Results 61 to 70 of about 27,386 (335)

Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms [PDF]

, 2016
A large number of novel secondary sulfonamides based on the open saccharin scaffold were synthesized and evaluated as selective inhibitors of four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1).
Akdemir, Atilla, Carradori, Simone, Ceruso, Mariangela, D'Ascenzio, Melissa, Florio, Rosalba, Guglielmi, Paolo, Mollica, Adriano, Secci, Daniela, Sobolev, Anatoly P., Supuran, Claudiu T.   +9 more
core   +5 more sources

Role of Histidine‐Containing Peptoids in Accelerating the Kinetics of Calcite Growth

Advanced Functional Materials, EarlyView.
Amphiphilic histidine‐containing peptoids mimic carbonic anhydrase (CA) to accelerate calcite step growth. In the presence of Zn2+, they promote the deprotonation of HCO3−, the desolvation of Ca2+, and the reorganization of interfacial hydration layers, thereby reducing the activation barrier for calcite growth.
Mingyi Zhang, Ying Chen, Chenyang Shi, Progyateg Chakma, James J. De Yoreo, Chun‐Long Chen   +5 more
wiley   +1 more source

Molecular Electrocatalyst Enables Direct Electrochemical Capture and Conversion of CO2 up to Atmospheric Concentration

Angewandte Chemie, EarlyView.
A molecular manganese electrocatalyst enables the direct electrochemical capture and conversion of dilute CO2 (1% – 0.2%) to CO with nearly unit Faradaic efficiency, achieving high efficiency even at atmospheric concentrations (420 ppm). By bypassing energy‐intensive pre‐concentration steps, this integrated approach highlights a sustainable pathway for
Mattia Vettori, Federico Franco, Sergio Fernández, Guillem Pey, Vlad Martin Diaconescu, Josep M. Luis, Julio Lloret‐Fillol   +6 more
wiley   +2 more sources

Carbonic Anhydrases and Their Biotechnological Applications

Biomolecules, 2013
The carbonic anhydrases (CAs) are mostly zinc-containing metalloenzymes which catalyze the reversible hydration/dehydration of carbon dioxide/bicarbonate.
Robert McKenna, Sonika Gill, Christopher D. Boone, Andrew Habibzadegan   +3 more
doaj   +1 more source

The Sodium Channel B4-Subunits are Dysregulated in Temporal Lobe Epilepsy Drug-Resistant Patients [PDF]

, 2020
Temporal lobe epilepsy (TLE) is the most common type of partial epilepsy referred for surgery due to antiepileptic drug (AED) resistance. A common molecular target for many of these drugs is the voltage-gated sodium channel (VGSC).
Falciani, Francesco, Princivalle, Alessandra, Sheilabi, Mariam A., Sims, Edward J., Takeshita, Louise Y.   +4 more
core   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Surface Mutation Thr34His Facilitates Purification of Haemophilus influenza Carbonic Anhydrase via Metal Affinity Chromatography [PDF]

, 2017
In order to pursue Haemophilus influenza carbonic anhydrase (HICA) as a potential drug target, easy and efficient purification methods must be developed. While immobilized metal affinity chromatography (IMAC) may be used, complications with polyhistidine
Cornely, Dr. Kathleen, Foley, Caroline
core   +1 more source

Improving the 'tool box' for robust industrial enzymes. [PDF]

, 2017
This is the final version of the article. Available from Springer Verlag via the DOI in this record.The speed of sequencing of microbial genomes and metagenomes is providing an ever increasing resource for the identification of new robust biocatalysts ...
Littlechild, JA
core   +1 more source

Eutectozymes as Soft Hybrid Materials for Advanced Biocatalysis

Advanced Materials, EarlyView.
Eutectozymes are sustainable hybrid materials that embed a GOx–HRP cascade within hydrophobic eutectogels featuring a dual supramolecular–covalent network. This architecture preserves native enzyme structure and stability, enables efficient heterogeneous biocatalysis in aqueous media, and positions eutectogels as robust platforms for next‐generation ...
Manuel Eduardo Martinez Cartagena, Lucia Suarez, Aitor Ontoria, Francisca J. Benitez, Elixabete Rezabal, María Soledad Orellano, Marcelo Calderón, Cristián Huck‐Iriart, Agustin S. Picco, Matias L. Picchio, Ana Beloqui   +10 more
wiley   +1 more source

Exploring the Pharmacological Potential of Carrageenan Disaccharides as Antitumor Agents: An In Silico Approach

Marine Drugs
Carrageenans have demonstrated enhanced antitumor activity upon depolymerization into disaccharides. However, the pharmacological viability of these disaccharides and their mechanisms of antitumor action remains to be fully elucidated.
Ohana Leticia Tavares Silva, Monique Gabriela das Chagas Faustino Alves, Hugo Alexandre Oliveira Rocha   +2 more
doaj   +1 more source