Results 11 to 20 of about 396,548 (332)
Surrogate Wnt agonists that phenocopy canonical Wnt/β-catenin signaling [PDF]
Nature, 2017 Wnt proteins modulate cell proliferation and differentiation and the self-renewal of stem cells by inducing β-catenin-dependent signalling through the Wnt receptor frizzled (FZD) and the co-receptors LRP5 and LRP6 to regulate cell fate decisions and the ...
C. Y. Janda +16 more
semanticscholar +5 more sources
Wnt Glycation Inhibits Canonical Signaling [PDF]
Cells, 2019 Glycation occurs as a non-enzymatic reaction between amino and thiol groups of proteins, lipids, and nucleotides with reducing sugars or α-dicarbonyl metabolites.
Zhennan Ye +5 more
doaj +3 more sources
Wnt Signaling Upregulates Teneurin-3 Expression via Canonical and Non-canonical Wnt Pathway Crosstalk [PDF]
Frontiers in Neuroscience, 2019 Teneurins (Tens) are a highly conserved family of proteins necessary for cell-cell adhesion. Tens can be cleaved, and some of their proteolytic products, such as the teneurin c-terminal associated-peptide (TCAP) and the intracellular domain (ICD), have ...
Sussy Bastías-Candia +7 more
doaj +3 more sources
Canonical Wnt Signaling Protects Hippocampal Neurons from Aβ Oligomers: Role of Non-Canonical Wnt-5a/Ca2+ in Mitochondrial Dynamics [PDF]
Frontiers in Cellular Neuroscience, 2013 Alzheimer´s disease (AD) is the most common type of age-related dementia. The disease is characterized by a progressive loss of cognitive abilities, severe neurodegeneration, synaptic loss and mitochondrial dysfunction.
Carmen eSilva-Alvarez +5 more
doaj +8 more sources
Postepy biochemii, 2019 The canonical Wnt pathway is related to regulation of embryogenesis, cell differentiation and proliferation. Various proteins are necessary for proper signal transduction and β-catenin serves as the main mediator.
R. Kleszcz
semanticscholar +3 more sources
Cellular Signalling, 2020 The Wnt signaling pathway is a crucial regulator of the intestinal epithelium homeostasis and is altered in most colon cancers. While the role of aberrant canonical, β-catenin-dependent Wnt signaling has been well established in colon cancer promotion, much less is known about the role played by noncanonical, β-catenin-independent Wnt signaling in this
E. Flores-Hernández +8 more
semanticscholar +3 more sources
Canonical and Non-Canonical Wnt Signaling in Immune Cells. [PDF]
Trends in Immunology, 2018 Cell differentiation, proliferation, and death are vital for immune homeostasis. Wnt signaling plays essential roles in processes across species. The roles of Wnt signaling proteins and Wnt ligands have been studied in the past, but the context-dependent mechanisms and functions of these pathways in immune responses remain unclear.
W. Chae, A. Bothwell
semanticscholar +3 more sources
Blood advances, 2021 Myeloid dysplastic syndrome (MDS) reflects a preleukemic bone marrow (BM) disorder with limited treatment options and poor disease survival. As only a minority of MDS patients are eligible for curative hematopoietic stem cell transplantation, there is an urgent need to develop alternative treatment options.
Krimpenfort, Rosa A, Nethe, Micha
openaire +3 more sources
Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling [PDF]
Nature Communications, 2014 Wnt proteins control diverse biological processes through β-catenin-dependent canonical signalling and β-catenin-independent non-canonical signalling. The mechanisms by which these signalling pathways are differentially triggered and controlled are not fully understood.
Ren Sheng +10 more
openaire +4 more sources
Macrophages mediate a switch between canonical and non-canonical Wnt pathways in canine mammary tumors. [PDF]
PLoS ONE, 2014 OBJECTIVE:According to the current hypothesis, tumor-associated macrophages (TAMs) are "corrupted" by cancer cells and subsequently facilitate, rather than inhibit, tumor metastasis.
Magdalena Król +13 more
doaj +1 more source