Results 31 to 40 of about 66,240 (319)
SLC26A Gene Family Participate in pH Regulation during Enamel Maturation. [PDF]
, 2015 The bicarbonate transport activities of Slc26a1, Slc26a6 and Slc26a7 are essential to physiological processes in multiple organs. Although mutations of Slc26a1, Slc26a6 and Slc26a7 have not been linked to any human diseases, disruption of Slc26a1 ...
Kurtz, Ira +8 more
core +7 more sources
Acta Dermato-Venereologica, 2018 Carbonic anhydrases are ubiquitously expressed enzymes that reversibly hydrate carbon dioxide to bicarbonate and protons. While the main function of carbonic anhydrases is to regulate pH and osmotic balance, their involvement in other physiological ...
Bani Kaur Suri +2 more
doaj +1 more source
Endocervical glandular neoplasia associated with lobular endocervical glandular hyperplasia is HPV-independent and correlates with carbonic anhydrase-IX expression: a Gynaecological Oncology Group Study. [PDF]
, 2013 BackgroundLobular endocervical glandular hyperplasia (LEGH) is a rare lesion of the uterine cervix. It has been proposed that LEGH may represent a precursor lesion to a group of mucinous adenocarcinoma with gastric phenotype (GA) that is independent of ...
Carter, R +9 more
core +1 more source
Biomolecules, 2020 Fragment screening is a powerful tool to identify and characterize binding pockets in proteins. We herein present the results of a proof-of-concept screening campaign of a versatile 96-entry fragment library from our laboratory against the drug target ...
Steffen Glöckner +2 more
doaj +1 more source
Challenges for the development of a biotic ligand model predicting copper toxicity in estuaries and seas [PDF]
, 2012 This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2011 SETAC.An effort is ongoing to develop a biotic ligand model (BLM) that predicts copper (Cu) toxicity in estuarine and marine ...
de Polo, A, Scrimshaw, MD
core +1 more source
Results in Chemistry, 2022 A small library of ten new Nimesulide-iminothiazolines conjugates was synthesized by the reduction of nitro group of Nimesulide followed by conversion into variously substituted acyl thioureas.
Imran Shafique +9 more
doaj +1 more source
Carbonic Anhydrases II, IX, and XII in Reflux Esophagitis [PDF]
Digestive Diseases and Sciences, 2021 The pathogenesis of gastroesophageal reflux disease (GERD) has not been resolved in detail. Esophageal epithelial cells provide resistance to acidic reflux via several mechanisms, many of which involve buffering acid with bicarbonate and transporting protons.
Minna Nortunen +5 more
openaire +5 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 In continuation of our previous studies to optimise potent carbonic anhydrase inhibitors, two new series of isatin N-phenylacetamide based sulphonamides were synthesised and screened for their human (h) carbonic anhydrase (EC 4.2.1.1) inhibitory ...
Mona F. Said +4 more
doaj +1 more source
Inhibitory effects of sulfenimides on human and bovine carbonic anhydrase enzymes
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 A series of sulfenimide derivatives (1a-i) were investigated as inhibitors of human (hCA-I, hCA-II) and bovine (bCA) carbonic anhydrase enzymes. The compounds were synthesised by the reaction of substituted thiophenols with phthalimide by means of an ...
Hasan Yakan +12 more
doaj +1 more source
The sheep conceptus modulates proteome profiles in caruncular endometrium during early pregnancy [PDF]
, 2016 This project was funded by NHS Grampian R&D project number RG05/019Peer ...
Al-Gubory, Kaïs +2 more
core +2 more sources