Results 41 to 50 of about 109,847 (333)

Bioinformatics Tools for the Analysis of Active Compounds Identified in Ranunculaceae Species

Pharmaceuticals, 2023
The chemical compounds from extracts of three Ranunculaceae species, Aconitum toxicum Rchb., Anemone nemorosa L. and Helleborus odorus Waldst. & Kit.
Cătălina Mareş, Ana-Maria Udrea, Nicoleta Anca Şuţan, Speranţa Avram   +3 more
doaj   +1 more source

Dithiocarbamates effectively inhibit the α-carbonic anhydrase from Neisseria gonorrhoeae

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Recently, inorganic anions and sulphonamides, two of the main classes of zinc-binding carbonic anhydrase inhibitors (CAIs), were investigated for inhibition of the α-class carbonic anhydrase (CA, EC 4.2.1.1) from Neisseria gonorrhoeae, NgCA.
Simone Giovannuzzi, Nader S. Abutaleb, Chad S. Hewitt, Fabrizio Carta, Alessio Nocentini, Mohamed N. Seleem, Daniel P. Flaherty, Claudiu T. Supuran   +7 more
doaj   +1 more source

Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) generally by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA inhibitor but those erroneous results were subsequently corrected by ...
A. Nocentini, A. Angeli, F. Carta, J. Winum, R. Žalubovskis, S. Carradori, C. Capasso, W. Donald, C. Supuran   +8 more
semanticscholar   +1 more source

Visible‐light‐switchable azobenzenes: Molecular design, supramolecular systems, and applications

Natural Sciences, Volume 3, Issue 1, January 2023., 2023
Abstract Photocontrol of functional molecules and supramolecular systems provides promising directions for the development of innovative materials and technologies. Reversible photoswitches that can isomerize among different states play a vital role in such photoresponsive systems. However, the commonly used UV light for triggering the isomerization of
Minghao Gao, Dennis Kwaria, Yasuo Norikane, Youfeng Yue   +3 more
wiley   +1 more source

Selective inhibition of carbonic anhydrase IX by sulphonylated 1,2,3-triazole incorporated benzenesulphonamides capable of inducing apoptosis

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
In search of selective carbonic anhydrase (CA) IX inhibitors endowed with apoptotic inducing properties, we designed and synthesised two subsets of 4- and 3-(5-aryl-(4-phenylsulphonyl)-1H-1,2,3-triazol-1-yl)benzenesulphonamides.
Kiran Siwach, Amit Kumar, Harish Panchal, Rajiv Kumar, Jitender Kumar Bhardwaj, Andrea Angeli, Claudiu T. Supuran, Pawan K. Sharma   +7 more
doaj   +1 more source

In silico identification of potential natural product inhibitors of human proteases key to SARS-CoV-2 infection [PDF]

Molecules 2020, 25(17), 3822, 2020
Presently, there are no approved drugs or vaccines to treat COVID-19 which has spread to over 200 countries and is responsible for over 3,65,000 deaths worldwide. Recent studies have shown that two human proteases, TMPRSS2 and cathepsin L, play a key role in host cell entry of SARS-CoV-2.
arxiv   +1 more source

Carbonic anhydrase inhibitors: an editorial [PDF]

Expert Opinion on Therapeutic Patents, 2013
This issue of Expert Opinion on Therapeutic Patents is dedicated to carbonic anhydrase (CA, EC 4.2.1.1) inhibitors (CAIs), a highly dynamic research topic in the last years. Several review articles and patent analyses on diuretics and antiglaucoma, antiepileptic, anti-obesity and anticancer agents belonging to the pharmacological class of the CAIs are ...
openaire   +3 more sources

Multimeric xanthates as carbonic anhydrase inhibitors [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2015
The field of multivalent inhibition of enzymes is growing exponentially from the first reported multivalent effect on a glycosidase enzyme. However, the investigations have generally remained restricted to carbohydrate-processing enzymes. Carbonic anhydrases are ubiquitous metallo-enzymes involved in many key biological processes, that catalyze the ...
Muhammet Tanc, Claudiu T. Supuran, Marta Abellán-Flos, Stéphane P. Vincent   +3 more
openaire   +3 more sources

Inhibitory effects of sulfenimides on human and bovine carbonic anhydrase enzymes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
A series of sulfenimide derivatives (1a-i) were investigated as inhibitors of human (hCA-I, hCA-II) and bovine (bCA) carbonic anhydrase enzymes. The compounds were synthesised by the reaction of substituted thiophenols with phthalimide by means of an ...
Hasan Yakan, Gürkan Bilir, Şükriye Çakmak, Ömer Taş, Nalan Türköz Karakullukçu, Ercan Soydan, Halil Kütük, Coşkun Güçlü, Murat Şentürk, Tayfun Arslan, Seyhan Öztürk, Ercüment Aksakal, Deniz Ekinci   +12 more
doaj   +1 more source

Effects of Pennyroyal (Mentha pulegium L.) Supplementation on production performance, egg quality traits, and biochemical parameters of blood and egg in laying hens at later stages of the production period

Veterinary Medicine and Science, Volume 9, Issue 1, Page 242-251, January 2023., 2023
The graphical abstract image represents a pennyroyal leave and its grounded form which was supplemented in laying hens’ diet in order to evaluate its impact on the production performance, egg quality, and biochemical contents of blood and eggs in the current study.
Amir Mosayyeb Zadeh, Seyyed Ali Mirghelenj, Peyman Hasanlou, Hossein Shakouri Alishah   +3 more
wiley   +1 more source