I. Akoumianakis +2 more
semanticscholar +1 more source
Roles of Non-Canonical Wnt Signalling Pathways in Bone Biology
International Journal of Molecular Sciences, 2021 The Wnt signalling pathway is one of the central signalling pathways in bone development, homeostasis and regulation of bone mineral density. It consists of numerous Wnt ligands, receptors and co-receptors, which ensure tight spatiotemporal regulation of
Jasna Lojk, J. Marc
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Newly Constructed Network Models of Different WNT Signaling Cascades Applied to Breast Cancer Expression Data. [PDF]
PLoS ONE, 2015 WNT signaling is a complex process comprising multiple pathways: the canonical β-catenin-dependent pathway and several alternative non-canonical pathways that act in a β-catenin-independent manner.
Michaela Bayerlová +5 more
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Ligand-independent canonical Wnt activity in canine mammary tumor cell lines associated with aberrant LEF1 expression. [PDF]
PLoS ONE, 2014 Pet dogs very frequently develop spontaneous mammary tumors and have been suggested as a good model organism for breast cancer research. In order to obtain an insight into underlying signaling mechanisms during canine mammary tumorigenesis, in this study
Ana Gracanin +7 more
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Non-canonical Wnt Signaling Promotes Myofibroblast Differentiation in Pulmonary Fibrosis.
American Journal of Respiratory Cell and Molecular Biology, 2021 The Wnt/β-catenin pathway initiates a signaling cascade critical in cell differentiation and normal development of multiple organ systems. The reactivation of this pathway has been documented in experimental and human idiopathic pulmonary fibrosis (IPF),
Tianju Liu +4 more
semanticscholar +1 more source