Carbonic Anhydrase II Activators in Osteopetrosis Treatment: A Review [PDF]
Current Issues in Molecular Biology, 2023 Osteopetrosis is a rare hereditary illness generated by failure in osteoclasts resulting in elevated bone densities. Patients with osteopetrosis possess several complications, like dental caries, earlier teeth loss, delayed eruption, malformed crowns and
Zikra Alkhayal +3 more
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Aspirin: A Suicide Inhibitor of Carbonic Anhydrase II [PDF]
Biomolecules, 2020 Carbonic anhydrase II (CAII) is a metalloenzyme that catalyzes the reversible hydration/dehydration of CO2/HCO3−. In addition, CAII is attributed to other catalytic reactions, including esterase activity. Aspirin (acetyl-salicylic acid), an everyday over-
Jacob Andring +2 more
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5-(Sulfamoyl)thien-2-yl 1,3-oxazole inhibitors of carbonic anhydrase II with hydrophilic periphery [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Hydrophilic derivatives of an earlier described series of carbonic anhydrase inhibitors have been designed, prepared and profiled against a panel of carbonic anhydrase isoforms, including the glaucoma-related hCA II.
Stanislav Kalinin +8 more
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Bioinformatics Approach Based Research of Profile Protein Carbonic Anhydrase II Analysis as a Potential Candidate Cause Autism for The Variation of Learning Subjects Biotechnology [PDF]
JPBI (Jurnal Pendidikan Biologi Indonesia), 2017 This study aims to determine the needs of learning variations on Biotechnology courses using bioinformatics approaches. One example of applied use of bioinformatics in biotechnology course is the analysis of protein profiles carbonic anhydrase II as a ...
Dian Eka A. F. Ningrum +2 more
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Development of Human Carbonic Anhydrase II Heterobifunctional Degraders. [PDF]
J Med Chem, 2023 Human carbonic anhydrase II (hCAII) is a metalloenzyme essential to critical physiological processes in the body. hCA inhibitors are used clinically for the treatment of indications ranging from glaucoma to epilepsy. Targeted protein degraders have emerged as a promising means of inducing the degradation of disease-implicated proteins by using the ...
O'Herin CB +5 more
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Ibuprofen: a weak inhibitor of carbonic anhydrase II. [PDF]
Acta Crystallogr F Struct Biol Commun, 2022 Carbonic anhydrases (CAs) are drug targets for a variety of diseases. While many clinically relevant CA inhibitors are sulfonamide-based, novel CA inhibitors are being developed that incorporate alternative zinc-binding groups, such as carboxylic acid moieties, to develop CA isoform-specific inhibitors. Here, the X-ray crystal structure of human CA II (
Combs J, Andring J, McKenna R.
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Blessing in disguise: when head trauma solves the riddle of carbonic anhydrase II deficiency [PDF]
Radiology Case Reports, 2022 Carbonic anhydrase II deficiency is a rare autosomal recessive disorder with a classical triad of renal tubular acidosis, intracerebral calcifications and osteopetrosis.
Yazan O. Al Zu'bi +3 more
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Quinazolinones as Competitive Inhibitors of Carbonic Anhydrase-II (Human and Bovine): Synthesis, in-vitro, in-silico, Selectivity, and Kinetics Studies [PDF]
Frontiers in Chemistry, 2020 Carbonic anhydrase-II (CA-II) is associated with glaucoma, malignant brain tumors, and renal, gastric, and pancreatic carcinomas and is mainly involved in the regulation of the bicarbonate concentration in the eyes. CA-II inhibitors can be used to reduce
Ajmal Khan +6 more
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Carbonic Anhydrase Type II Deficiency Syndrome
Pediatric Neurology Briefs, 2012 Researchers at King Saud University, Saudi Arabia and other centers describe the neurological, neuro-ophthalmological and neuroradiological features of 23 patients (10 male, 13 female; age at final exam 2-29 years) from 10 unrelated consanguineous ...
J Gordon Millichap
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Carbonic Anhydrase II Deficiency: Unusual Presentation of the Arabic Mutation. A Case Report [PDF]
Global Pediatric HealthCarbonic anhydrase II deficiency is an extremely rare inborn error of metabolism that constitutes a triad osteopetrosis, renal tubular acidosis and intracerebral calcification.
Yazeed Alayed MD +2 more
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