Results 61 to 70 of about 43,420 (302)

Identification and screening of carbapenemase-producing Enterobacteriaceae [PDF]

Clinical Microbiology and Infection, 2012
Carbapenem-hydrolysing β-lactamases are the most powerful β-lactamases, being able to hydrolyse almost all β-lactams. They are mostly of the KPC, VIM, IMP, NDM and OXA-48 types. Their current extensive spread worldwide in Enterobacteriaceae is an important source of concern, as these carbapenemase producers are multidrug-resistant.
Patrice Nordmann, Marek Gniadkowski, Christian G. Giske, Laurent Poirel, Neil Woodford, Vivì Miriagou   +5 more
openalex   +4 more sources

Novel Rapid Test for Detecting Carbapenemase [PDF]

Emerging Infectious Diseases, 2020
We developed a carbapenemase test based on the ability of imipenem to inhibit noncarbapenemase β-lactamases. The test uses bacterial isolates with a fluorescent β-lactamase substrate, producing objective results with 100% sensitivity and specificity in 10 minutes. The assay is inexpensive and consists of only 1 mixing step.
Michael Pigula, Akilan Palanisami, Shoaib Ashraf, Tayyaba Hasan, Jerrin Kuriakose, Yanfang Feng   +5 more
openaire   +4 more sources

Comparison of Molecular and Phenotypic Methods for the Detection and Characterization of Carbapenem Resistant Enterobacteriaceae [PDF]

, 2016
In recent years, there has been a rapid dissemination of carbapenem resistant Enterobacteriaceae (CRE). This study aimed to compare phenotypic and molecular methods for detection and characterization of CRE isolates at a large tertiary care hospital in ...
Absar, Muhammad M., Abukhalid, Norah, Garaween, Ghada A., Senok, Abiola C., Somily, Ali M.   +4 more
core   +1 more source

Activity of imipenem/relebactam against Pseudomonas aeruginosa producing ESBLs and carbapenemases.

Journal of Antimicrobial Chemotherapy, 2020
BACKGROUND ESBL- and carbapenemase-producing Pseudomonas aeruginosa are prevalent in, for example, the Middle East, Eastern Europe and Latin America, though rarer elsewhere. Because P.
S. Mushtaq, D. Meunier, A. Vickers, N. Woodford, D. Livermore   +4 more
semanticscholar   +1 more source

Carbapenemases

, 2019
Carbapenems are usually regarded as the last treatment option for serious infections caused by Gram-negative and Gram-positive microorganisms. Although they are stable to hydrolysis by most β- lactamases, their usage as the last resort antbiotics was seriously compromised by the appearance of carbapenem-hydrolyzing enzymes called carbapenemases.
Bedenić, Branka, Sardelić, Sanda
openaire   +2 more sources

Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA) [PDF]

, 2016
Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients.
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core   +4 more sources

Carbapenemase-producing Enterobacteriaceae in transplant patients

Journal of Antimicrobial Chemotherapy, 2021
Abstract Carbapenemase-producing Enterobacteriaceae (CPE) are a serious public health concern and represent a major threat to immunocompromised hosts, including solid organ (SOT) and stem cell transplant (HSCT) recipients. Transplant patients are at particular risk of developing CPE colonization and/or infection due to their frequent ...
Giannella M., Bartoletti M., Conti M., Righi E.   +3 more
openaire   +4 more sources

Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii from Southern Brazil

Revista de Epidemiologia e Controle de Infecção, 2021
Carbapenem resistance in Acinetobacter baumannii has reached extremely high levels worldwide and class D OXA-type carbapenemases are the main associated mechanism.
Gabriel de Paula Gollino, Bruna Machado Escobar, Ilson Dias da Silveira, Rosa Helena Robales Siqueira, Joseane Cristina Ferreira, Ana Lúcia da Costa Darini, Vanessa Bley Ribeiro   +6 more
doaj   +1 more source

Overview of Carbapenemase mediated resistance [PDF]

International Journal of Infectious Diseases, 2012
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openaire   +3 more sources

Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014. [PDF]

, 2016
In 2014, a total of 2,976 Enterobacteriaceae isolates with decreased susceptibility to carbapenems were received at the French Associated National Reference Center for Antibiotic Resistance (NRC) and were characterised for their molecular resistance ...
Cuzon, G., Dortet, L., Nordmann, P., Ponties, V.   +3 more
core   +1 more source