Results 21 to 30 of about 396,548 (332)
eLife, 2020 Frizzleds (Fzd) are the primary receptors for Wnt morphogens, which are essential regulators of stem cell biology, yet the structural basis of Wnt signaling through Fzd remains poorly understood.
N. Tsutsumi +12 more
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Canonical Wnt signaling in systemic sclerosis [PDF]
Laboratory Investigation, 2016 Fibrosing disorders are characterized by abundant accumulation of extracellular matrix proteins such as collagen in a variety of organs, which results in structural changes and dysfunction of the affected organ. Thus fibrotic diseases are characterized by a high morbidity and mortality and also lead to major socioeconomic costs. Systemic sclerosis (SSc)
Christina, Bergmann, Jörg H W, Distler
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Canonical Wnt Signaling Sets the Pace [PDF]
Developmental Cell, 2019 In this issue of Developmental Cell, Ren et al. (2019) identify the embryonic origin of cardiac pacemaker cells in zebrafish and implicate Wnt5b in promoting their differentiation. Furthermore, canonical Wnt activation in human stem cell-derived cardiac progenitors produces functional pacemaker cells in vitro, advancing the therapeutic potential of ...
C Geoffrey, Burns, Caroline E, Burns
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Both canonical and non-canonical Wnt signaling independently promote stem cell growth in mammospheres. [PDF]
PLoS ONE, 2014 The characterization of mammary stem cells, and signals that regulate their behavior, is of central importance in understanding developmental changes in the mammary gland and possibly for targeting stem-like cells in breast cancer.
Alexander M Many, Anthony M C Brown
doaj +1 more source
The structural biology of canonical Wnt signalling [PDF]
Biochemical Society Transactions, 2020 The Wnt signalling pathways are of great importance in embryonic development and oncogenesis. Canonical and non-canonical Wnt signalling pathways are known, with the canonical (or β-catenin dependent) pathway being perhaps the best studied of these.
Mark Agostino, Sebastian Öther-Gee Pohl
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Premise and peril of Wnt signaling activation through GSK-3β inhibition
iScience, 2022 Summary: Wnt signaling pathways have been extensively studied in the context of several diseases, including cancer, coronary artery disease, and age-related disorders.
Samuel M. Law, Jie J. Zheng
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PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling [PDF]
The EMBO Journal, 2011 Wnt signalling is an evolutionarily conserved pathway that directs cell-fate determination and morphogenesis during metazoan development. Wnt ligands are secreted glycoproteins that act at a distance causing a wide range of cellular responses from stem cell maintenance to cell death and cell proliferation. How Wnt ligands cause such disparate responses
Peradziryi, Hanna +6 more
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Disease Models & Mechanisms, 2011 SUMMARY Despite available therapies, myocardial infarction (MI) remains a leading cause of death worldwide. Better understanding of the molecular and cellular mechanisms that regulate cardiac repair should help to improve the clinical outcome of MI ...
Omonigho Aisagbonhi +5 more
doaj +1 more source
FKBP5 Induces Senescence in BMSCs and Inhibits Osteogenic Differentiation Through the Canonical WNT/β-Catenin Signalling Pathway in Senile Osteoporosis. [PDF]
J Cell Mol MedZhu B +5 more
europepmc +3 more sources
Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells
Molecular Cancer, 2009 Background β-catenin mutations that constitutively activate the canonical Wnt signaling have been observed in a subset of hepatocellular carcinomas (HCCs).
Yilmaz Mustafa +11 more
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