Results 51 to 60 of about 19,967 (214)

Prevalence of Carbapenemases in Carbapenem-Resistant Acinetobacter baumannii Isolates from the Kingdom of Bahrain

Antibiotics, 2023
Background: Acinetobacter baumannii is regarded as a significant cause of death in hospitals. The WHO recently added carbapenem-resistant Acinetobacter baumannii (CRAB) to its global pathogen priority list.
Nouf Al-Rashed, Khalid M. Bindayna, Mohammad Shahid, Nermin Kamal Saeed, Abdullah Darwish, Ronni Mol Joji, Ali Al-Mahmeed   +6 more
doaj   +1 more source

Novel nanoparticle‐mediated plasmid delivery in bacteria for difficult applications

Journal of Chemical Technology &Biotechnology, Volume 101, Issue 1, Page 123-134, January 2026.
Abstract BACKGROUND This study presents the development and application of magnetite/silver‐pDMAEMA‐PEG‐BUFII nanobioconjugates as an advanced plasmid delivery system in bacteria. These nanobioconjugates demonstrated superior efficiency compared to traditional methods in four challenging applications: (i) genomic editing in Gram‐positive bacteria; (ii)
Laura D. Páez‐Angarita, Laura X. Henao, Sebastián Jaramillo‐Toro, Valentina Quezada, Silvia Restrepo, Juan C. Cruz, Johana Husserl   +6 more
wiley   +1 more source

Detection of rare carbapenemases in Enterobacterales—comparison of two colorimetric and three CIM-based carbapenemase assays

Microbiology Spectrum
Rapid and reliable detection of carbapenemase-producing Enterobacterales (CPE) is crucial for prompt treatment and infection control. Most assays target the primary four enzymes (KPC, OXA-48-like, VIM, and NDM), often missing less common variants (e.g ...
Lukas Schaffarczyk, Janina Noster, Yvonne Stelzer, Janko Sattler, Sören Gatermann, Axel Hamprecht   +5 more
doaj   +1 more source

Cefiderocol against Multi-Drug and Extensively Drug-Resistant Escherichia coli: An In Vitro Study in Poland

Pathogens, 2022
Cefiderocol (CFDC) is a novel, broad-spectrum siderophore cephalosporin with potential activity against multi-drug (MDR) and extensively drug-resistant (XDR) Enterobacterales, including carbapenem-resistant strains.
Patrycja Zalas-Więcek, Katarzyna Płachta, Eugenia Gospodarek-Komkowska   +2 more
doaj   +1 more source

Carbapenemase-producing Enterobacteriaceae in transplant patients

Journal of Antimicrobial Chemotherapy, 2021
Abstract Carbapenemase-producing Enterobacteriaceae (CPE) are a serious public health concern and represent a major threat to immunocompromised hosts, including solid organ (SOT) and stem cell transplant (HSCT) recipients. Transplant patients are at particular risk of developing CPE colonization and/or infection due to their frequent ...
Giannella M., Bartoletti M., Conti M., Righi E.   +3 more
openaire   +3 more sources

Population Pharmacokinetic and Pharmacodynamic Prediction for Tebipenem Pivoxil Treatment of Pediatric Shigellosis

Clinical and Translational Science, Volume 19, Issue 1, January 2026.
ABSTRACT Increasing antimicrobial resistance poses a serious challenge for the treatment of Shigella infections, and there is an urgent need for alternative antibacterial treatments. We conducted a clinical trial to investigate the efficacy of oral tebipenem pivoxil, compared to intravenous ceftriaxone, in Bangladeshi children with shigellosis.
Cindy X. Zhang, Sharika Nuzhat, Md Ridwan Islam, Syed Jayedul Bashar, Subhasish Das, Rukaeya Amin, Firdausi Qadri, Farhana Khanam, Dilruba Ahmed, Patricia B. Pavlinac, Mohammod Jobayer Chisti, Tahmeed Ahmed, Samuel L. M. Arnold   +12 more
wiley   +1 more source

Epidemiological and clinical characteristics of patients with carbapenem-resistant Enterobacterales in a university hospital of Colombia: Enzyme coproductions in rise

Heliyon
The distribution of carbapenemases in Carbapenem-Resistant Enterobacterales (CRE) has recently undergone a change in our region. According to the Colombian National Institute of Health, there is an increasing prevalence of NDM and NDM-KPC co-producing ...
Juan Fernando Contreras-Valero, Sandra Milena Gualtero-Trujillo, Gloria Cecilia Cortés-Fraile, Sebastián Hernández-Garzón, Natalia Manrique-Marín, Miguel Ángel Narváez-Chaves, Sandra Liliana Valderrama-Beltrán   +6 more
doaj   +1 more source

Genetic Diversity of Polymyxin Resistance Genes in Klebsiella pneumoniae Clinical Isolates

Molecular Ecology, Volume 35, Issue 2, January 2026.
ABSTRACT This study investigates the genetic diversity and evolutionary mechanisms driving polymyxin resistance in Klebsiella pneumoniae, a critical priority pathogen. By analysing mgrB, phoPQ and pmrAB genes in susceptible (PM‐S) and resistant (PM‐R) populations through neutrality tests (Tajima D, Fu & Li's D) we uncovered polygenic adaptation and ...
Daniel Miceli Serwy, Maria Eduarda Rocha Conde, Ana Luiza Carneiro Alencar, Roberto Leonan Morim Novaes, Josué da Costa Lima‐Junior, Fabio Faria da Mota, Ana Paula Carvalho‐Assef, Teca Calcagno Galvao, Viviane Zahner   +8 more
wiley   +1 more source

Comparative analysis of selected methods of carbapenemase determination among clinical Klebsiella pneumoniae.

PLoS ONE
Klebsiella pneumoniae is a typical opportunistic pathogen that exhibits multiple virulence factors and antibiotic resistance conditioning mechanisms. Carbapenemases are enzymes that help bacteria to exhibit the strongest resistance against antibiotics ...
Agata Pruss, Alicja Skierska, Paweł Kwiatkowski, Helena Masiuk, Joanna Jursa-Kulesza, Stefania Giedrys-Kalemba, Iwona Bilska, Monika Sienkiewicz, Maria V Melnyk, Barbara Dołęgowska   +9 more
doaj   +1 more source

Rapidly spreading Enterobacterales with OXA-48-like carbapenemases

Journal of Clinical Microbiology
Enterobacterales (mostly Klebsiella pneumoniae, Escherichia coli) with OXA-48-like carbapenemases (e.g., OXA-48, -181, -232, -244) are undermining the global efficiency of carbapenem therapy. In the Middle East, North Africa, and some European countries,
Gisele Peirano, Johann D. D. Pitout
doaj   +1 more source