Synthesis of some natural sulphonamide derivatives as carbonic anhydrase inhibitors
, 2017 Carbonic anhydrase inhibitors are both in clinical use as antiglaucoma, diuretics, antiepileptics and management of altitude sickness, and under investigation as anticancer, anticonvulsant and antiobesity agents. Sulphonamides have been known for decades
T. Gokcen +5 more
semanticscholar +1 more source
Acta Ophthalmologica, EarlyView.Abstract Purpose To validate a deep learning (DL) framework for detecting and quantifying cystoid fluid collections (CFC) on spectral‐domain optical coherence tomography (SD‐OCT) in X‐linked retinoschisis (XLRS) patients. Methods A no‐new‐U‐Net model was trained using 112 OCT volumes from the RETOUCH challenge (70 for training and 42 for internal ...
Jonathan Hensman +5 more
wiley +1 more source
Calculating the energy profile of an enzymatic reaction on a quantum computer [PDF]
arXivQuantum computing (QC) provides a promising avenue toward enabling quantum chemistry calculations, which are classically impossible due to a computational complexity that increases exponentially with system size. As fully fault-tolerant algorithms and hardware, for which an exponential speedup is predicted, are currently out of reach, recent research ...
arxiv
In Silico Design, Extended Molecular Dynamic Simulations and Binding Energy Calculations for a New Series of Dually Acting Inhibitors against EGFR and HER2 [PDF]
arXiv, 2013 Starting from the lead structure we have identified in our previous works, we are extending our insight understanding of its potential inhibitory effect against both EGFR and HER2 receptors. Herein and using extended molecular dynamic simulations and different scoring techniques, we are providing plausible explanations for the observed inhibitory ...
arxiv
L‐662,583 is a topically effective ocular hypotensive carbonic anhydrase inhibitor in experimental animals [PDF]
, 1990 Michael F. Sugrue +7 more
openalex +1 more source
Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?
Acta Ophthalmologica, EarlyView.Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs +12 more
wiley +1 more source
Guiding Generative Protein Language Models with Reinforcement Learning [PDF]
arXivAutoregressive protein language models (pLMs) have emerged as powerful tools to efficiently design functional proteins with extraordinary diversity, as evidenced by the successful generation of diverse enzyme families, including lysozymes or carbonic anhydrases.
arxiv
A framework for generalized group testing with inhibitors and its potential application in neuroscience [PDF]
arXiv, 2018 The main goal of group testing with inhibitors (GTI) is to efficiently identify a small number of defective items and inhibitor items in a large set of items. A test on a subset of items is positive if the subset satisfies some specific properties. Inhibitor items cancel the effects of defective items, which often make the outcome of a test containing ...
arxiv
Complexes With Biologically Active Ligands. Part 61 Ni(II)Coordination Compounds of Hydrazine and Heterocyclic Sulfonamidesas Inhibitors of the Zinc Enzyme Carbonic Anhydrase [PDF]
, 1996 J. Borrás +6 more
openalex +1 more source
Diatom triacylglycerol metabolism: from carbon fixation to lipid droplet degradation
Biological Reviews, EarlyView.ABSTRACT Diatoms are a prominent microalgae family that has attracted interest for its production of molecules of biotechnological interest. Their fatty acid profile is rich in health‐beneficial omega‐3 eicosapentaenoic acid (EPA). Furthermore, under nutrient‐deprived conditions, many diatom species, notably Phaeodactylum tricornutum, Thalassiosira ...
Victor Murison +3 more
wiley +1 more source