Synthesis of New 1H-1,2,3-Triazole Analogs in Aqueous Medium via "Click" Chemistry: A Novel Class of Potential Carbonic Anhydrase-II Inhibitors. [PDF]
Front Chem, 2021 A series of novel 1H-1,2,3-triazole analogs (9a–j) were synthesized via “Click” chemistry and Suzuki–Miyaura cross-coupling reaction in aqueous medium. The compounds were evaluated for their carbonic anhydrase-II enzyme inhibitory activity in vitro.
Avula SK +7 more
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Quinazolinones as Competitive Inhibitors of Carbonic Anhydrase-II (Human and Bovine): Synthesis, in-vitro, in-silico, Selectivity, and Kinetics Studies. [PDF]
Front Chem, 2020 Carbonic anhydrase-II (CA-II) is associated with glaucoma, malignant brain tumors, and renal, gastric, and pancreatic carcinomas and is mainly involved in the regulation of the bicarbonate concentration in the eyes. CA-II inhibitors can be used to reduce
Khan A +5 more
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Salivary carbonic anhydrase II in winged aphid morph facilitates plant infection by viruses. [PDF]
Proc Natl Acad Sci U S A, 2023 Significance The risk for pandemic diseases caused by viruses is increasing as the dispersal rate of their arthropod vectors increases. Viruses are delivered into their hosts together with vectors’ saliva via stylet injection.
Guo H +7 more
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Carbonic Anhydrase II Activators in Osteopetrosis Treatment: A Review. [PDF]
Curr Issues Mol Biol, 2023 Osteopetrosis is a rare hereditary illness generated by failure in osteoclasts resulting in elevated bone densities. Patients with osteopetrosis possess several complications, like dental caries, earlier teeth loss, delayed eruption, malformed crowns and
Alkhayal Z +3 more
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5-(Sulfamoyl)thien-2-yl 1,3-oxazole inhibitors of carbonic anhydrase II with hydrophilic periphery. [PDF]
J Enzyme Inhib Med Chem, 2022 Hydrophilic derivatives of an earlier described series of carbonic anhydrase inhibitors have been designed, prepared and profiled against a panel of carbonic anhydrase isoforms, including the glaucoma-related hCA II.
Kalinin S +8 more
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Acta Dermato-Venereologica, 2018 Carbonic anhydrases are ubiquitously expressed enzymes that reversibly hydrate carbon dioxide to bicarbonate and protons. While the main function of carbonic anhydrases is to regulate pH and osmotic balance, their involvement in other physiological ...
Bani Kaur Suri +2 more
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Blessing in disguise: when head trauma solves the riddle of carbonic anhydrase II deficiency. [PDF]
Radiol Case Rep, 2022 Carbonic anhydrase II deficiency is a rare autosomal recessive disorder with a classical triad of renal tubular acidosis, intracerebral calcifications and osteopetrosis.
Al Zu'bi YO +3 more
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Carbonic Anhydrase II Binds to and Enhances Activity of the Na+/H+ Exchanger [PDF]
Journal of Biological Chemistry, 2002 We examined the ability of carbonic anhydrase II to bind to and affect the transport efficiency of the NHE1 isoform of the mammalian Na+/H+ exchanger. The C-terminal region of NHE1 was expressed in Escherichia coli fused with an N-terminal glutathionineS-
Xiuju Li +4 more
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Azobenzene-based inhibitors of human carbonic anhydrase II
Beilstein Journal of Organic Chemistry, 2015 Aryl sulfonamides are a widely used drug class for the inhibition of carbonic anhydrases. In the context of our program of photochromic pharmacophores we were interested in the exploration of azobenzene-containing sulfonamides to block the catalytic ...
Leander Simon Runtsch +5 more
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Synthesis and Enzymatic Evaluation of a Small Library of Substituted Phenylsulfonamido-Alkyl Sulfamates towards Carbonic Anhydrase II. [PDF]
MoleculesA small library of 79 substituted phenylsulfonamidoalkyl sulfamates, 1b–79b, was synthesized starting from arylsulfonyl chlorides and amino alcohols with different numbers of methylene groups between the hydroxyl and amino moieties yielding intermediates
Denner TC +3 more
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