Results 171 to 180 of about 832,259 (254)

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

iPSC-derived CAR-NK extracellular vesicles for non-small cell lung cancer: evidence, engineering, and translational barriers. [PDF]

Front Immunol
Liang Z, Zhao X, Jiang M, Zhou M, Liu S, Zhao Y.   +5 more
europepmc   +1 more source

Coexpression of GITRL confers resistance to Treg cell-mediated immunosuppression to anti-CD19 CAR-NK cells. [PDF]

Front Immunol
Schmidt D, Ebrahimabadi S, Tirapelle MC, Garcia Ferreira CM, Dos Santos MH, Biggi AF, da Silva Januário ME, Calado RT, Picanço-Castro V.   +8 more
europepmc   +1 more source

Safety and Feasibility of Infusing Ex Vivo Expanded Allogeneic Canine Natural Killer Cells for the Treatment of Metastatic Solid Tumours

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Companion canines need advances in therapeutic options for solid tumour malignancies. Natural killer (NK) cell infusions offer a promising treatment modality in canines with solid tumours. Autologous natural killer products are limited by dysfunctional immunity and a manufacturing process that delays care whereas allogeneic NK cells offer the ...
Allison M. Weisnicht, Fernanda Szewc, Monica Moonkyung Cho, Han‐Yun Hannah Cheng, Swetha Ganesh, Lauren Mahoney, Kathryn Fox, Portia R. Smith, Mallery Olsen, Rebecca M. Richards, David M. Vail, Christian M. Capitini   +11 more
wiley   +1 more source

Distinct neural input strategies to motor units in the soleus and medial gastrocnemius during quiet standing

The Journal of Physiology, EarlyView.
Abstract figure legend Motor unit spike trains were decomposed from high‐density surface electromyograms recorded from the medial gastrocnemius (MG; left, in red) muscle and soleus (SOL; right, in blue). To compare the neural input to the spinal motoneurons between them, we quantified the intramuscular coherence (IMC) of motor unit spike trains within ...
Hiroki Arakawa, Naotsugu Kaneko, Nadaka Hakariya, Hikaru Yokoyama, Kimitaka Nakazawa   +4 more
wiley   +1 more source

Depletion of IL-10 in CAR-NK cells augments reprogramming of the tumor microenvironment and ameliorates therapeutic efficacy. [PDF]

Mol Ther Oncol
Löwe A, Röder J, Häcker A, Bhatti A, Mijatovic M, Müller N, Schnieder M, Kiefer A, Kühnel I, Tonn T, Kaulich M, Stein S, Zhang C, Weigert A, Wels WS.   +14 more
europepmc   +1 more source

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

Preclinical efficacy of iPSC-derived MUC1-targeted CAR-NK cells against esophageal squamous cell carcinoma. [PDF]

Cancer Immunol Immunother
Peng Y, Guan T, Xiao Y, Lin S, Wu J, Lin Y, Wang J, Zeng H, Ma C.   +8 more
europepmc   +1 more source

Symptom‐Based Machine Learning Framework for Early Syndrome Coronavirus 2 (SARS‐CoV‐2) Infection Prediction

Applied AI Letters, Volume 8, Issue 1, February 2027.
This graphical abstract illustrates a symptom‐based machine learning framework for early prediction of SARS‐CoV‐2 infection. Clinical inputs such as SpO2, fever, cough, fatigue, and comorbidities are collected and preprocessed, followed by feature selection using a random forest‐based recursive elimination method.
Abdul Manan Koli, Syed Immamul Ansarullah, Ab Rashid Dar, Khair Ul Nisa, Anurag Sinha, Sami Alshmrany, Ravi Shankar Kumar, Mohd Asif Shah, Shreyash Srivastva, Amar Jeet   +9 more
wiley   +1 more source

CAR-NK cell therapy for hematologic malignancies: advances, challenges and optimization strategies. [PDF]

Mol Cancer
Liu W, Miao H, Weng L, Cao X.
europepmc   +1 more source