Results 21 to 30 of about 66,240 (319)

Effect of Anti-Carbonic Anhydrase Antibodies on Carbonic Anhydrases I and II [PDF]

Clinical Chemistry, 2003
Carbonic anhydrase (CA; EC 4.2.1.1) is a zinc enzyme that is widely distributed in the living world and is involved in many biochemical processes that depend on the hydration/dehydration of carbon dioxide/bicarbonate [reviewed in Refs. (1)(2)(3)(4)(5)(6)].
BOTRE', Francesco, BOTRE', Claudio, E. Podesta, M. Podda, P. Invernizzi   +4 more
openaire   +3 more sources

Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
The present study aimed to develop potent carbonic anhydrase inhibitors (CAIs). The design of the target compounds was based on modifying the structure of the ureido-based carbonic anhydrase inhibitor SLC-0111.
Mazin A. A. Najm, Walaa R. Mahmoud, Azza T. Taher, Safinaz E-S. Abbas, Fadi M. Awadallah, Heba Abdelrasheed Allam, Daniela Vullo, Claudiu T. Supuran   +7 more
doaj   +1 more source

Microwave assisted solvent-free mannich bases: synthesis, characterization and effects of these compounds on HCA I and HCA II isozymes

Macedonian Journal of Chemistry and Chemical Engineering, 2021
Mannich bases (2a–d) of aromatic amines were synthesized by using a conventional microwave technique under solvent-free conditions and characterized by IR and NMR (1H and 13C) and elemental analysis.
Bülent Büyükkıdan, Nurgün Büyükkıdan, Metin Bülbül, Melek Yılmaz, Evren Derrun Arslanbay, Ekrem Tunca   +5 more
doaj   +1 more source

Atomic resolution studies of carbonic anhydrase II [PDF]

Acta Crystallographica Section D Biological Crystallography, 2010
Carbonic anhydrase has been well studied structurally and functionally owing to its importance in respiration. A large number of X-ray crystallographic structures of carbonic anhydrase and its inhibitor complexes have been determined, some at atomic resolution.
Craig A, Behnke, Isolde, Le Trong, Jeff W, Godden, Ethan A, Merritt, David C, Teller, Jürgen, Bajorath, Ronald E, Stenkamp   +6 more
openaire   +2 more sources

Carbonic anhydrase isozymes IV and II in urinary membranes from carbonic anhydrase II-deficient patients. [PDF]

Proceedings of the National Academy of Sciences, 1990
Carbonic anhydrase II (CA II) deficiency has been shown to be the primary defect in the recessively inherited syndrome of osteopetrosis with renal tubular acidosis. Until now, the absence of CA II in kidney of CA II-deficient patients has not been shown directly, and the status of the membrane-associated CA in kidney of CA II-deficient patients has ...
S, Sato, X L, Zhu, W S, Sly
openaire   +2 more sources

The effects of cardiac drugs on human erythrocyte carbonic anhydrase I and II isozymes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Cardiovascular diseases are the leading cause of mortality worldwide. In recent years, the relationship between carbonic anhydrase inhibitors and atherosclerosis has attracted attention.
Onur Argan, Kübra Çıkrıkçı, Aybike Baltacı, Nahit Gencer   +3 more
doaj   +1 more source

Mitochondrial proteomic profiling reveals increased carbonic anhydrase II in aging and neurodegeneration [PDF]

, 2016
Carbonic anhydrase inhibitors are used to treat glaucoma and cancers. Carbonic anhydrases perform a crucial role in the conversion of carbon dioxide and water into bicarbonate and protons.
Beal, Burkhard, Béchet, Chakrabarti, Corvin, Crowston, Edsall, Farrer, Fliegel, Fox, Ganie, Greenwald, Griffiths, Hansson, Hoyer, Hu, Izzotti, Jackson, Jacobson, Kassab, La Spada, La Spada, La Spada, Larsson, Levine, MacCoss, Masereel, Munnich, Nehrke, Ohlendieck, Ohlendieck, Perreault, Protasi, Rostagno, Schrattenholz, Serrano, Setou, Song, Stiernagle, Supuran, Supuran, Swenson, Swietach, Vieta, Worrall, Zhou   +45 more
core   +2 more sources

A De Novo Designed Metalloenzyme for the Hydration of CO 2 [PDF]

, 2014
Protein design will ultimately allow for the creation of artificial enzymes with novel functions and unprecedented stability. To test our current mastery of nature’s approach to catalysis, a Zn II metalloenzyme was prepared using de novo design.
Brown, Brown, Bryson, Chakraborty, Der, Faiella, Fierke, Huguet, Hunt, Jackman, Jewell, Kaplan, Khalifah, Khare, Koziol, Krebs, Looney, Nakata, Nakata, Reig, Richardson, Rufo, Slebocka-Tilk, Song, Tegoni, Walsh, Walsh, Woolley, Yamaguchi, Yu, Zastrow, Zastrow, Zhang, Zhang   +33 more
core   +1 more source

Preclinical Evaluation of Ureidosulfamate Carbonic Anhydrase IX/XII Inhibitors in the Treatment of Cancers [PDF]

, 2019
Carbonic anhydrases (CAs) are a family of enzymes involved in the pH regulation of metabolically active cells/tissues. Upregulation of the CAIX/XII isoforms is associated with hypoxic tumours and clinically linked with malignant progression, treatment ...
Gieling, Roben, Williams, Kaye J.
core   +2 more sources

A glycosylphosphatidylinositol-anchored carbonic anhydrase-related protein of Toxoplasma gondii is important for rhoptry biogenesis and virulence [PDF]

, 2017
Carbonic anhydrase-related proteins (CARPs) have previously been described as catalytically inactive proteins closely related to α-carbonic anhydrases (α-CAs).
Beejan Asady, Isabelle Coppens, Jessica C. Kissinger, Leandro Lemgruber, Nathan M. Chasen, Rossiane C. Vommaro, Silvia N. J. Moreno, William J. Sullivan   +7 more
core   +2 more sources