Results 111 to 120 of about 11,416 (241)

TRMT61A‐Mediated m1A Modification Suppresses FDX1 Translation to Drive Cuproptosis Evasion and Radioresistance in Hepatocellular Carcinoma

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This study identifies tRNA methyltransferase 61 A (TRMT61A)‐mediated N1‐methyladenosine (m1A) modification as a driver of radioresistance in hepatocellular carcinoma (HCC) by suppressing cuproptosis. TRMT61A methylates FDX1 mRNA, enabling YTHDF3 recognition and eRF1 recruitment to inhibit FDX1 translation.
Yunyun Xiao, Yue Li, Zelei Li, Rui Wang, Dongni Shi, Yanling Wen, Yibing Pan, Chen Lin, Junguo Bu, Libing Song, Hui Dai   +10 more
wiley   +1 more source

Comprehensive Investigation of Benzimidazolium Derivatives Through Synthesis, Characterization, Cytotoxicity Activity, Immunocytochemistry, and ADME and Toxicity Analyses

ChemistryOpen, Volume 15, Issue 9, September 2026.
Three benzimidazolium derivatives bearing fluoro, chloro, and methoxy substituents are synthesized and evaluated for anticancer activity. Compound 2b shows the highest antiproliferative activity and induces apoptosis through caspase‐3 activation and PARP1 cleavage. In this study, three novel benzimidazolium derivatives (2a–c) bearing 4‐fluoro, 3‐chloro,
Gulay Dilek, Senem Akkoc
wiley   +1 more source

Lipodystrophy and adipose tissue recovery are mediated by the Wnt/lipogenesis axis during skin fibrosis

The Journal of Pathology, Volume 270, Issue 1, Page 98-113, September 2026.
Abstract Acquired lipodystrophy in the dermal white adipose tissue (DWAT) is an early phenotype of skin fibrosis, followed by the accumulation of extracellular matrix (ECM). Lipodystrophy syndromes are estimated to affect 1 in 20,000 people and are associated with metabolic comorbidities.
Suneeti R Madhavan, Piper Moore, Rohan Varshney, Miles Montegut, Qiannan Ma, Kayla Klatt, Reshmi Parameswaran, Elif G Ertugral, Chandrasekhar R Kothapalli, Michael C Rudolph, Radhika P Atit   +10 more
wiley   +1 more source

A cryptic allosteric pocket shapes isoform‐selective inhibition of human malic enzymes

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Malic enzymes (ME) regulate central carbon metabolism and cellular redox balance, and the mitochondrial isoform ME2 is frequently upregulated in aggressive cancers to support metabolic flexibility and stress resistance. Isoform‐selective inhibition has remained out of reach because the catalytic machinery is essentially invariant across the ...
Ben A. Krinkel, Yuliana Yosaatmadja, Mark D. Slayton, Anita Krinkel, Jack Copping, Jin Heon Jeon, Joyce Eu, Kerslee Kohagen, Amir Ashoorzadeh, Jeff Smaill, Jack Flanagan, Christopher Walker, Sofia D. Merajver, Kerry Loomes, Christopher J. Squire   +14 more
wiley   +1 more source

Review of The Physics and Technology of Radiation Therapy, 3rd ed., by McDermott and Orton

Journal of Applied Clinical Medical Physics, Volume 27, Issue 9, September 2026.
Megan A. Hyun
wiley   +1 more source

From fossil to bio‐circular plastics: the environmental benefits of bio‐attributed acrylonitrile butadiene styrene in single‐use cystoscopes

BJU International, Volume 138, Issue 3, Page 480-490, September 2026.
Background Single‐use cystoscopes are increasingly adopted in urology, but concerns regarding their environmental footprint persist. Substituting conventional fossil‐based plastics with bio‐attributed materials may reduce life cycle impacts, yet the magnitude and robustness of this benefit remain uncertain.
Arthur Peyrottes, Thibaut Long Depaquit, Maxime Pattou, Elliot Tokarski, Alessandro Uleri, Richard Mallet, Michael Baboudjian   +6 more
wiley   +1 more source

Designing Polymer Nanocomposites for X‐Ray Shielding: Mechanisms, Architectures, and Scalable Processing

Advanced Engineering Materials, Volume 28, Issue 15, 5 August 2026.
This review highlights advances in lightweight, lead‐free polymer nanocomposites for diagnostic X‐ray shielding. By linking filler chemistry, dispersion, architecture, and photon interaction mechanisms, it establishes structure–performance relationships guiding material design.
Aklilu G. Messele, Hossein Ipakchi, Tizazu H. Mekonnen   +2 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, Volume 20, Issue 8, Page 1913-1932, August 2026.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Systematic review of physical and dosimetric criteria for managing CIEDs in radiotherapy: A medical physicist's perspective

Journal of Applied Clinical Medical Physics, Volume 27, Issue 8, August 2026.
Abstract Aim Current radiotherapy (RT) guidelines for Cardiac Implantable Electronic Devices (CIEDs) are largely based on clinical management strategies and retrospective reports. This systematic review adopts a medical physics perspective to provide a critical, quantitative analysis of the technical evidence required for developing robust safety ...
Tiziana Malatesta, Agnese Barbareschi, Rita Alaimo, Emilio Mezzenga, Maria Grazia Brambilla, Anna Delana, Stefano Andreoli, Rita Consorti, Stefano Ren Kaiser, Marco Mapelli, Eugenia Moretti, Maria Mormile, Giulia Rambaldi Guidasci, Mara Severgnini, Lidia Strigari, Maria Daniela Falco   +15 more
wiley   +1 more source

Nanoplatforms for Sentinel and Tumor‐Draining Lymph Node Mapping: From Visualization to Pathway‐Informed Staging

Advanced Healthcare Materials, Volume 15, Issue 30, 14 August 2026.
Lymphotropic nanoplatforms integrate multimodal imaging with therapeutic guidance to map sentinel and tumor‐draining lymph nodes, revealing functional drainage, metastatic involvement, and nodal accessibility, while providing mechanistic insight to support precision surgical and therapeutic interventions.
Xu Chen, Nina Li, Meiyan Zou, Zihao Zhou, Rongwei Xu, Weiyao Feng, Xinyuan Zhao, Li Cui   +7 more
wiley   +1 more source