Hypervirulence and carbapenem resistance have emerged as two distinct evolutionary directions for Klebsiella pneumoniae, which pose a great threat in clinical settings.
Peng Lan +3 more
doaj +1 more source
Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis [PDF]
Background: Infections due to antibiotic-resistant bacteria are threatening modern health care. However, estimating their incidence, complications, and attributable mortality is challenging.
Abu Sin, Muna +79 more
core +6 more sources
European intensive care physicians’ experience of infections due to antibiotic-resistant bacteria [PDF]
Background Antimicrobial resistance (AMR) compromises the treatment of patients with serious infections in intensive care units (ICUs), and intensive care physicians are increasingly facing patients with bacterial infections with limited or no adequate ...
De Waele, Jan +9 more
core +2 more sources
Antibiotic Resistance Pattern of Multi-drug Resistant Klebsiella pneumoniae and Detection of Carbapenem-resistance Genes [PDF]
Background: Resistance to carbapenem is increasing over the years, which comes as one of the therapy of last resort therapy for critically ill patients. The current scenario is such that the antibiotics in hand are few for carbapenem-resistant Klebsiella
Shreya Shenoy +3 more
doaj
First genomic insights into carbapenem-resistant Klebsiella pneumoniae from Malaysia
Objectives: Despite the increasing reports of carbapenem-resistant Enterobacteriaceae in Malaysia, genomic resources for carbapenem-resistant clinical strains of Klebsiella pneumoniae (K. pneumoniae) remain unavailable.
Han Ming Gan +2 more
doaj +1 more source
The porin and the permeating antibiotic: A selective diffusion barrier in gram-negative bacteria [PDF]
Gram-negative bacteria are responsible for a large proportion of antibiotic resistant bacterial diseases. These bacteria have a complex cell envelope that comprises an outer membrane and an inner membrane that delimit the periplasm.
A Baslé +95 more
core +1 more source
Heteroresistance to Amikacin in Carbapenem-Resistant Klebsiella pneumoniae Strains [PDF]
Heteroresistance can lead to treatment failure and is difficult to detect by the methods currently employed by clinical laboratories. The aim of this study was to investigate the prevalence of the amikacin-heteroresistant Klebsiella pneumoniae strains and explore potential amikacin heteroresistance mechanism through whole-genome sequencing (WGS) and ...
Feiyang Zhang +7 more
openaire +3 more sources
: Objectives: The aims of this study were to investigate the characteristics of Klebsiella pneumoniae meningitis and the impact of convergence of carbapenem resistance and hypervirulence on patient mortality.Methods: Antimicrobial resistance and ...
Yuming Li +6 more
doaj +1 more source
National survey of colistin resistance among carbapenemase-producing Enterobacteriaceae and outbreak caused by colistin-resistant OXA-48-producing Klebsiella pneumoniae, France, 2014 [PDF]
From January 2014 to December 2014, 972 consecutive non-replicate carbapenemase-producing Enterobacteriaceae isolates from colonised or infected patients were collected at the Associated French National Reference Centre as part of the French national ...
Dortet, L +3 more
core +1 more source
Background: Bacteraemia due to carbapenem-resistant gram-negative bacteria is challenging. This study examined the burden of carbapenem and colistin resistance in Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii bacteraemia in ...
A. Balkhair +7 more
doaj +1 more source

