Results 151 to 160 of about 5,822,485 (294)

Status of Carbon-Ion Therapy Facility and Development for Advanced Treatment

, 2007
1.Heavy-ion radiotherapy has two clear advantages over other types of radiation therapies. One is the localized dose distribution just on a tumor in a human body.
北川 敦志, 615063, 615064, Kitagawa, Atsushi   +3 more
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AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Application of lung substitute material as ripple filter for multi-ion therapy with helium-, carbon-, oxygen-, and neon-ion beams

A development project for hypo-fractionated multi-ion therapy has been initiated at the National Institute of Radiological Sciences in Japan. In the treatment, helium, carbon, oxygen, and neon ions will be used as primary beams with pencil beam scanning.
Nakaji, Taku, Masao, Suzuki, Toshiyuki, Shirai, Mizushima, Kota, Shinji, Sato, 1012292, 1012291, Sato, Shinji, 1012296, Nobuyuki, Kanematsu, Inaniwa, Taku, 1012295, 1012294, Yoshiyuki, Iwata, 1012293, 1012311, 1012299, 1012310, 1012298, 1012297, Abe, Yasushi, 1012312, Iwata, Yoshiyuki, Taku, Nakaji, Kota, Mizushima, Yasushi, Abe, Sakata, Dousatsu, Hyun Lee, Sung, Shirai, Toshiyuki, 1012300, Taku, Inaniwa, Kanematsu, Nobuyuki, 1012304, 1012303, Dousatsu, Sakata, 1012302, 1012301, 1012308, Suzuki, Masao, 1012307, 1012306, 1012305, Sung-Hyun, Lee, 1012309   +43 more
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Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Bevacizumab is an effective treatment for symptomatic cerebral necrosis after carbon ion therapy for recurrent intracranial malignant tumours: A case report. [PDF]

Mol Clin Oncol, 2022
Liu R, Luo H, Zhang Q, Sun S, Liu Z, Wang X, Geng Y, Zhao X.   +7 more
europepmc   +1 more source

8.2.6　Fractionation in Carbon-Ion Therapy

RADIOISOTOPES, 2019
Yukari Yoshida, Akihisa Takahashi, Koichi Ando   +2 more
openaire   +2 more sources

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

Potential role of functional imaging in predicting outcome for patients treated with carbon ion therapy: a review. [PDF]

Br J Radiol, 2021
Riva G, Imparato S, Savietto G, Pecorilla M, Iannalfi A, Barcellini A, Ronchi S, Fiore MR, Paganelli C, Buizza G, Ciocca M, Baroni G, Preda L, Orlandi E.   +13 more
europepmc   +1 more source

ES 10.04 Carbon-ion Therapy [PDF]

Journal of Thoracic Oncology, 2017
openaire   +1 more source

Recent Progress on HIMAC for Carbon Therapy

An impressive advance of the carbon-ion therapy using the HIMAC has been supported by a highreliability operation and a development of accelerator technologies.
Mizushima, Kota, 武井 由佳, Mori, Shinichiro, Noda, Kouji, 556212, 556211, 556214, 556213, Inaniwa, Taku, Minohara, Shinichi, 556210, et.al, Kanai, Tatsuaki, 556209, 556208, 556205, 556204, 556207, 556206, Takada, Eiichi, Furukawa Takuji, 高田 栄一, 556201, 556200, 556203, 556202, Satou, Shinji, 佐藤 眞二, 白井 敏之, 野田 耕司, 稲庭 拓, 村上 健, 森 慎一郎, 556197, Iwata, Yoshihisa, 556199, 556198, Murakami, Takeshi, Saotome, Naoya, 岩田 佳之, 水島 康太, Kanazawa, Mitsutaka, Takei, Yuka, 556223, 556222, 金井 達明, Shirai, Toshiyuki, 556224, 古川 卓司, 556221, 556220, 556219, 556216, 556215, 556218, 556217   +55 more
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