Results 41 to 50 of about 25,641 (181)

Clinical Epidemiology, Risk Factors, and Control Strategies of Klebsiella pneumoniae Infection

Frontiers in Microbiology, 2021
Klebsiella species cause infections at multiple sites, including lung, urinary tract, bloodstream, wound or surgical site, and brain. These infections are more likely to occur in people with preexisting health conditions.
De Chang, De Chang, Lokesh Sharma, Charles S. Dela Cruz, Dong Zhang, Dong Zhang   +5 more
doaj   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae [PDF]

The Lancet Infectious Diseases, 2018
Pengcheng, Du, Yuanyuan, Zhang, Chen, Chen   +2 more
  +9 more sources

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Prevalence of Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae and Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae in China Determined via Mouse Lethality Tests

Frontiers in Cellular and Infection Microbiology, 2022
ObjectiveTo investigate the epidemiology of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKP) and hypervirulent carbapenem-resistant Klebsiella pneumoniae (Hv-CRKP).MethodsTotally 436 K. pneumoniae strains were collected from 7 hospitals in mainland China between 2017.01 and 2018.02.
Dakang Hu, Wenjie Chen, Qi Zhang, Meng Li, Zehua Yang, Yong Wang, Yunkun Huang, Gang Li, Dongxing Tian, Pan Fu, Pan Fu, Weiwen Wang, Ping Ren, Qing Mu, Lianhua Yu, Xiaofei Jiang   +15 more
openaire   +3 more sources

Outcome of carbapenem or colistin resistant Klebsiella pneumoniae bacteremia in the intensive care unit

Scientific Reports
Carbapenem-resistant Klebsiella pneumoniae (CRKp) infections continue to be an important cause of mortality. In this retrospective study, the effect of carbapenem or colistin resistance on mortality in Klebsiella pneumoniae bacteremia and combined ...
Cihan Semet, Kadir Efe, Halis Akalın, Remzi İşçimen, Nermin Kelebek Girgin, Cüneyt Özakın, Naci Cangül, Ferda Kahveci   +7 more
doaj   +1 more source

Prevalence and Impact on Mortality of Colonization and Super-Infection by Carbapenem-Resistant Gram-Negative Organisms in COVID-19 Hospitalized Patients

Viruses, 2023
Background: The relationship between superinfection by multidrug-resistant Gram-negative bacteria and mortality among SARS-CoV-2 hospitalized patients is still unclear.
Roberto Casale, Gabriele Bianco, Paulo Bastos, Sara Comini, Silvia Corcione, Matteo Boattini, Rossana Cavallo, Francesco Giuseppe De Rosa, Cristina Costa   +8 more
doaj   +1 more source

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Risk Factors for Subsequential Carbapenem-Resistant Klebsiella pneumoniae Clinical Infection Among Rectal Carriers with Carbapenem-Resistant Klebsiella pneumoniae.

Infection and drug resistance, 2020
Carbapenem-resistant Klebsiella pneumoniae (CRKP) infection has become a critical clinical concern for its high mortality. Rectal carriage of CRKP has been reported playing an important role in CRKP infection; however, the extent to which carrier develops clinical CRKP infection is unclear.
Chen,Xia, Liu,Qingnuan, Liu,Wen-en, Yan,Qun   +3 more
openaire   +4 more sources

Disinfection Strategies of Carbapenem-resistant Klebsiella Pneumoniae in a Healthcare Facility

Antibiotics, 2022
Abstract Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) infections have become a major global public health challenge. Disinfectants play an important role in controlling horizontal transmission in healthcare facilities. However, the long and extensive routine use of disinfectants, and far less regulated, leading to concern about
Lijia Ni, Zhixian Zhang, Rui Shen, Xiaoqiang Liu, Xuexue Li, Baiji Chen, Xiquan Wu, Hongyu Li, Xiaoying Xie, Songyin Huang   +9 more
openaire   +3 more sources