Results 171 to 180 of about 5,822,485 (294)

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

Vision and implementation for the first U.S. carbon ion therapy center part II: Design philosophy and clinical implementation. [PDF]

J Appl Clin Med Phys
Liang X, Beltran CJ.
europepmc   +1 more source

A Preclinical Multifunctional Capsule Robot with Unified Diagnosis and Targeted Thermal Therapy for Gastrointestinal Diseases

Advanced Science, EarlyView.
A proof‐of‐concept multifunctional capsule robot integrates diagnostic imaging, magnetic navigation, wireless power transfer, and targeted thermotherapy for gastrointestinal applications. Magnetically guided positioning and stable wireless power enable localized thermal ablation, achieving controlled heating and high cell mortality in vitro.
Heng Zhang, Yichong Sun, Xiaoting Zhang, Chi‐Kwan Lee, Zheng Li, Yehui Li, Huarong Chen, Paul D. Mitcheson   +7 more
wiley   +1 more source

Vision and implementation for the first U.S. carbon ion therapy center part I: Clinical rationale and the need for CIRT in the United States. [PDF]

J Appl Clin Med Phys
Liang X, Beltran CJ.
europepmc   +1 more source

Dosimetric impact of using a commercial metal artifact reduction tool in carbon ion therapy in patients with hip prostheses. [PDF]

J Appl Clin Med Phys, 2021
Zhao J, Wang W, Shahnaz K, Wu X, Mao J, Li P, Zhang Q.   +6 more
europepmc   +1 more source

Carbon-ion radiotherapy for urological cancers

: Carbon-ions are charged particles with a high linear energy transfer, and therefore, they make a better dose distribution with greater biological effects on the tumors compared with photons and protons.
Tsuji Hiroshi, Kanematsu Nobuyuki, Imai Reiko, Hiroshima Yuichi, Hitoshi Ishikawa, Hiroyoshi Suzuki, Wakatsuki Masaru, Koichiro Akakura, Inaniwa Taku, Shirai Toshiyuki, Tomohiko Ichikawa   +10 more
core  

Quantitative Visualization of Intracellular Nanometabolism Using Peak‐Shifted Dual‐State Emissive FRET Nanoprobes

Advanced Science, EarlyView.
This study reveals the long‐elusive intracellular dissolution mechanism of carrier‐free nanomedicines. By utilizing peak‐shifted dual‐state emissive FRET nanoprobes (PDFNPs) that undergo a distinct ratiometric fluorescence peak shift upon disassembly, we achieve real‐time, quantitative tracking of dissolution kinetics in live cells.
Farsai Taemaitree, Jinwoo Sung, Yutaro Miki, Ryuju Suzuki, Yoshitaka Koseki, Kunikazu Ishii, Minsang Kim, Keita Tanita, Kota Sato, Toru Nakazawa, Satoshi Katsube, Daisuke Unabara, Tasuku Hamaguchi, Keisuke Kawakami, Koji Yonekura, Akihide Hibara, Atsushi Wakamiya, Hiroshi Uji‐I, Hitoshi Kasai   +18 more
wiley   +1 more source

Study of prompt gamma and neutron emission for real-time range verification in proton and carbon-ion therapy. [PDF]

Med Phys
Bellotti ES, Mazzucconi D, Bortot D, Pola A, Fiorini C, Urban K, Agosteo S.   +6 more
europepmc   +1 more source

Dosimetry and RBE in carbon ion therapy

Dosimetry and RBE in carbon ion therapy
NIRS-MD Anderson Symposium on Clinical Issues for Particle ...
openaire   +1 more source

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source