Results 101 to 110 of about 145,423 (282)

Site-Specific N-Glycosylation on the AAV8 Capsid Protein

Viruses, 2018
Adeno associated virus (AAV) is a versatile gene delivery tool, which has been approved as a human gene therapy vector for combating genetic diseases. AAV capsid proteins are the major components that determine the tissue specificity, immunogenicity and ...
Arya Aloor, Junping Zhang, Ebtesam A. Gashash, Aishwarya Parameswaran, Matthew Chrzanowski, Cheng Ma, Yong Diao, Peng George Wang, Weidong Xiao   +8 more
doaj   +1 more source

Capsid protein heterogeneity in turnip mosaic virus

Virology, 1976
Abstract The effect of capsid protein heterogeneity on various virus properties in purified turnip mosaic virus was investigated. Polyacrylamide-gel electrophoresis in the presence of sodium dodecyl sulfate (SDS) revealed three distinct capsid protein species, designated as fast form (MW 27,000), intermediate form (MW 29,000), slow form (MW 36,000 ...
Plant Pathology Department, University of Florida, Gainesville, Florida 32611 USA ( host institution ), Hiebert, Ernest, McDonald, J.G.   +2 more
openaire   +3 more sources

Surfactant‐Enhanced Electrospun Nanofiber Filters for Efficient Viral and Bacterial Inactivation

Journal of Applied Polymer Science, EarlyView.
In this work, electrospun polyacrylonitrile (PAN) nanofibrous filters functionalized with surfactants (CTAB, CPC, and SDS) were developed for air filtration applications. The PAN nanofiber mats enable efficient particulate matter capture while simultaneously providing antimicrobial and antiviral activity against bacteria (E. coli and S.
Edilton N. da Silva, Paulo A. M. Chagas, Gustavo C. da Mata, Felipe A. Lima, Fabiana B. Furtado, Wanderley P. de Oliveira, Rejane M. T. Grotto, Clovis W. O. de Souza, Mônica L. Aguiar, Vádila G. Guerra   +9 more
wiley   +1 more source

Using computational approaches to study dengue virus capsid assembly

Computational and Mathematical Biophysics, 2019
Dengue viral capsid plays a significant role in viral life cycle of dengue, especially in vial genome protection and virus-cell fusion. Revealing mechanisms of the viral capsid protein assembly may lead to the discovery of anti-viral drugs that inhibit ...
Salas Gicela G Saucedo, Hernandez Alan E Lopez, He Jiadi, Karki Chitra, Xie Yixin, Sun Shengjie, Xian Yuejiao, Li Lin   +7 more
doaj   +1 more source

L2, the minor capsid protein of papillomavirus

Virology, 2013
The capsid protein L2 plays major roles in both papillomavirus assembly and the infectious process. While L1 forms the majority of the capsid and can self-assemble into empty virus-like particles (VLPs), L2 is a minor capsid component and lacks the capacity to form VLPs. However, L2 co-assembles with L1 into VLPs, enhancing their assembly.
Wang, Joshua W., Roden, Richard B.S.
openaire   +2 more sources

Identification Epitope on VP4 Protein of Senecavirus A Recognized by a Monoclonal Antibody

Animal Research and One Health, EarlyView.
This study aims to identify conserved antigenic epitopes on the SVA VP4 protein using monoclonal antibodies, providing valuable tools for further exploring its functions and developing detection methods. SVA VP4 protein was expressed in Escherichia coli and purified with High‐Affinity Ni‐Charged Resin FF.
Liang Meng, Xuyan Xiang, Xinyu Qi, Hanrong Zhou, Peiyu Xiao, Fandan Meng, Tongqing An, Haiwei Wang   +7 more
wiley   +1 more source

The Merkel Cell Polyomavirus Minor Capsid Protein

PLoS Pathogens, 2013
The surface of polyomavirus virions is composed of pentameric knobs of the major capsid protein, VP1. In previously studied polyomavirus species, such as SV40, two interior capsid proteins, VP2 and VP3, emerge from the virion to play important roles during the infectious entry process.
Rachel M Schowalter, Christopher B Buck
openaire   +4 more sources

Adaptive Machine Learning Framework for Optimizing the Affinity Purification of Adeno‐Associated Viral Vectors

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Adeno‐associated viral (AAV) vectors for gene therapy are becoming integral to modern medicine, providing therapeutic options for diseases once deemed incurable. Currently, viral vector purification is a critical bottleneck in the gene therapy industry, impacting product efficacy and safety as well as accessibility and cost to patients ...
Kelvin P. Idanwekhai, Shriarjun Shastry, Morgan R. Hurst, Arianna Minzoni, Eduardo Barbieri, Luke Remmler, Eugene N. Muratov, Michael A. Daniele, Stefano Menegatti, Alexander Tropsha   +9 more
wiley   +1 more source

Proteolytic Processing ofChlorellaVirus CVK2 Capsid Proteins

Virology, 1997
Chlorella virus CVK2 particles contain several capsid proteins that are selectively released by treatment with 4 M urea. Seven of them (Vp52, Vp45, Vp41, Vp25, Vp20.5, Vp20, and Vp16.2) have been identified based on amino acid sequences at the N-terminus.
SONGSRI, PUTTAPORN, HIRAMATSU, SHINGO, FUJIE, MAKOTO, YAMADA, TAKASHI   +3 more
openaire   +2 more sources

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source