Results 221 to 230 of about 42,138 (273)

Carbonic Anhydrase Inhibitors

ChemInform, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
SCOZZAFAVA, ANDREA, SUPURAN, CLAUDIU TRANDAFIR, A. CASINI   +2 more
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Antiobesity Carbonic Anhydrase Inhibitors

Current Topics in Medicinal Chemistry, 2007
Few pharmacological approaches for the treatment of obesity exist at this time, and most of them are unsatisfactory, whereas this disease is widespread both in the developed and developing world. Novel effective approaches are needed for the development of antiobesity agents possessing different mechanisms of action.
G. D. Simone, SUPURAN, CLAUDIU TRANDAFIR
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Topical carbonic anhydrase inhibitors

Current Opinion in Ophthalmology, 1997
Dorzolamide, a topically active carbonic anhydrase inhibitor, is an effective new glaucoma medication that creates a decrease in intraocular pressure similar to that produced by beta-blockers. When beta-blockers are contraindicated, dorzolamide may be used as a first-line therapy.
D M, Talluto, T B, Wyse, T, Krupin
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Topical carbonic anhydrase inhibitors

Journal of Medicinal Chemistry, 1984
Ethoxzolamide and several derivatives (1-6) were synthesized and evaluated for carbonic anhydrase inhibition (CAI), solubility, pKa, distribution, and corneal permeability. The 6-hydroxy (5) and, particularly, the 6-chloro (6) analogues have the best combination of properties for penetrating the site of action and reducing intraocular pressure.
R D, Schoenwald, M G, Eller, J A, Dixson, C F, Barfknecht   +3 more
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Carborane‐Based Carbonic Anhydrase Inhibitors

Angewandte Chemie International Edition, 2013
CA inhibitors: Human carbonic anhydrases (CAs) are diagnostic and therapeutic targets. Various carborane cages are shown to act as active-site-directed inhibitors, and substitution with a sulfamide group and other substituents leads to compounds with high selectivity towards the cancer-specific isozyme IX.
Brynda, J. (Jiří), Mader, P. (Pavel), Šícha, V. (Václav), Fábry, M. (Milan), Poncová, K. (Kristýna), Bakardjiev, M. (Mario), Grüner, B. (Bohumír), Cígler, P. (Petr), Řezáčová, P. (Pavlína)   +8 more
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Carbonic anhydrase inhibitors

Bioorganic & Medicinal Chemistry Letters, 2010
Carbonic anhydrases (CAs, EC 4.2.1.1) are widespread enzymes in all organisms, catalyzing CO2 hydration to bicarbonate and protons. Their inhibition is exploited clinically for decades for various classes of diuretics and systemically acting antiglaucoma agents.
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Sulfonylmethanesulfonamide inhibitors of carbonic anhydrase

Journal of Medicinal Chemistry, 1993
A series of sulfonylmethanesulfonamide derivatives is described, which are inhibitors of carbonic anhydrase (CA). The most potent of these is the racemic fluoro sulfone 9, which inhibits carbon dioxide hydration catalyzed by human CA II (CA-II) with an IC50 of 3 nM.
T H, Scholz, J M, Sondey, W C, Randall, H, Schwam, W J, Thompson, P J, Mallorga, M F, Sugrue, S L, Graham   +7 more
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Carbonic Anhydrase Inhibitors as Anticonvulsant Agents

Current Topics in Medicinal Chemistry, 2007
Seizures are one of the most common neurological disorders in clinical medicine. Triggering mechanisms by which seizures form remain unclear, but are related to a rapid change in ionic composition, including an increase of intracellular potassium concentration and pH shifts within the brain.
A. Thiry, J. Dogné, SUPURAN, CLAUDIU TRANDAFIR, B. Masereel   +3 more
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Dual Carbonic Anhydrase - Cyclooxygenase-2 Inhibitors

Current Topics in Medicinal Chemistry, 2007
Cyclooxygenase is a key enzyme responsible for metabolisation of arachidonic acid into prostaglandins and thromboxane. This enzyme is the target of non steroidal anti-inflammatory drugs (NSAIDs), used against inflammation and pain. The inducible COX-2 was associated with inflammatory conditions, whereas the constitutive form (COX-1) was responsible for
J. Dogné, A. Thiry, D. Pratico, B. Masereel, SUPURAN, CLAUDIU TRANDAFIR   +4 more
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Carbonic Anhydrase Inhibitors

1985
Inhibitors of carbonic anhydrase presently have a limited role in the treatment of epilepsy. Inorganic anions, such as I−, CN−, SH−, CNO−, SCN−, and Br−, and sulfonamides are inhibitors of the enzyme carbonic anhydrase (Maren 1967). Both bromides and sulfonamides have been used in the treatment of epilepsy in man.
J. E. Riggs, R. C. Griggs
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