Results 41 to 50 of about 45,565 (301)

Thrombin Protease-activated Receptor-1 Signals through Gq- and G13-initiated MAPK Cascades Regulating c-Jun Expression to Induce Cell Transformation [PDF]

, 2003
Although the ability of G protein-coupled receptors to stimulate normal and aberrant cell growth has been intensely investigated, the precise nature of the molecular mechanisms underlying their transforming potential are still not fully understood.
Gutkind, J. Silvio, Marinissen, Maria Julia, Offermanns, Stefan, Servitja, Joan-Marc, Simon, Melvin I.   +4 more
core   +1 more source

Case report: Acute unintentional carbachol intoxication [PDF]

Critical Care, 2006
Abstract Introduction Intoxications with carbachol, a muscarinic cholinergic receptor agonist are rare. We report an interesting case investigating a (near) fatal poisoning. Methods The son of an 84-year-old male discovered a newspaper ...
Schulz, Martin, Graefe, Thomas, Stuby, Klaus, Andresen, Hilke, Kupfermann, Nikolai, Schmoldt, Achim   +5 more
openaire   +5 more sources

The Transition Between Slow-Wave Sleep and REM Sleep Constitutes an Independent Sleep Stage Organized by Cholinergic Mechanisms in the Rostrodorsal Pontine Tegmentum

Frontiers in Neuroscience, 2019
There is little information on either the transition state occurring between slow-wave sleep (SWS) and rapid eye movement (REM) sleep, as well as about its neurobiological bases.
Carlos Carrera-Cañas, Miguel Garzón, Isabel de Andrés   +2 more
doaj   +1 more source

Curcuma longa extract exerts a myorelaxant effect on the ileum and colon in a mouse experimental colitis model, independent of the anti-inflammatory effect. [PDF]

PLoS ONE, 2012
BACKGROUND: Curcuma has long been used as an anti-inflammatory agent in inflammatory bowel disease. Since gastrointestinal motility is impaired in inflammatory states, the aim of this work was to evaluate if Curcuma Longa had any effect on intestinal ...
Rita Aldini, Roberta Budriesi, Giulia Roda, Matteo Micucci, Pierfranco Ioan, Antonia D'Errico-Grigioni, Alessandro Sartini, Elena Guidetti, Margherita Marocchi, Monica Cevenini, Francesca Rosini, Marco Montagnani, Alberto Chiarini, Giuseppe Mazzella   +13 more
doaj   +1 more source

Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol

Brazilian Journal of Medical and Biological Research, 1997
We investigated the effects of losartan, an AT1-receptor blocker, and ramipril, a converting enzyme inhibitor, on the pressor response induced by angiotensin II (ANG II) and carbachol (a cholinergic receptor agonist).
W.A. Saad, A.C. Luiz, L.A.A. Camargo, J.E.N. Silveira, S. Fóglia, J.V. Menani, William A. Saad   +6 more
doaj   +1 more source

TRPV4 Complexes With the Na+/Ca2+ Exchanger and IP3 Receptor 1 to Regulate Local Intracellular Calcium and Tracheal Tension in Mice

Frontiers in Physiology, 2019
Intracellular Ca2+ is critical for regulating airway smooth muscle (ASM) tension. A rapid rise in the intracellular Ca2+ concentration ([Ca2+]i) of ASM cells is crucial for modulating the intensity and length of the ASM contraction.
Jie Zhang, Jie Zhang, Yuan Wei, Suwen Bai, Shenggang Ding, Huiwen Gao, Sheng Yin, Sheng Yin, Shuo Chen, Jinsen Lu, Haoran Wang, Yonggang Shen, Bing Shen, Juan Du   +13 more
doaj   +1 more source

Nutrigenomic insights and cardiovascular benefits of blackberry (Rubus ulmifolius Schott.) and mugwort (Artemisia campestris L.). [PDF]

Exp Physiol
Abstract Blackberry (Rubus ulmifolius Schott) and mugwort (Artemisia campestris L.) are plants traditionally used to treat various pathologies, including hypertension. The vasodilatory and hypotensive effects of blackberry were investigated through experiments in rat models (n = 5 rats per group) and compared with those of mugwort, which had been ...
Mehiou A, Lucau-Danila A, Akissi ZLE, Alla C, Bouanani N, Legssyer A, Hilbert JL, Sahpaz S, Ziyyat A.   +8 more
europepmc   +2 more sources

Local carbachol application induces oral microvascular recruitment and improves gastric tissue oxygenation during hemorrhagic shock in dogs

Frontiers in Immunology
IntroductionHemorrhagic shock is characterized by derangements of the gastrointestinal microcirculation. Topical therapy with nitroglycerine or iloprost improves gastric tissue oxygenation but not regional perfusion, probably due to precapillary ...
Stefan Hof, Lara Lingens, Marius Michels, Carsten Marcus, Anne Kuebart, Anna Herminghaus, Inge Bauer, Olaf Picker, Richard Truse, Christian Vollmer   +9 more
doaj   +1 more source

Diabetes-induced alterations in urothelium function:Enhanced ATP release and nerve-evoked contractions in the streptozotocin rat bladder [PDF]

, 2018
Up to 80% of patients with diabetes mellitus develop lower urinary tract complications, most commonly diabetic bladder dysfunction (DBD). The aim of this study was to investigate the impact of diabetes on the function of the inner bladder lining ...
Apodaca, Birder, Birder, Brown, Chaiyaprasithi, Cheng, Cheng, Cho, Daly, Daneshgari, Daneshgari, Daneshgari, Dunning-Davies, Eika, Ferguson, Fovaeus, Frimodt-Moller, Golbidi, Gomez, Hanna-Mitchell, Hanna-Mitchell, Hawthorn, Kang, Knight, Kolta, Kumar, Kumar, Lai, Langdale, Liu, Liu, Longhurst, Malmgren, Mumtaz, Munoz, Munoz, Mustafa, Nirmal, Pinna, Ren, Sadananda, Sellers, Silva-Ramos, Smith, Stella, Sun, Tammela, Templeman, Vahabi, Vahabi, Vlaskovska, Wang, Xiao, Xiao, Yoshida, Yoshimura, Zhao   +56 more
core   +1 more source

Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels? [PDF]

, 2003
The regulation of ion channels by anionic phospholipids is currently very topical. An outstanding issue is whether phosphatidylinositol 4,5-diphosphate and related species act as true second messengers in signaling or behave in a manner analogous to an ...
Clapp, LH, Cui, Y, Giblin, JP, Quinn, KV, Tinker, A   +4 more
core   +1 more source