Results 161 to 170 of about 5,822,485 (294)

Restoration of m6A‐Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention

Advanced Science, EarlyView.
An m6A‐modified circRNA, circPSMB1, is identified as a tumor suppressor in chordoma. METTL3‐dependent m6A promotes circPSMB1 interaction with HNRNPA2B1, limiting c‐MYC expression and malignant progression. An injectable HMnO2‐based nanohydrogel enables local circPSMB1 delivery and tumor microenvironment‐responsive therapy, offering a promising strategy
Yingchuang Tang, Liang Qiu, Xingbang Ruan, Yihan Shi, Ye Wang, Hanwen Li, Kai Zhang, Kangwu Chen   +7 more
wiley   +1 more source

Pragmatic, Prospective Comparative Effectiveness Trial of Carbon Ion Therapy, Surgery, and Proton Therapy for the Management of Pelvic Sarcomas (Soft Tissue/Bone) Involving the Bone: The PROSPER Study Rationale and Design. [PDF]

Cancers (Basel), 2023
Hoppe BS, Petersen IA, Wilke BK, DeWees TA, Imai R, Hug EB, Fiore MR, Debus J, Fossati P, Yamada S, Orlandi E, Zhang Q, Bao C, Seidensaal K, May BC, Harrell AC, Houdek MT, Vallow LA, Rose PS, Haddock MG, Ashman JB, Goulding KA, Attia S, Krishnan S, Mahajan A, Foote RL, Laack NN, Keole SR, Beltran CJ, Welch EM, Karim M, Ahmed SK.   +31 more
europepmc   +1 more source

Hyper‐Intense Tumor Peripheral Accumulation of Antibody‐Conjugated Iron Oxide Nanoparticles can Enable Breast Cancer Detection by Magnetic Particle Imaging

Advanced Science, EarlyView.
Tumor‐associated inflammation retains antibody‐targeted or non‐specific antibody conjugated nanoparticles within the tumor microenvironment. Magnetic Particle Imaging (MPI) enables non‐invasive detection and differentiation of tumors from other organs, owing to higher nanoparticle retention by inflammatory cells in the tumor periphery.
Preethi Korangath, Hayden Carlton, Theresa Wong, Sean Healy, Toby Sanders, Mason Song, Patrick W. Goodwill, Cordula Grüttner, Kathleen Gabrielson, Robert Ivkov   +9 more
wiley   +1 more source

Transformer-based rapid dose calculation for carbon ion therapy. [PDF]

Med Phys
Liu Y, Hu Y, He P, Zhao Y, Li Q.
europepmc   +1 more source

Multicenter study of carbon-ion radiation therapy for nonsquamous cell carcinomas of the oral cavity

The aim of this study was to evaluate the efficacy and safety of carbon-ion radiation therapy for nonsquamous cell carcinomas of the oral cavity in a multicenter study.journal ...
896948, 896949, Suefuji, Hiroaki, 896944, 896945, Ohno, Tatsuya, 896946, 896947, Koto, Masashi, 896940, Nakano, Takashi, 896962, 896941, 896942, 896943, 896950, Nemoto, Kenji, Takagi, Ryo, Ikawa, Hiroaki, 896959, 896939, Jun-Ichi, Saitoh, Okimoto, Tomoaki, 896955, 896956, 896957, 896958, Hayashi, Kazuhiko, 896951, 896952, 896953, 896954, Kamada, Tadashi, 896960, 896961, Demizu, Yusuke, Shioyama, Yoshiyuki   +36 more
core  

Overview of Carbon Ion Radiotherapy

, 2012
In cancer radiotherapy (RT), ion beams such as proton and carbon ion beams have unique characteristics of improved dose distributions, enabling a delivery of sufficient dose to the target volume while minimizing the dose in the surrounding normal tissues.
Tsujii, Hirohiko, 636024, 636023, 636505, 辻井 博彦, 636506   +5 more
core  

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

Impact of robust optimization and beam configuration on the distribution stability of LET under delivery uncertainties in carbon-ion therapy. [PDF]

J Appl Clin Med Phys
Phongprapun W, Tashiro M.
europepmc   +1 more source

Including Volume Effects in Biological Treatment Plan Optimization for Carbon Ion Therapy: Generalized Equivalent Uniform Dose-Based Objective in TRiP98. [PDF]

Front Oncol, 2022
Battestini M, Schwarz M, Krämer M, Scifoni E.   +3 more
europepmc   +1 more source

Biological characteristics of carbon-ion therapy

Biological characteristics of carbon-ion therapy
Purpose: Radiotherapy using charged and/or high-linear energy transfer (LET) particles has a long history, starting with proton beams up to now carbon-ions. Radiation quality of particle beams is different from conventional photons, and therefore the biological effects of high-LET irradiation have attracted scientific interests of many scientists in ...
openaire   +1 more source