Results 1 to 10 of about 109,847 (333)
Five-Membered Heterocyclic Sulfonamides as Carbonic Anhydrase Inhibitors. [PDF]
Molecules, 2023 The development of heterocyclic derivatives has progressed considerably over the past decades, and many new carbonic anhydrase inhibitors (CAIs) fall into this field.
Angeli A, Paoletti N, Supuran CT.
europepmc +3 more sources
Anti-obesity carbonic anhydrase inhibitors: challenges and opportunities. [PDF]
J Enzyme Inhib Med Chem, 2022 The mitochondrial isoforms VA/VB of metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) are involved in metabolic processes, such as de novo lipogenesis and fatty acid biosynthesis.
Supuran CT.
europepmc +3 more sources
Phenols and Polyphenols as Carbonic Anhydrase Inhibitors [PDF]
Molecules, 2016 Phenols are among the largest and most widely distributed groups of secondary metabolites within the plant kingdom. They are implicated in multiple and essential physiological functions.
Anastasia Karioti +2 more
doaj +5 more sources
Repurposing FDA-approved sulphonamide carbonic anhydrase inhibitors for treatment of Neisseria gonorrhoeae. [PDF]
J Enzyme Inhib Med Chem, 2022 Neisseria gonorrhoeae is a high-priority pathogen of concern due to the growing prevalence of resistance development against approved antibiotics. Herein, we report the anti-gonococcal activity of ethoxzolamide, the FDA-approved human carbonic anhydrase ...
Abutaleb NS +8 more
europepmc +2 more sources
Topiramate as an Inhibitor of Carbonic Anhydrase Isoenzymes [PDF]
Epilepsia, 2000 Summary: Purpose: This study investigated the effectiveness of topiramate (TPM) as an inhibitor of six isozymes of carbonic anhydrase (CA). Methods: The inhibition constants (Ki) of TPM and acetazolamide (AZM) for CA I, CA II, CA III, CA IV, CA V, and CA VI were determined for human (HCA), rat (RCA), or mouse (MCA).
Susanna J. Dodgson +2 more
openalex +4 more sources
Coumarin carbonic anhydrase inhibitors from natural sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Coumarins constitute a relatively new class of inhibitors of the zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1), possessing a unique inhibition mechanism, acting as “prodrug inhibitors.” They undergo the hydrolysis of the lactone ring mediated by the ...
Claudiu T. Supuran
doaj +2 more sources
Click chemistry approaches for developing carbonic anhydrase inhibitors and their applications. [PDF]
J Enzyme Inhib Med Chem, 2023 Click chemistry reactions constitute an important and relatively new approach in the medicinal chemistry toolbox and offer substantial advantages to medicinal chemists in terms of overcoming the limitations of facile chemical synthesis, increased ...
Angeli A, Supuran CT.
europepmc +2 more sources
Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 The isatin scaffold is the constitutive fragment of several natural and synthetic bioactive molecules. Albeit several benzene sulphonamide-based carbonic anhydrase inhibitors (CAIs) have been reported, only recently isatin benzene sulphonamides have been
Claudia Melis +9 more
doaj +2 more sources
Catechols: a new class of carbonic anhydrase inhibitors.
Chemical Communications, 2020 To date, catechols have been only poorly investigated as carbonic anhydrase (CA) inhibitors. Here we report the first structural information on the CA inhibition mechanism of these molecules, showing that they adopt a peculiar binding mode to the enzyme ...
Katia D'Ambrosio +6 more
semanticscholar +5 more sources
Critical Care, 2018 Background Metabolic alkalosis is common in patients with respiratory failure and may delay weaning in mechanically ventilated patients. Carbonic anhydrase inhibitors block renal bicarbonate reabsorption, and thus reverse metabolic alkalosis.
Bassem Y Tanios +7 more
doaj +2 more sources