Results 21 to 30 of about 130,822 (183)

Carbonic anhydrase II deficiency identified as the primary defect in the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification.

Proceedings of the National Academy of Sciences of the United States of America, 1983
The clinical, radiological, and pathological findings in three siblings affected with the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification have been reported.
W. Sly, D. Hewett‐Emmett, M. Whyte, Y. S. Yu, R. Tashian   +4 more
semanticscholar   +1 more source

A Proof-of-Concept Fragment Screening of a Hit-Validated 96-Compounds Library against Human Carbonic Anhydrase II

Biomolecules, 2020
Fragment screening is a powerful tool to identify and characterize binding pockets in proteins. We herein present the results of a proof-of-concept screening campaign of a versatile 96-entry fragment library from our laboratory against the drug target ...
Steffen Glöckner, Andreas Heine, Gerhard Klebe   +2 more
doaj   +1 more source

The Human Carbonic Anhydrase II in Platelets: An Underestimated Field of Its Activity

BioMed Research International, 2018
Carbonic anhydrases constitute a group of enzymes that catalyse reversible hydration of carbon dioxide leading to the formation of bicarbonate and proton.
M. Jakubowski, E. Szahidewicz-Krupska, A. Doroszko   +2 more
semanticscholar   +1 more source

Structural insights into a thermostable variant of human carbonic anhydrase II

Protein Science, 2018
Carbonic anhydrase is an enzyme of interest for many biotechnological developments including carbon sequestration. These applications often require harsh conditions, so there is a need for the development of thermostable variants.
K. M. Kean, Joseph J. Porter, R. Mehl, P. Karplus   +3 more
semanticscholar   +1 more source

Synthesis, molecular modelling and QSAR study of new N-phenylacetamide-2-oxoindole benzensulfonamide conjugates as carbonic anhydrase inhibitors with antiproliferative activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
In continuation of our previous studies to optimise potent carbonic anhydrase inhibitors, two new series of isatin N-phenylacetamide based sulphonamides were synthesised and screened for their human (h) carbonic anhydrase (EC 4.2.1.1) inhibitory ...
Mona F. Said, Riham F. George, Andrea Petreni, Claudiu T. Supuran, Nada M. Mohamed   +4 more
doaj   +1 more source

Mitochondrial proteomic profiling reveals increased carbonic anhydrase II in aging and neurodegeneration

Aging, 2016
Carbonic anhydrase inhibitors are used to treat glaucoma and cancers. Carbonic anhydrases perform a crucial role in the conversion of carbon dioxide and water into bicarbonate and protons.
Amelia K. Pollard, F. Shephard, James Freed, S. Liddell, L. Chakrabarti   +4 more
semanticscholar   +1 more source

Neutron structure of human carbonic anhydrase II in complex with methazolamide: mapping the solvent and hydrogen-bonding patterns of an effective clinical drug

IUCrJ, 2016
The room-temperature X-ray/neutron structure of human carbonic anhydrase II in complex with methazolamide has been determined. The study provides new insights into the hydrogen-bonding changes that take place within the active site of an enzyme upon drug
M. Aggarwal, A. Kovalevsky, Hector A. Velazquez, Hector A. Velazquez, S. Z. Fisher, Jeremy C. Smith, Jeremy C. Smith, R. McKenna   +7 more
semanticscholar   +1 more source

Inhibitory effects of sulfenimides on human and bovine carbonic anhydrase enzymes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
A series of sulfenimide derivatives (1a-i) were investigated as inhibitors of human (hCA-I, hCA-II) and bovine (bCA) carbonic anhydrase enzymes. The compounds were synthesised by the reaction of substituted thiophenols with phthalimide by means of an ...
Hasan Yakan, Gürkan Bilir, Şükriye Çakmak, Ömer Taş, Nalan Türköz Karakullukçu, Ercan Soydan, Halil Kütük, Coşkun Güçlü, Murat Şentürk, Tayfun Arslan, Seyhan Öztürk, Ercüment Aksakal, Deniz Ekinci   +12 more
doaj   +1 more source

Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
The isatin scaffold is the constitutive fragment of several natural and synthetic bioactive molecules. Albeit several benzene sulphonamide-based carbonic anhydrase inhibitors (CAIs) have been reported, only recently isatin benzene sulphonamides have been
Claudia Melis, Rita Meleddu, Andrea Angeli, Simona Distinto, Giulia Bianco, Clemente Capasso, Filippo Cottiglia, Rossella Angius, Claudiu T. Supuran, Elias Maccioni   +9 more
doaj   +1 more source

Carbonic anhydrase II as host protein for the creation of a biocompatible artificial metathesase.

Organic and biomolecular chemistry, 2015
An artificial metathesase results from incorporation of an Hoveyda-Grubbs catalyst bearing an arylsulfonamide anchor within human carbonic anhydrase II.
Jingming Zhao, Anna Kajetanowicz, T. Ward   +2 more
semanticscholar   +1 more source