An Unusual Carbohydrate Conformation is Evident in Moraxella catarrhalis Oligosaccharides [PDF]
Molecules, 2015 Oligosaccharide structures derived from the lipooligosaccharide of M. catarrhalis show that the highly branched glucose-rich inner core of the oligosaccharide has an altered conformation compared to the most truncated tetra-glucose-Kdo lgt1/4Δ ...
Martin Frank +4 more
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Solvent interactions determine carbohydrate conformation [PDF]
Proceedings of the National Academy of Sciences, 2001 The relationship between the three-dimensional structures of oligosaccharides and polysaccharides and their biological properties has been the focus of many recent studies. The overall conformation of an oligosaccharide depends primarily on the orientation of the torsion angles (φ, ψ, and ω) between glycosyl residues. Numerous experimental
Karl N. Kirschner, Robert J. Woods
semanticscholar +5 more sources
Carbohydrate Self‐Assembly at Surfaces: STM Imaging of Sucrose Conformation and Ordering on Cu(100) [PDF]
Angewandte Chemie, 2019 Saccharides are ubiquitous biomolecules, but little is known about their interaction with, and assembly at, surfaces. By combining preparative mass spectrometry with scanning tunneling microscopy, we have been able to address the conformation and self ...
Sabine Abb +7 more
semanticscholar +4 more sources
Gene-Silencing-Induced Changes in Carbohydrate Conformation in Relation to Bioenergy Value and Carbohydrate Subfractions in Modeled Plant (Medicago sativa) with Down-Regulation of HB12 and TT8 Transcription Factors. [PDF]
Int J Mol Sci, 2016 Gene silencing with RNA interference (RNAi) technology may be capable of modifying internal structure at a molecular level. This structural modification could affect biofunctions in terms of biodegradation, biochemical metabolism, and bioactive compound ...
Li X, Hannoufa A, Zhang Y, Yu P.
europepmc +2 more sources
Influence of Trp flipping on carbohydrate binding in lectins. An example on Aleuria aurantia lectin AAL. [PDF]
PLoS ONE, 2017 Protein-carbohydrate interactions are very often mediated by the stacking CH-π interactions involving the side chains of aromatic amino acids such as tryptophan (Trp), tyrosine (Tyr) or phenylalanine (Phe).
Josef Houser +6 more
doaj +2 more sources
Human coronavirus HKU1 spike structures reveal the basis for sialoglycan specificity and carbohydrate-promoted conformational changes [PDF]
Nature CommunicationsThe human coronavirus HKU1 uses both sialoglycoconjugates and the protein transmembrane serine protease 2 (TMPRSS2) as receptors. Carbohydrate binding leads to the spike protein up conformation required for TMPRSS2 binding, an outcome suggesting a ...
Min Jin +11 more
doaj +2 more sources
Bivalent Inhibitors of Mannose-Specific Bacterial Adhesion: A Xylose-Based Conformational Switch to Control Glycoligand Distance [PDF]
MoleculesFunctional glycomimetics is suited to study the parameters of carbohydrate recognition that forms the basis of glycobiology. It is particularly attractive when a glycoligand allows for the investigation of two different states, such as varying distance ...
Sven Ole Jaeschke +2 more
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Carbohydrate conformation and lipid condensation in monolayers containing glycosphingolipid Gb3: influence of acyl chain structure. [PDF]
Biophys J, 2014 Watkins EB +7 more
europepmc +2 more sources
Targeting galectin-3 in cancer by novel and unique inhibitors of non-carbohydrate origin [PDF]
Molecular MedicineThe galactoside-binding galectin-3 is a multi-mode promoter in a broad range of cancers, as well as in the pathogenesis of inflammation and fibrosis-associated diseases. It is currently a hotly pursued therapeutic target in those disease areas.
Paulina Sindrewicz-Goral +8 more
doaj +2 more sources
Framework-mediated binding of foreign and self-glycans by IGHV4–34 antibodies [PDF]
Frontiers in ImmunologyCold agglutinin disease is an autoimmune condition characterised by expression of self-reactive antibodies to I/i carbohydrate blood group antigens (polymers of N-acetyllactosamine or ‘LacNAc’ units) resulting in anaemia through the agglutination and ...
David B. Langley +9 more
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