Results 181 to 190 of about 30,272 (291)

Novel Bispecific Engagers Targeting the CεmX Domain of mIgE‐Expressing Cells

Allergy, EarlyView.
We developed bispecific TCE & NKCE targeting the CεmX domain of mIgE to eliminate IgE‐producing cells. Both constructs demonstrated potent, specific, dose‐dependent cytotoxicity and selective immune activation in vitro. These results highlight their promise as off‐the‐shelf, potentially curative therapeutics for IgE‐associated allergic diseases ...
Constantin Möller, Julia Hambach, Alessa Zoe Schaffrath, Thomas Eden, Sophia Cichutek, Anna Josephine Gebhardt, Natalie Tode, Ronald Maitschke‐Rajasekharan, Philipp Lewe, Sharon Qi, Susanne Witt, Marie Eggers, Nicola M. Tomas, Friedrich Haag, Friedrich Koch‐Nolte, Boris Fehse, Kristoffer Riecken   +16 more
wiley   +1 more source

Rapid CAR screening and circRNA-driven CAR-NK cells for persistent shed-resistant immunotherapy. [PDF]

Signal Transduct Target Ther
Chung JY, Hong J, Yee SM, Lim HW, Lee D, Yoon S, Lee SH, Jung Y, Shin SH, Kim SC, Lee CH, Jang M.   +11 more
europepmc   +1 more source

OPTIMIZING INTRACELLULAR SIGNALING DOMAINS FOR CAR-NK CELLS

Hematology, Transfusion and Cell Therapy, 2020
J.T.C. Azevedo, R.N. Silvestre, A.M. Pessoni, K.C.R. Malmegrim, D.T. Covas, V. Picanço-Castro   +5 more
openaire   +2 more sources

Using peri‐operative patient‐ and parent‐reported experience and outcome measures to identify paediatric postsurgical recovery trajectories: an observational cohort study

Anaesthesia, EarlyView.
Summary Introduction Identifying postoperative pain trajectories and pre‐operative risk factors may support preventative measures and enhance pain management. We aimed to determine the feasibility of gathering peri‐operative data from families of children, describe their recovery trajectories and identify risk factors for high postsurgical pain ...
Samantha Pang, Nicholas West, Haoyu Zhao, Jessica Luo, Neil K. Chadha, Lynnie R. Correll, Heng Gan, Matthias Görges   +7 more
wiley   +1 more source

Shaping the glioblastoma microenvironment to enhance CAR-NK immunotherapy. [PDF]

Front Immunol
Tang E, Chen JY.
europepmc   +1 more source

The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick, Margaretha A. Skowron, Gereon Poschmann, Patrick Petzsch, Ann Kathrin Bergmann, Kai Stühler, Jochen Hecht, Daniel Nettersheim   +7 more
wiley   +1 more source

A Novel MICB-Targeting CAR-NK Cells for the Treatment of Pancreatic Cancer. [PDF]

Int J Mol Sci
Jin W, Wang M, Wang J, Fan J, Fang J, Yang G.   +5 more
europepmc   +1 more source

Can Generative AI support the learning agency of students with disability? A case study of an Australian secondary school

British Journal of Educational Technology, EarlyView.
Abstract Despite increasing interest in using Generative Artificial Intelligence (GenAI) in education, little is known about how students with disability engage with GenAI to support their own learning. This study investigates the potential of ChatGPT to support the learning agency of adolescents with disability in a secondary science classroom in ...
Natasha Anne Rappa, Karen P. Nonis, Kok‐Sing Tang, Grant Cooper, Martin Cooper, Craig Sims   +5 more
wiley   +1 more source

Synergistic immunotherapeutic effects of irreversible electroporation and CAR-NK cell therapy against hepatocellular carcinoma. [PDF]

Signal Transduct Target Ther
Park JD, Shin HE, Jang HJ, Ko S, An YS, Lee JS, Moon S, Seo H, Kim Y, Kim Y, Han JH, Park CG, Kim DH, Park W.   +13 more
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source