Results 31 to 40 of about 27,386 (335)

Mitochondrial proteomic profiling reveals increased carbonic anhydrase II in aging and neurodegeneration [PDF]

, 2016
Carbonic anhydrase inhibitors are used to treat glaucoma and cancers. Carbonic anhydrases perform a crucial role in the conversion of carbon dioxide and water into bicarbonate and protons.
Beal, Burkhard, Béchet, Chakrabarti, Corvin, Crowston, Edsall, Farrer, Fliegel, Fox, Ganie, Greenwald, Griffiths, Hansson, Hoyer, Hu, Izzotti, Jackson, Jacobson, Kassab, La Spada, La Spada, La Spada, Larsson, Levine, MacCoss, Masereel, Munnich, Nehrke, Ohlendieck, Ohlendieck, Perreault, Protasi, Rostagno, Schrattenholz, Serrano, Setou, Song, Stiernagle, Supuran, Supuran, Swenson, Swietach, Vieta, Worrall, Zhou   +45 more
core   +2 more sources

Role of carbon dioxide and ion transport in the formation of sub-embryonic fluid by the blastoderm of the Japanese quail [PDF]

, 2002
1. The explanted blastoderm of the Japanese quail was used to explore the role of ions and carbon dioxide in determining the rate of sub-embryonic fluid (SEF) production between 54 and 72 h of incubation. 2.
AR A., BABIKER E.M., BECKER WA., BENOS DJ., BORON W.F., BRAKE J., COTTERILI O.J., DODGSON S.J., DODGSON S.J., EHRENFELD J., FRITSCHE C., HANSSON H.P.J., MAHEN T.H., MAREN T.H., MUELLER W.J., NEW D.A.T., NEW D.A.T., REUSS L., ROMANOFF A.L., ROMANOFF A.L., SIMKISS K., SOKAL R.R., STERN C.D., STERN C.D., TAYLOR L.W., TAYLOR L.W., WALSH T.J., ZEUTHEN T.   +27 more
core   +1 more source

Bioinformatic analysis of beta carbonic anhydrase sequences from protozoans and metazoans

Parasites & Vectors, 2014
Background Despite the high prevalence of parasitic infections, and their impact on global health and economy, the number of drugs available to treat them is extremely limited.
Reza Zolfaghari Emameh, Harlan Barker, Martti E E Tolvanen, Csaba Ortutay, Seppo Parkkila   +4 more
doaj   +1 more source

Evolution and diversity of alpha-carbonic anhydrases in the mantle of the Mediterranean mussel (Mytilus galloprovincialis) [PDF]

, 2019
The α-carbonic anhydrases (α-CAs) are a large and ancient group of metazoan-specific enzymes. They generate bicarbonate from metabolic carbon dioxide and through calcium carbonate crystal formation play a key role in the regulation of mineralized ...
Anjos, Liliana, Batista, Frederico, Cardoso, João CR, Ferreira, Vinicius, Félix, Rute, Power, Deborah, Zhang, Xushuai   +6 more
core   +1 more source

Endocervical glandular neoplasia associated with lobular endocervical glandular hyperplasia is HPV-independent and correlates with carbonic anhydrase-IX expression: a Gynaecological Oncology Group Study. [PDF]

, 2013
BackgroundLobular endocervical glandular hyperplasia (LEGH) is a rare lesion of the uterine cervix. It has been proposed that LEGH may represent a precursor lesion to a group of mucinous adenocarcinoma with gastric phenotype (GA) that is independent of ...
Carter, R, Darcy, KM, Hatae, M, Kauderer, J, Liao, SY, Nagao, S, Rodgers, WH, Stanbridge, EJ, Susumu, N, Walker, JL   +9 more
core   +1 more source

Brucella suis carbonic anhydrases and their inhibitors: Towards alternative antibiotics?

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Carbonic anhydrases have started to emerge as new potential antibacterial targets for several pathogens. Two β-carbonic anhydrases, denominated bsCA I and bsCA II, have been isolated and characterized from the bacterial pathogen Brucella suis, the ...
Stephan Köhler, Safia Ouahrani-Bettache, Jean-Yves Winum   +2 more
doaj   +1 more source

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold [PDF]

, 2019
A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1).
Akdemir, A., Amoroso, R., Angeli, A., Carradori, S., Cirilli, R., De Filippis, B., De Monte, C., Guglielmi, P., Maccallini, C., Rotondi, G., Secci, D., Supuran, C. T.   +11 more
core   +2 more sources

Multivalent Carbonic Anhydrases Inhibitors [PDF]

International Journal of Molecular Sciences, 2019
Biomolecular recognition using a multivalent strategy has been successfully applied, this last decade on several biological targets, especially carbohydrate-processing enzymes, proteases, and phosphorylases. This strategy is based on the fact that multivalent interactions of several inhibitory binding units grafted on a presentation platform may ...
Fabrizio Carta, Pascal Dumy, Claudiu T. Supuran, Jean-Yves Winum   +3 more
openaire   +3 more sources

Plant Carbonic Anhydrases, their Role in Stress Defense and Possible Practical Use [PDF]

Journal of Stress Physiology & Biochemistry, 2018
The review presents data on the distribution of carbonic anhydrases in photosynthetic organisms and their location in cellular compartments. The functions of carbonic anhydrases to provide a high photosynthesis rate as well as their participation in ...
Rudenko N.N., Ignatova L.K., Zhurikova E.M., Novichkova N.S., Ivanov B.N.   +4 more
doaj  

Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes

Acta Dermato-Venereologica, 2018
Carbonic anhydrases are ubiquitously expressed enzymes that reversibly hydrate carbon dioxide to bicarbonate and protons. While the main function of carbonic anhydrases is to regulate pH and osmotic balance, their involvement in other physiological ...
Bani Kaur Suri, Navin Kumar Verma, Artur Schmidtchen   +2 more
doaj   +1 more source