Results 31 to 40 of about 130,822 (183)

Structural and catalytic effects of proline substitution and surface loop deletion in the extended active site of human carbonic anhydrase II

The FEBS Journal, 2015
Bioengineering of a thermophilic enzyme starting from a mesophilic scaffold has proven to be a significant challenge, as several stabilizing elements have been proposed to be the foundation of thermal stability, including disulfide bridges, surface loop ...
C. D. Boone, Valerio Rasi, C. Tu, R. McKenna   +3 more
semanticscholar   +1 more source

Carbonic anhydrase inhibitory properties of some uracil derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Inhibitors of carbonic anhydrase (CA) have been carried out in many therapeutic applications, especially antiglaucoma activity. In this study, we investigated some uracil derivatives (4–12) to inhibit human CA I (hCA I) and II (hCA II) isoenzymes. The KI
Emir Alper Türkoğlu, Murat Şentürk, Claudiu T. Supuran, Deniz Ekinci   +3 more
doaj   +1 more source

Carbonic anhydrase inhibitory properties of phenolic sulfonamides derived from dopamine related compounds

Arabian Journal of Chemistry, 2017
The effects of some phenolic sulfonamides were determined on the cytosolic carbonic anhydrase isoenzyme I and II (hCA I and II). Both isoenzymes were purified separately from human erythrocytes, using the Sepharose-4B-l-tyrosine-sulfanilamide affinity ...
Hulya Göcer, Akın Akıncıoğlu, Süleyman Göksu, İlhami Gülçin   +3 more
doaj   +1 more source

Analysis of the Binding Moiety Mediating the Interaction between Monocarboxylate Transporters and Carbonic Anhydrase II*

Journal of Biological Chemistry, 2015
Background: Carbonic anhydrase II (CAII) augments activity of monocarboxylate transporters (MCTs) by noncatalytic interaction. Results: CAII binds to an acidic cluster with an appropriate context in the MCT C terminus.
S. I. Noor, S. Dietz, H. Heidtmann, C. D. Boone, R. McKenna, J. Deitmer, H. Becker   +6 more
semanticscholar   +1 more source

Characterization of the Copper(II) Binding Sites in Human Carbonic Anhydrase II.

Inorganic Chemistry, 2015
Human carbonic anhydrase (CA) is a well-studied, robust, mononuclear Zn-containing metalloprotein that serves as an excellent biological ligand system to study the thermodynamics associated with metal ion coordination chemistry in aqueous solution.
Whitnee L Nettles, He Song, E. Farquhar, Nicholas C. Fitzkee, Joseph P. Emerson   +4 more
semanticscholar   +1 more source

Selective inhibition of carbonic anhydrase IX by sulphonylated 1,2,3-triazole incorporated benzenesulphonamides capable of inducing apoptosis

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
In search of selective carbonic anhydrase (CA) IX inhibitors endowed with apoptotic inducing properties, we designed and synthesised two subsets of 4- and 3-(5-aryl-(4-phenylsulphonyl)-1H-1,2,3-triazol-1-yl)benzenesulphonamides.
Kiran Siwach, Amit Kumar, Harish Panchal, Rajiv Kumar, Jitender Kumar Bhardwaj, Andrea Angeli, Claudiu T. Supuran, Pawan K. Sharma   +7 more
doaj   +1 more source

Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth

Proceedings of the National Academy of Sciences of the United States of America, 2008
The regenerative process in the pancreas is of particular interest because diabetes results from an inadequate number of insulin-producing beta cells and pancreatic cancer may arise from the uncontrolled growth of progenitor/stem cells.
A. Inada, C. Nienaber, H. Katsuta, Y. Fujitani, J. Levine, Rina Morita, Arun J Sharma, S. Bonner-Weir   +7 more
semanticscholar   +1 more source

Coupling Protein Dynamics with Proton Transport in Human Carbonic Anhydrase II

Journal of Physical Chemistry B, 2016
The role of protein dynamics in enzyme catalysis is one of the most highly debated topics in enzymology. The main controversy centers around what may be defined as functionally significant conformational fluctuations and how, if at all, these ...
S. Taraphder, C. M. Maupin, J. Swanson, G. Voth   +3 more
semanticscholar   +1 more source

Bioinformatics Tools for the Analysis of Active Compounds Identified in Ranunculaceae Species

Pharmaceuticals, 2023
The chemical compounds from extracts of three Ranunculaceae species, Aconitum toxicum Rchb., Anemone nemorosa L. and Helleborus odorus Waldst. & Kit.
Cătălina Mareş, Ana-Maria Udrea, Nicoleta Anca Şuţan, Speranţa Avram   +3 more
doaj   +1 more source

Carbonic Anhydrase Type II Deficiency Syndrome

Pediatric Neurology Briefs, 2012
Researchers at King Saud University, Saudi Arabia and other centers describe the neurological, neuro-ophthalmological and neuroradiological features of 23 patients (10 male, 13 female; age at final exam 2-29 years) from 10 unrelated consanguineous ...
J Gordon Millichap
doaj   +1 more source