An Unusual Carbohydrate Conformation is Evident in Moraxella catarrhalis Oligosaccharides [PDF]
Molecules, 2015 Oligosaccharide structures derived from the lipooligosaccharide of M. catarrhalis show that the highly branched glucose-rich inner core of the oligosaccharide has an altered conformation compared to the most truncated tetra-glucose-Kdo lgt1/4Δ ...
Martin Frank +4 more
doaj +7 more sources
Shape: automatic conformation prediction of carbohydrates using a genetic algorithm [PDF]
Journal of Cheminformatics, 2009 Background Detailed experimental three dimensional structures of carbohydrates are often difficult to acquire. Molecular modelling and computational conformation prediction are therefore commonly used tools for three dimensional structure studies ...
Rosen Jimmy +2 more
doaj +5 more sources
Molecular architecture with carbohydrate functionalized β-peptides adopting 314-helical conformation [PDF]
Beilstein Journal of Organic Chemistry, 2014 Carbohydrate recognition is essential in cellular interactions and biological processes. It is characterized by structural diversity, multivalency and cooperative effects.
Nitin J. Pawar +4 more
doaj +2 more sources
Human coronavirus HKU1 spike structures reveal the basis for sialoglycan specificity and carbohydrate-promoted conformational changes [PDF]
Nature CommunicationsThe human coronavirus HKU1 uses both sialoglycoconjugates and the protein transmembrane serine protease 2 (TMPRSS2) as receptors. Carbohydrate binding leads to the spike protein up conformation required for TMPRSS2 binding, an outcome suggesting a ...
Min Jin +11 more
doaj +2 more sources
Bivalent Inhibitors of Mannose-Specific Bacterial Adhesion: A Xylose-Based Conformational Switch to Control Glycoligand Distance [PDF]
MoleculesFunctional glycomimetics is suited to study the parameters of carbohydrate recognition that forms the basis of glycobiology. It is particularly attractive when a glycoligand allows for the investigation of two different states, such as varying distance ...
Sven Ole Jaeschke +2 more
doaj +2 more sources
Solvent interactions determine carbohydrate conformation [PDF]
Proceedings of the National Academy of Sciences, 2001 The relationship between the three-dimensional structures of oligosaccharides and polysaccharides and their biological properties has been the focus of many recent studies. The overall conformation of an oligosaccharide depends primarily on the orientation of the torsion angles (φ, ψ, and ω) between glycosyl residues. Numerous experimental
Karl N. Kirschner, Robert J. Woods
openalex +3 more sources
Targeting galectin-3 in cancer by novel and unique inhibitors of non-carbohydrate origin [PDF]
Molecular MedicineThe galactoside-binding galectin-3 is a multi-mode promoter in a broad range of cancers, as well as in the pathogenesis of inflammation and fibrosis-associated diseases. It is currently a hotly pursued therapeutic target in those disease areas.
Paulina Sindrewicz-Goral +8 more
doaj +2 more sources
Carbohydrate- and Conformation-dependent Cargo Capture for ER-Exit [PDF]
Molecular Biology of the Cell, 2005 Some secretory proteins leave the endoplasmic reticulum (ER) by a receptor-mediated cargo capture mechanism, but the signals required for the cargo-receptor interaction are largely unknown. Here, we describe a novel targeting motif that is composed of a high-mannose type oligosaccharide intimately associated with a surface-exposed peptide β-hairpin ...
Christian Appenzeller‐Herzog +5 more
openalex +5 more sources
Carbohydrate conformation and lipid condensation in monolayers containing glycosphingolipid Gb3: influence of acyl chain structure. [PDF]
Biophys J, 2014 Watkins EB +7 more
europepmc +2 more sources
Conformational studies on the N‐linked carbohydrate chain of bromelain [PDF]
European Journal of Biochemistry, 1990 1H‐ and 13C‐NMR assignments for the carbohydrate part of the glycopeptide α‐d‐Man‐(1→6)‐[ß‐d‐Xyl‐(1→2)]‐ß‐d‐Man‐(1→4)‐ß‐d‐GlcNAc‐(1→4)‐[α‐l‐Fuc‐(1→3)]‐ß‐d‐ GlcNAc‐(1→N)‐Asn∼, derived from the proteolytic enzyme bromelain (EC 3.4.22.4), have been obtained using homo‐ and heteronuclear correlation spectroscopy, two‐dimensional homonuclear Hartmann‐Hahn ...
Jan B. Bouwstra +5 more
openalex +5 more sources