Results 201 to 210 of about 134,116 (237)

Carbohydrate-active enzymes (CAZymes) in the gut microbiome

Nature Reviews Microbiology, 2022
The 1013-1014 microorganisms present in the human gut (collectively known as the human gut microbiota) dedicate substantial percentages of their genomes to the degradation and uptake of carbohydrates, indicating the importance of this class of molecules.
Stephen Withers, Jacob F Wardman, Peter Rahfeld   +2 more
exaly   +3 more sources

Role of carbohydrate-active enzymes in mycorrhizal symbioses

Essays in Biochemistry, 2023
Abstract Mycorrhizal fungi form mutually beneficial interactions with a wide range of terrestrial plants. During this symbiosis, the associated fungus provides mineral nutrients, such as phosphorus and nitrogen, to its host plant in exchange of photosynthesis-derived carbohydrates.
Gong, Yuhua, Lebreton, Annie, Zhang, Feng, Martin, Francis   +3 more
openaire   +4 more sources

Enzyme promiscuity of carbohydrate active enzymes and their applications in biocatalysis

Current Opinion in Structural Biology, 2020
The application of biocatalysis for the synthesis of glycans and glycoconjugates is a well-established and successful strategy, both for small and large scale synthesis. Compared to chemical synthesis, is has the advantage of high selectivity, but biocatalysis had been largely limited to natural glycans both in terms of reactivity and substrates.
Edward, Pallister, Christopher J, Gray, Sabine L, Flitsch   +2 more
openaire   +2 more sources

Advances in the understanding and exploitation of carbohydrate-active enzymes

Current Opinion in Chemical Biology
Carbohydrate-active enzymes (CAZymes) are responsible for the biosynthesis, modification and degradation of all glycans in Nature. Advances in genomic and metagenomic methodologies, in conjunction with lower cost gene synthesis, have provided access to a steady stream of new CAZymes with both well-established and novel mechanisms.
Stephen Withers, Jacob F Wardman, Seyed A Nasseri   +2 more
exaly   +3 more sources

Carbohydrate-active enzymes

Sarah A. Allman
exaly   +3 more sources

Polymeric Iminosugars Improve the Activity of Carbohydrate-Processing Enzymes

Bioconjugate Chemistry, 2015
Multivalent iminosugars have recently emerged as powerful tools to inhibit the activities of specific glycosidases. In this work, biocompatible dextrans were coated with iminosugars to form linear and ramified polymers with unprecedently high valencies (from 20 to 900) to probe the evolution of the multivalent inhibition as a function of ligand valency.
Brissonnet, Yoan, Ladeveze, Simon, Teze, David, Fabre, Emeline, Deniaud, David, Daligault, Franck, Tellier, Charles, Sesták, Sergej, Remaud Simeon, Magali, Potocki-Veronese, Gabrielle, Gouin, Sébastien G   +10 more
openaire   +4 more sources

Interaction of carbohydrates with alcohol dehydrogenase: Effect on enzyme activity

Journal of Bioscience and Bioengineering, 2015
Alcohol dehydrogenase was covalently conjugated with three different oxidized carbohydrates i.e., glucose, starch and pectin. All the carbohydrates inhibited the enzyme. The inhibition was studied with respect to the inhibition rate constant, involvement of thiol groups in the binding, and structural changes in the enzyme. The enzyme activity decreased
Jadhav, Swati B., Bankar, Sandip B., Granström, Tom, Ojamo, Heikki, Singhal, Rekha S., Survase, Shrikant, A.   +6 more
openaire   +2 more sources

Electrostatic studies of carbohydrate active enzymes

1995
Abstract Most charged or titratable residues reside on the protein surface. Each of such residues will exhibit a titration behaviour that is dependent on the local context around the residue. As a consequence both pH, salt and docking of a ligand into the binding cavity of a protein can be expected to alter the protein electrostatics.
Antonio Baptista, Trygve Brautaset, Finn Drabløs, Paulo Martel, Svein Valla, Steffen B. Petersen   +5 more
openaire   +1 more source

Carbohydrate-active enzymes: sequences, shapes, contortions and cells

Biochemical Society Transactions, 2016
The enzyme-catalysed degradation of oligo and polysaccharides is of considerable interest in many fields ranging from the fundamental–understanding the intrinsic chemical beauty–through to the applied, including diverse practical applications in medicine and biotechnology.
Gideon J, Davies, Spencer J, Williams
openaire   +2 more sources

A census of carbohydrate-active enzymes in the genome of Arabidopsis thaliana

Plant Molecular Biology, 2001
The synthesis, modification, and breakdown of carbohydrates is one of the most fundamentally important reactions in nature. The structural and functional diversity of glycosides is mirrored by a vast array of enzymes involved in their synthesis (glycosyltransferases), modification (carbohydrate esterases) and breakdown (glycoside hydrolases and ...
B, Henrissat, P M, Coutinho, G J, Davies
openaire   +2 more sources