Results 101 to 110 of about 5,586,089 (360)

Structural and Biochemical Characterization of a Widespread Enterobacterial Peroxidase Encapsulin

Advanced Science, EarlyView.
Encapsulins are self‐assembling bacterial protein compartments loaded with cargo enzymes. The most abundant encapsulin cargo class are Dye‐decolorizing Peroxidases (DyPs). In this study, we structurally and biochemically characterize a DyP encapsulin found in many enterobacteria.
Natalia C. Ubilla‐Rodriguez, Michael P. Andreas, Tobias W. Giessen   +2 more
wiley   +1 more source

Effect of coat-protein concentration on the self-assembly of bacteriophage MS2 capsids around RNA [PDF]

arXiv, 2023
Self-assembly is a vital part of the life cycle of certain icosahedral RNA viruses. Furthermore, the assembly process can be harnessed to make icosahedral virus-like particles (VLPs) from coat protein and RNA in vitro. Although much previous work has explored the effects of RNA-protein interactions on the assembly products, relatively little research ...
arxiv  

Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α

eLife, 2016
Restriction factors and pattern recognition receptors are important components of intrinsic cellular defenses against viral infection. Mammalian TRIM5α proteins are restriction factors and receptors that target the capsid cores of retroviruses and ...
Jonathan M Wagner, Marcin D Roganowicz, Katarzyna Skorupka, Steven L Alam, Devin Christensen, Ginna Doss, Yueping Wan, Gabriel A Frank, Barbie K Ganser-Pornillos, Wesley I Sundquist, Owen Pornillos   +10 more
doaj   +1 more source

Capsid and Procapsid Proteins of a Bovine Enterovirus

Journal of General Virology, 1971
Summary A bovine enterovirus (serotype VG-5-27) was grown in BHK 21 cells and purified using gel filtration and sedimentation procedures. Infective particles sedimented at 165s and the empty capsids or procapsids at 75s. Proteins extracted from each type of component were separated by polyacrylamide-gel electrophoresis.
S. J. Martin, M. D. Johnston
openaire   +3 more sources

Structural polymorphism of the major capsid protein of rotavirus [PDF]

The EMBO Journal, 2001
Rotaviruses are important human pathogens with a triple-layered icosahedral capsid. The major capsid protein VP6 is shown here to self-assemble into spherical or helical particles mainly depending upon pH. Assembly is inhibited either by low pH (100 mM) of divalent cations (Ca(2+) and Zn(2+)).
Lepault, J., Petitpas, Isabelle, Erk, I., Navaza, J., Bigot, Donna-Joe, Dona, M., Vachette, P., Cohen, J., Rey, F.A.   +8 more
openaire   +5 more sources

Virome and Experimental Analysis Reveal Tryptophan‐Like Dissolved Organic Matter Contributes to the Persistence of Plant Viruses in River Water

Advanced Science, EarlyView.
Tryptophan‐like dissolved organic matter (Try‐like DOM), a key component of organic matter in river ecosystems, demonstrates significant protective effects against plant viruses. The protective mechanism operates via a “swimming firewall” mode, whereby free Try‐like DOM attenuates ultraviolet (UV) radiation and scavenges reactive oxygen species ...
Yujie Wang, Ming Chen, Liu Yang, Jun Ma, Jian Tang, Shengjun Wu, Chi He, J. Paul Chen   +7 more
wiley   +1 more source

Near-atomic structure of a giant virus

Nature Communications, 2019
Nucleocytoplasmic large DNA viruses are a group of viruses that infect many eukaryotic hosts. Here, the authors provide a 3.5 Å resolution icosahedrally-averaged capsid structure of Paramecium bursaria chlorella virus 1 and show how 1800 minor capsid ...
Qianglin Fang, Dongjie Zhu, Irina Agarkova, Jagat Adhikari, Thomas Klose, Yue Liu, Zhenguo Chen, Yingyuan Sun, Michael L. Gross, James L. Van Etten, Xinzheng Zhang, Michael G. Rossmann   +11 more
doaj   +1 more source

Venezuelan Equine Encephalitis Virus Capsid—The Clever Caper

Viruses, 2017
Venezuelan equine encephalitis virus (VEEV) is a New World alphavirus that is vectored by mosquitos and cycled in rodents. It can cause disease in equines and humans characterized by a febrile illness that may progress into encephalitis.
Lindsay Lundberg, Brian Carey, Kylene Kehn-Hall   +2 more
doaj   +1 more source

Evolutionary and structural analyses of alpha-papillomavirus capsid proteins yields novel insights into L2 structure and interaction with L1

Virology Journal, 2008
BackgroundPVs (PV) are small, non-enveloped, double-stranded DNA viruses that have been identified as the primary etiological agent for cervical cancer and their potential for malignant transformation in mucosal tissue has a large impact on public health.
J. Lowe, Debasis Panda, Suzanne L. Rose, T. Jensen, W. Hughes, F. Tso, P. Angeletti   +6 more
semanticscholar   +1 more source

Recent Advances in mRNA Delivery Systems for Cancer Therapy

Advanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang, Ya‐Nan Fan, Si‐Qi Jiang, Ya‐Jing Ma, Yao‐Ru Yu, Yu‐Xin Qing, Qian‐Ru Li, Yi‐Lin Liu, Song Shen, Jun Wang   +9 more
wiley   +1 more source