Carbonic Anhydrase II Activators in Osteopetrosis Treatment: A Review [PDF]
Current Issues in Molecular Biology, 2023 Osteopetrosis is a rare hereditary illness generated by failure in osteoclasts resulting in elevated bone densities. Patients with osteopetrosis possess several complications, like dental caries, earlier teeth loss, delayed eruption, malformed crowns and
Zikra Alkhayal +3 more
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Bioinformatics Approach Based Research of Profile Protein Carbonic Anhydrase II Analysis as a Potential Candidate Cause Autism for The Variation of Learning Subjects Biotechnology [PDF]
JPBI (Jurnal Pendidikan Biologi Indonesia), 2017 This study aims to determine the needs of learning variations on Biotechnology courses using bioinformatics approaches. One example of applied use of bioinformatics in biotechnology course is the analysis of protein profiles carbonic anhydrase II as a ...
Dian Eka A. F. Ningrum +2 more
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5-(Sulfamoyl)thien-2-yl 1,3-oxazole inhibitors of carbonic anhydrase II with hydrophilic periphery [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Hydrophilic derivatives of an earlier described series of carbonic anhydrase inhibitors have been designed, prepared and profiled against a panel of carbonic anhydrase isoforms, including the glaucoma-related hCA II.
Stanislav Kalinin +8 more
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Blessing in disguise: when head trauma solves the riddle of carbonic anhydrase II deficiency [PDF]
Radiology Case Reports, 2022 Carbonic anhydrase II deficiency is a rare autosomal recessive disorder with a classical triad of renal tubular acidosis, intracerebral calcifications and osteopetrosis.
Yazan O. Al Zu'bi +3 more
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Quinazolinones as Competitive Inhibitors of Carbonic Anhydrase-II (Human and Bovine): Synthesis, in-vitro, in-silico, Selectivity, and Kinetics Studies [PDF]
Frontiers in Chemistry, 2020 Carbonic anhydrase-II (CA-II) is associated with glaucoma, malignant brain tumors, and renal, gastric, and pancreatic carcinomas and is mainly involved in the regulation of the bicarbonate concentration in the eyes. CA-II inhibitors can be used to reduce
Ajmal Khan +6 more
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Carbonic Anhydrase II Deficiency: Unusual Presentation of the Arabic Mutation. A Case Report [PDF]
Global Pediatric HealthCarbonic anhydrase II deficiency is an extremely rare inborn error of metabolism that constitutes a triad osteopetrosis, renal tubular acidosis and intracerebral calcification.
Yazeed Alayed MD +2 more
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Synthesis and Enzymatic Evaluation of a Small Library of Substituted Phenylsulfonamido-Alkyl Sulfamates towards Carbonic Anhydrase II [PDF]
MoleculesA small library of 79 substituted phenylsulfonamidoalkyl sulfamates, 1b–79b, was synthesized starting from arylsulfonyl chlorides and amino alcohols with different numbers of methylene groups between the hydroxyl and amino moieties yielding intermediates
Toni C. Denner +3 more
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Aspirin: A Suicide Inhibitor of Carbonic Anhydrase II [PDF]
Biomolecules, 2020 Carbonic anhydrase II (CAII) is a metalloenzyme that catalyzes the reversible hydration/dehydration of CO2/HCO3−. In addition, CAII is attributed to other catalytic reactions, including esterase activity. Aspirin (acetyl-salicylic acid), an everyday over-
Jacob Andring +2 more
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Journal of Pharmacy and Bioallied SciencesA four-leaf water clover (Marsilea species) has been reported to exhibit various biological activities. In the present study, we aimed to evaluate 23 selected constituents of a four-leaf water clover (Marsilea species) as potent inhibitory agents of ...
Rithanyaa Ramesh +1 more
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Frontiers in Chemistry, 2021 A series of novel 1H-1,2,3-triazole analogs (9a–j) were synthesized via “Click” chemistry and Suzuki–Miyaura cross-coupling reaction in aqueous medium. The compounds were evaluated for their carbonic anhydrase-II enzyme inhibitory activity in vitro.
Satya Kumar Avula +8 more
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