Results 151 to 160 of about 3,400,910 (254)

Protein Lactylation in Cancer: From Mechanisms to Therapy

MedComm, Volume 7, Issue 11, November 2026.
Increased glycolysis and lactate accumulation promote histone and nonhistone protein lactylation, linking tumor metabolic reprogramming to treatment adaptation. Lactylation enhances DNA repair, suppresses antitumor immunity, strengthens antioxidant defenses, and facilitates cell‐cycle checkpoint escape, collectively promoting resistance to chemotherapy,
Wentian Huang, Ping Hu, Shun Wang, Xide Zhang, Ziran Ye, Shengqiang Chen, Fu Gao, Yuanyuan Chen, Yanyong Yang   +8 more
wiley   +1 more source

Carbon ion radiotherapy in NIRS

Carbon ion radiotherapy in NIRS
High linear energy transfer (LET) charged particle therapy with carbon ions has been of interest in the treatment of malignant tumors because of better dose localization in the tumor volume and greater biologic effectiveness. In 1984, the Heavy Ion Medical Accelerator in Chiba (HIMAC) was constructed at the National Institute of Radiological Sciences ...
openaire   +1 more source

Engineering Safety Through MOFs‐Based Nanocomposites: Advances in Design, Fabrication, and Deployment Across Emerging Domains

Rare Metals, Volume 45, Issue 11, November 2026.
ABSTRACT Ensuring uncompromised safety across interconnected domains is vital for global societal sustainability. Metal–organic framework (MOF)‐based nanocomposites, owing to their intrinsically tunable structures and broad functional versatility, represent a powerful class of materials for safety‐related engineering.
Rongfu Peng, Chong Chen, Hao Yang, Quan Lou, Yiju Tang, Dongwei Zhu, Chengzhang Zhu   +6 more
wiley   +1 more source

Review on heavy ion radiotherapy facilities and related ion sources

Heavy ion radiotherapy awakens worldwide interest recently. The clinical results obtained by the Heavy Ion Medical Accelerator in Chiba at the National Institute of Radiological Sciences in Japan have clearly demonstrated the advantages of carbon ion ...
455553, 455552, 455551, 455550, Ａｒｎｅ Ｄｒｅｎｔｊｅ, Drentje, Arne, 村松 正幸, 藤田 敬, Kitagawa, Atsushi, 北川 敦志, Muramatsu, Masayuki, Ｓａｎｄｏｒ Ｂｉｒｉ, Fujita, Takashi, 455549, 455548, 455547, 455546, 455545, Biri, Sandor, 455554   +19 more
core  

Carbon Ion Radiotherapy for Malignant Head-and-Neck ｔumors

Carbon ion radiotherapy, with its powerful biological effects, provides excellent therapeutic efficacy for patients with radioresistant tumors. By focusing the irradiation beam on the target lesion, this approach guarantees a low probability of damage to
Ikawa, Hiroaki, 555881, 555882, 555883, 555884, Koto, Masashi, 伊川 裕明, 鎌田 正, 555880, 555878, Tsujii, Hirohiko, 555879, Kamada, Tadashi, 555885, 555875, 555886, 555876, 長谷川, 安都佐, 555877, 高木 亮, 長谷川 安都佐, 小藤 昌志, Takagi, Ryo, 辻井 博彦   +23 more
core  

Carbon ion radiotherapy at NIRS

Carbon ion radiotherapy at NIRS
In 1994, carbon ion radiotherapy was begun at the National Institute of Radiological Sciences using the Heavy Ion Medical Accelerator in Chiba, which was the worlds 􀂿rst heavy ion accelerator complex dedicated to medical use in a hospital environment. Among several types of ion species, carbon ions were selected for cancer therapy because they
openaire   +1 more source

Dose-escalation study of carbon ion radiotherapy for locally advanced squamous cell carcinoma of the uterine cervix (9902).

, 2013
The authors performed phase I/II clinical trial to evaluate the toxicity and efficacy of carbon ion radiotherapy (C-ion RT) for locally advanced squamous cell carcinoma of the uterine cervix.journal ...
入江 大介, Kato, Shingo, Ohno, Tatsuya, 466009, Nakano, Takashi, Wakatsuki, Masaru, 若月 優, 466013, 466014, 466011, 466012, 466010, Syozu, Makio, 700631, 700630, 466019, 700633, 700632, 466017, 466018, 鎌田 正, 466015, 466016, Tsujii, Hirohiko, 700628, 700627, Kamada, Tadashi, 466022, 700629, 466020, 700624, 466021, 700626, 700625, Shozu, Makio, Kiyohara, Hiroki, 唐澤 久美子, 700640, 700639, 700638, Karasawa, Kumiko, 700635, 生水 真紀夫, 700634, 700637, 700636, Wakatuki, Masaru, 辻井 博彦, Ando, Ken, Irie, Daisuke, 加藤 眞吾   +50 more
core  

Carbon Ion Radiotherapy for Prostate Cancer

Carbon Ion Radiotherapy for Prostate Cancer
NIRS-IMP Joint Symposium on Carbon Ion ...
  +8 more sources

Carbon Ion Radiotherapy for Postoperative Recurrence of Rectal Cancer

： To improve long-term local control and survival of locally recurrent rectal cancer, we have initiated a radiation dose-escalation trial using carbon ion beams.
安田 茂雄, Shinoto, Makoto, Yasuda, Shigeo, 篠藤 誠, Terashima, Koutaro, 寺嶋 広太郎, 555896, 555897, 555898, 555899, Isozaki, Teturou, Endo, Satoshi, 磯崎 哲朗, 塩見 美帆, 遠藤 悟史, 555892, 555893, 555894, 555895, 555890, 555891, 555889, 555900, 555887, 555888, 山田 滋, Shiomi, Miho, Yamada, Shigeru   +27 more
core  

Monte Carlo simulation of out-of-field dose distribution in carbon-ion radiotherapy with passive beam

, 2012
The National Institute of Radiological Sciences (NIRS) has achieved remarkable results in clinical trials and clinical practices for cancer treatment with carbon-ion radiotherapy at the Heavy-Ion Medical Accelerator in Chiba (HIMAC).
Yonai, Shunsuke, Matsufuji, Naruhiro, 694991, 米内 俊祐, 694987, 694986, 694989, Namba, Masao, 694988, 難波 将夫, 松藤 成弘, 694990   +11 more
core